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排序方式: 共有143条查询结果,搜索用时 15 毫秒
1.
Mio Yamaguchi Kiyoshi Takagi Koki Narita Yasuhiro Miki Yoshiaki Onodera Minoru Miyashita Hironobu Sasano Takashi Suzuki 《International journal of molecular sciences》2021,22(4)
Chemokines secreted from stromal cells have important roles for interactions with carcinoma cells and regulating tumor progression. C-C motif chemokine ligand (CCL) 5 is expressed in various types of stromal cells and associated with tumor progression, interacting with C-C chemokine receptor (CCR) 1, 3 and 5 expressed in tumor cells. However, the expression on CCL5 and its receptors have so far not been well-examined in human breast carcinoma tissues. We therefore immunolocalized CCL5, as well as CCR1, 3 and 5, in 111 human breast carcinoma tissues and correlated them with clinicopathological characteristics. Stromal CCL5 immunoreactivity was significantly correlated with the aggressive phenotype of breast carcinomas. Importantly, this tendency was observed especially in the CCR3-positive group. Furthermore, the risk of recurrence was significantly higher in the patients with breast carcinomas positive for CCL5 and CCR3 but negative for CCR1 and CCR5, as compared with other patients. In summary, the CCL5-CCR3 axis might contribute to a worse prognosis in breast cancer patients, and these findings will contribute to a better understanding of the significance of the CCL5/CCRs axis in breast carcinoma microenvironment. 相似文献
2.
Koki Murano Tomoyoshi Shimobaba Atsushi Sugiyama Naoki Takada Takashi Kakue Minoru Oikawa Tomoyoshi Ito 《Computer Physics Communications》2014
We report fast computation of computer-generated holograms (CGHs) using Xeon Phi coprocessors, which have massively x86-based processors on one chip, recently released by Intel. CGHs can generate arbitrary light wavefronts, and therefore, are promising technology for many applications: for example, three-dimensional displays, diffractive optical elements, and the generation of arbitrary beams. CGHs incur enormous computational cost. In this paper, we describe the implementations of several CGH generating algorithms on the Xeon Phi, and the comparisons in terms of the performance and the ease of programming between the Xeon Phi, a CPU and graphics processing unit (GPU). 相似文献
3.
Unique deterioration with a periodical striped pattern on the injection moldings of polypropylene/rubber blends is reported. After exposure to ultraviolet irradiation with a sunshine fade meter, striped patterns appeared on the injection moldings along the flow direction of the molten resin during the filling process of injection molding, even though the initial specimen showed no sign of any stripe pattern on its surface. The stripe was carefully observed with ultrasonic echo imaging, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. As a result, a number of microvoids were observed inside the injected body at a depth of 50–100 μm from the surface. It became clear that the difference in the number of voids along the flow direction formed the stripe pattern. Surprisingly, these voids occurred in domains comprising a rubber phase. The distribution of voids in depth indicated the existence of a trace of a snakelike flow caused inside the injected body during the injection‐molding process. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007 相似文献
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Back Cover: Tailored Synthesis of 162‐Residue S‐Monoglycosylated GM2‐Activator Protein (GM2AP) Analogues that Allows Facile Access to a Protein Library (ChemBioChem 20/2016) 下载免费PDF全文
6.
Yoshio Oyumi Kiyotaka Inokami Kazuhiro Yamazaki Koki Matsumoto 《Propellants, Explosives, Pyrotechnics》1994,19(4):180-186
Thermal decomposition and the burning properties of BAMO based propellants with HMX or AN/HMX have been investigated. The heat generated by the azide binder decomposition initiated and accelerated the thermal decomposition of HMX and AN. Ammonium perchlorate (AP) and lead stearate with carbon black significantly altered the mechanisms of the thermal decomposition and the burning properties of the HMX based propellants. AP showed an increase in burning rate with a slight decrease in burning rate pressure exponent. The lead catalyst yielded high value of the burning rate with the lowest pressure exponent. The ammonium dichromate also influenced the mechanisms of the thermal decomposition and the burning properties of the AN/HMX samples. The combination of ammonium dichromate and copper chromite was the most effective on the burning rate augmentation of AN/HMX based propellants. AN sublimed and evaporated from the condensed phase and mainly reacted exothermically in the gas phase HMX and AN/HMX based propellants showed smokeless burning characteristics in the small rocket motor combustion tests. 相似文献
7.
