全文获取类型
收费全文 | 2423篇 |
免费 | 111篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 15篇 |
综合类 | 4篇 |
化学工业 | 515篇 |
金属工艺 | 18篇 |
机械仪表 | 21篇 |
建筑科学 | 107篇 |
矿业工程 | 3篇 |
能源动力 | 35篇 |
轻工业 | 348篇 |
水利工程 | 34篇 |
石油天然气 | 1篇 |
无线电 | 83篇 |
一般工业技术 | 323篇 |
冶金工业 | 844篇 |
原子能技术 | 4篇 |
自动化技术 | 181篇 |
出版年
2024年 | 4篇 |
2023年 | 35篇 |
2022年 | 87篇 |
2021年 | 90篇 |
2020年 | 57篇 |
2019年 | 47篇 |
2018年 | 63篇 |
2017年 | 50篇 |
2016年 | 57篇 |
2015年 | 45篇 |
2014年 | 63篇 |
2013年 | 117篇 |
2012年 | 111篇 |
2011年 | 162篇 |
2010年 | 128篇 |
2009年 | 129篇 |
2008年 | 154篇 |
2007年 | 126篇 |
2006年 | 107篇 |
2005年 | 95篇 |
2004年 | 85篇 |
2003年 | 69篇 |
2002年 | 76篇 |
2001年 | 42篇 |
2000年 | 52篇 |
1999年 | 44篇 |
1998年 | 39篇 |
1997年 | 48篇 |
1996年 | 42篇 |
1995年 | 45篇 |
1994年 | 55篇 |
1993年 | 36篇 |
1992年 | 32篇 |
1991年 | 9篇 |
1990年 | 25篇 |
1989年 | 16篇 |
1988年 | 25篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1970年 | 1篇 |
1968年 | 2篇 |
排序方式: 共有2536条查询结果,搜索用时 12 毫秒
1.
Dr. Maria L. Di Paolo Dr. Michael S. Christodoulou Dr. Alessandra M. Calogero Dr. Luca Pinzi Prof. Giulio Rastelli Prof. Daniele Passarella Prof. Graziella Cappelletti Prof. Lisa Dalla Via 《ChemMedChem》2019,14(18):1641-1652
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity. 相似文献
2.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
3.
4.
5.
The ability to accurately and reliably predict whether an older adult will commit suicide has eluded clinicians and researchers. A random national sample of psychologists who work with older adults was surveyed regarding their perception of 36 risk factors for completed suicide and indirect self-destructive behavior in older adults. This study produced a profile of psychologists' assessment and treatment practices when working with suicidal older adults. Determining what psychologists consider to be the most salient risk factors for completed suicide is important in identifying a minimum standard that clinicians should follow when assessing older adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Mazzocco Michèle M. M.; Freund Lisa S.; Baumgardner Thomas L.; Forman Lisa; Reiss Allan L. 《Canadian Metallurgical Quarterly》1995,9(4):470
An extensive evaluation was conducted with 16-yr-old monozygotic twins concordant for the fragile X full mutation but discordant for mental retardation. The clearly affected twin had an IQ score of 47; 77% of her neuropsychological z scores were at least 2 SDs below average. Her sister had an IQ score of 105 and average neuropsychological performance. However, each girl demonstrated relative verbal strengths and visual-spatial weaknesses. Their parents rated each girl as having significant problems with attention, conduct, anxiety-withdrawal, and hyperactivity. The girls did not rate themselves as having significant anxiety. These findings are consistent with group data on females with fragile X and demonstrate the wide range of effects associated with the fragile X full mutation. This case report implicates the importance of a psychosocial phenotype of fragile X independent of cognitive ability level. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
Four experiments examined 10-mo-old infants' causal event perception. Exp 1 replicated previous studies except that the specific objects used as agent and recipient varied from trial to trial. Under these conditions infants did not process the causality. Instead they keyed on specific temporal and spatial differences among the events. Exp 2 showed that infants notice a change in the particular agent performing either a causal or noncausal action. Exp 3 showed that infants do not notice a change in the type of action done to a particular recipient. Exp 4 demonstrated that infants do not pay attention to the object used as a recipient. As a whole, the results indicate that 10-mo-old infants perceive the causality of simple events by associating a specific agent with the causal action. These results provide more support for an information-processing view than for the view that infants have a causal module. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
John D. Fitzsimons Bill Williston Georgina Williston Lisa Brown Abdel El-Shaarawi Lenore Vandenbyllaardt Dale Honeyfeld Don Tillitt Martha Wolgamood Scott B. Brown 《Journal of Great Lakes research》2007,33(1):93-103
Alewives (Alosa pseudoharengus), the major prey fish for Lake Ontario, contain thiaminase. They are associated with development of a thiamine deficiency in salmonines which greatly increases the potential for developing an early mortality syndrome (EMS). To assess the possible effects of thiamine deficiency on salmonine reproduction we measured egg thiamine concentrations for five species of Lake Ontario salmonines. From this we estimated the proportion of families susceptible to EMS based on whether they were below the ED20, the egg thiamine concentration associated with 20% mortality due to EMS. The ED20s were 1.52, 2.63, and 2.99 nmol/g egg for Chinook salmon (Oncorhynchus tshawytscha), lake trout (Salvelinus namaycush), and coho salmon (Oncorhynchus kisutch), respectively. Based on the proportion of fish having egg thiamine concentrations falling below the ED20, the risk of developing EMS in Lake Ontario was highest for lake trout, followed by coho (O. kisutch), and Chinook salmon, with the least risk for rainbow trout (O. mykiss). For lake trout from western Lake Ontario, mean egg thiamine concentration showed significant annual variability during 1994 to 2003, when the proportion of lake trout at risk of developing EMS based on ED20 ranged between 77 and 100%. Variation in the annual mean egg thiamine concentration for western Lake Ontario lake trout was positively related (p < 0.001, r2 = 0.94) with indices of annual adult alewife biomass. While suggesting the possible involvement of density-dependent changes in alewives, the changes are small relative to egg thiamine concentrations when alewife are not part of the diet and are of insufficient magnitude to allow for natural reproduction by lake trout. 相似文献
9.
Lisa J. Fauci 《Computers & Fluids》1992,21(4):583-598
We simulate solid particle transport by peristalsis in a two-dimensional channel with sinusoidal waves. The fluid is regarded as viscous and incompressible, and the walls of the channel and the particle as neutrally buoyant elastic boundaries immersed in this fluid. Using the immersed boundary technique, we are able to computationally model fluid-particle interaction. To demonstrate the validity of our computational approach, we first present results of computations without solid particles and compare them with existing theory and computations. We then examine how the transport of the solid particle depends upon its diameter, the Reynolds number and its initial placement in the channel. We also present evidence that the mean transport speed of a particle increases geometrically as its diameter approaches the channel width. 相似文献
10.