辣椒疫病菌对氟吗啉的抗药性研究

为了评估氟吗啉的未来抗性风险，以辣椒疫病菌为靶标，通过室内抗性菌株的驯化、筛选，以及紫外线诱变等方法，初步探索了辣椒疫病菌对氟吗啉的抗性情况。结果表明：抗性菌株对氟吗啉的抗性倍数较低，在3.45～11．33，生长速率明显低于野生敏感菌株。由此可见辣椒疫病菌对氟吗啉的抗性风险可能较低。     

基于组件的虚拟实验室反馈模型

提出了一种基于组件的虚拟实验室反馈模型. 该模型针对虚拟实验室中的实验设备以组件形式实现的特点, 把实验流程的拓扑结构以及实验设备的参数转换为有特定含义的字符串, 同时建立一个实验参照库, 库中预存好标准实验流程字符串, 用户实际搭建的实验流程字符串与库中的预存字符串进行模式匹配, 从而根据匹配结果给出实验指导意见. 该模型满足了学习者在虚拟实验过程对于纠错指导和效果评价的需求, 为改善学习者的使用体验提供了一种解决思路.     

Application of system dynamics in analyzing the carrying capacity of water resources in Yiwu City,China

A risk assessment model for water shortage is constructed using a risk analysis method based on the information diffusion theory. The application of this model is demonstrated in the city of Yiwu in Zhejiang Province, China. Based on the analytical results from a small sample, this study indicates that the present model is more stable and effective than the traditional model. Risk assessment results are used to analyze the carrying capacity of water resources from an ecological angle. For this study, the carrying capacity of water resources is defined as the maximum volume of water suitable for supporting human activity in certain stages of social development that can be borne by water resources under favorable ecological conditions. Further study on Yiwu is also performed, with results indicating that water shortages in this city are not related to types of water source, but can be classified in terms of water quality and conservation. To verify the results of theoretical investigation in this paper, the authors simulate changes in the carrying capacity of water resources under the conditions of future water management policies. This simulation uses the system dynamics (SD) model, based on the historical data collected by the city over the past 20 years and governmental plans to raise inhabitants’ living standards between the present and 2020. The paper simultaneously indicates that both singularly pursuing fast economic development at the expense of the environment and promoting environmental protection via reduced economic development are undesirable for Yiwu. Simultaneously giving consideration to both the economic development and environmental protection is likely to produce better overall results. However, if the present water supply level is maintained but does not increase in the near future, Yiwu's water supply will be unable to satisfy requirements even under this scheme. In this case, the carrying capacity of water resources in the region can only be effectively improved by promoting more efficient use of water and water conservation schemes, as well as strengthening long-term investment in environmental protection.     

传感器网络中基于源节点有限洪泛的源位置隐私保护协议

无线传感器网络广泛应用于目标监测,攻击者能够通过逆向、逐跳追踪数据包的方式定位数据源节点,因此,需要对数据源节点的位置隐私进行保护.已有的源位置隐私保护协议产生的幻像源节点集中在真实的源节点附近,不能够较好地保护真实源节点的位置隐私.为此,文中提出基于源节点有限洪泛的源位置隐私保护协议PUSBRF.考虑到具有更强视觉能力的攻击者,文中进一步提出EPUSBRF协议.实验表明,与已有的源位置隐私保护协议相比,文中提出的两种协议显著提高了源位置隐私的安全性,平均安全时间提高将近一倍.     

基于DRAM和PCM的混合主存模拟器

相变存储器（PCM）由于其非易失性、高读取速度以及低静态功耗等优点,已成为主存研究领域的热点.然而,目前缺乏可用的PCM设备,这使得基于PCM的算法研究得不到有效验证.因此,本文提出了利用主存模拟器仿真并验证PCM算法的思路.本文首先介绍了现有主存模拟器的特点,并指出其并不能完全满足当前主存研究的实际需求,在此基础上提出并构建了一个基于DRAM和PCM的混合主存模拟器.与现有模拟器的实验比较结果表明,本文设计的混合主存模拟器能够有效地模拟DRAM和PCM混合存储架构,并能够支持不同形式的混合主存系统模拟,具有高可配置性.最后,论文通过一个使用示例说明了混合主存模拟器编程接口的易用性.     

物理场处理对葵花油脂肪酸组成影响的研究

主要讨论了超声场和微波场处理对葵花油脂肪酸的影响,并用气-质联用色谱分别检测了未经处理的和经物理场处理的葵花油的脂肪酸组成和相对含量.结果表明,超声波和微波处理对葵花油的脂肪酸组成和相对含量有一定影响,但影响不显著.     

Bio-information scanning technology using an optical pick-up head

We have developed a low cost and a highly compact bio-chip detection technology by modifying a commercially available optical pick-up head for CD/DVD. The highly parallel and miniaturized hybridization assays are addressed by the fluorescence emitted by the DNA-chip using the optical pick-up head. The gap between the objective lens and the bio-chip is regulated by the focus servo during the detection of the fluorescence signal. High-resolution and high-speed scanning is effectively realized by this simple scanning system instead of utilizing high-precision mechanism. Regardless of achievement of effective detection mechanism, the technique of fluorescence detection can prove to be disadvantageous because of the low stability of the dyes with low S/N ratio and an expensive setup such as a PMT detector is always required for fluorescence detection. We propose, for the first time, a novel scanning scheme based on metal nanoparticles in combination with a bio-chip substrate having a phase change recording layer. We found that the phase change process is highly affected by the existence of the densely condensed metal nanoparticles on the phase change layer during the writing process of the pick-up head.     

一种基于合作博弈的均衡路由方法

网络资源公平性分配是网络可存性研究中的关键问题,路由选择算法是影响网络资源分配的公平性和均衡性的关键因素。本文研究路由器路径选择中的均衡性问题,提出了基于博弈论思想的解决方案,即将IPv6协议中的任意播路由问题看作是合作参与者间的博弈;针对该博弈问题,建立了路由算法的合作博弈模型,求得了该博弈均衡点,并在此基础上,提出了一种基于合作博弈的均衡路由方法;最后通过实验仿真了算法结果。     

基于显著封闭边界的图像检索算法

在分析了基于边缘的图像检索方法的缺点后,提出了一种基于显著封闭边界的图像检索新算法。它使用基于图论方法的边缘比算法从噪声图像中获取图像的显著封闭边界,然后以显著封闭边界来代表图像,每条显著封闭边界由两个特征：边缘幅度直方图和边缘角度直方图来刻画,并综合这两个特征进行图像间的相似性度量。实验结果表明,本文算法具有较高的检索准确率。     

The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. Here we showed that miR-433 and miR-127 were significantly down-regulated in gastric cancer (GC) tissues compared with the adjacent normal regions in 86 paired samples. Moreover, the lower level of miR-433 and miR-127 was associated with pM or pTNM stage in clinical gastric cancer patients. The restored expression of miR-433 and miR-127 in GC cells upon 5-Aza-CdR and TSA treatment suggested the loss of miR-433 and miR-127 was at least partly regulated by epigenetic modification in GC. Furthermore, the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines HGC-27 inhibits cell proliferation, cell cycle progression, cell migration and invasion by directly interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.