Tomoya Hasegawa Mikako Ito Satoru Hasegawa Masaki Teranishi Koki Takeda Shuto Negishi Hiroshi Nishiwaki Jun-ichi Takeda Tyler W. LeBaron Kinji Ohno 《International journal of molecular sciences》2022,23(5)
Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been rarely reported. In addition, the molecular mechanisms underlying the effects of hydrogen remain mostly unelucidated. We found that hydrogen enhances proliferation of four out of seven human cancer cell lines (the responders). The proliferation-promoting effects were not correlated with basal levels of cellular reactive oxygen species. Expression profiling of the seven cells showed that the responders have higher gene expression of mitochondrial electron transport chain (ETC) molecules than the non-responders. In addition, the responders have higher mitochondrial mass, higher mitochondrial superoxide, higher mitochondrial membrane potential, and higher mitochondrial spare respiratory capacity than the non-responders. In the responders, hydrogen provoked mitochondrial unfolded protein response (mtUPR). Suppression of cell proliferation by rotenone, an inhibitor of mitochondrial ETC complex I, was rescued by hydrogen in the responders. Hydrogen triggers mtUPR and induces cell proliferation in cancer cells that have high basal and spare mitochondrial ETC activities. 相似文献
8.
Takashi Soga Akihiro Musa Koki Okabe Kazuhiko Komatsu Ryusuke Egawa Hiroyuki Takizawa Hiroaki Kobayashi Shun Takahashi Daisuke Sasaki Kazuhiro Nakahashi 《Computers & Fluids》2011,45(1):215-221
The building-cube method (BCM) is a new generation algorithm for CFD simulations. The basic idea of BCM is to simplify the algorithm in all stages of flow computation to achieve large-scale simulations. Calculation of a pressure field using the Successive Over Relaxation (SOR) method consumes most of the total execution time required for BCM. In this paper, effective implementations on modern vector and scalar processors are investigated. NEC SX-9 and Intel Nehalem-EX are the latest vector and scalar processors. Those processors have much higher peak performances than their previous-generation processors. However, their memory bandwidth improvement cannot catch up with the performance improvement of processors. This is the so-called memory wall problem. In our paper, we discuss optimization techniques for implementation of the SOR method based on architectural characteristics of these modern processors, and evaluate their effects on the sustained performances of these processors for BCM. 相似文献
9.
Sharmy Saimon Mano Koki Kanehira Akiyoshi Taniguchi 《International journal of molecular sciences》2013,14(7):13154-13170
The innate immune response is the earliest cellular response to infectious agents and mediates the interactions between microbes and cells. Toll-like receptors (TLRs) play an important role in these interactions. We have already shown that TLRs are involved with the uptake of titanium dioxide nanoparticles (TiO2 NPs) and promote inflammatory responses. In this paper, we compared role of cellular uptake and inflammatory response via TLR 4 to lipopolysaccharide (LPS) and TiO2 NPs. In the case of LPS, LPS binds to LPS binding protein (LBP) and CD 14, and then this complex binds to TLR 4. In the case of TiO2 NPs, the necessity of LBP and CD 14 to induce the inflammatory response and for uptake by cells was investigated using over-expression, antibody blocking, and siRNA knockdown experiments. Our results suggested that for cellular uptake of TiO2 NPs, TLR 4 did not form a complex with LBP and CD 14. In the TiO2 NP-mediated inflammatory response, TLR 4 acted as the signaling receptor without protein complex of LPS, LBP and CD 14. The results suggested that character of TiO2 NPs might be similar to the complex of LPS, LBP and CD 14. These results are important for development of safer nanomaterials. 相似文献
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