TiO2/MXene-Assisted LDI-MS for Urine Metabolic Profiling in Urinary Disease

Cancer remains an intractable medical problem. Rapid diagnosis and identification of cancer are critical to differentiate it from nonmalignant diseases. High-throughput biofluid metabolic analysis has potential for cancer diagnosis. Nevertheless, the present metabolite analysis method does not meet the demand for high-throughput screening of diseases. Herein, a high-throughput, cost-effective, and noninvasive urine metabolic profiling method based on TiO₂/MXene-assisted laser desorption/ionization mass spectrometry (LDI-MS) is presented for the efficient screening of bladder cancer (BC) and nonmalignant urinary disease. Combined with machine learning, TiO₂/MXene-assisted LDI-MS enables high diagnostic accuracy (96.8%) for the classification of patient groups (including 47 BC and 46 ureteral calculus (UC) patients) from healthy controls (113 cases). In addition, BC patients can also be identified from noncancerous UC individuals with an accuracy of 88.3% in the independent test cohort. Furthermore, metabolite variations between BC and UC individuals are investigated based on relative quantification, and related pathways are also discussed. These results suggest that this method, based on urine metabolic patterns, provides a potential tool for rapidly distinguishing urinary diseases and it may pave the way for precision medicine.     

加入WTO后对中国会计业的影响

中国政府已于2001年12月正式加入做为当代世界规范和经济贸易关系最具权威的国际性组织WTO.加入WTO,对中国来说既是机遇,同时又是挑战,它的影响是全面的、全方位的.而对于中国会计业的影响也是深刻的,中国经济、中国企业要走向世界,中国的会计业也必须直面世界,按国际惯例行事,因此,深刻研究和分析加入WTO后对中国会计业的冲击、挑战以制定相应的政策、方针、准则就显得非常的迫切.     

Application of Direct Ignition Technology with Minimum Gasified Oil in Lignite-Fired Boiler

The firing is in the stable condition and the rate of oil saving comes up to 64%, after Fularji Power Plant adopted the technology of minimum gasified oil igniting pulverized lignite directly and the technology of multistage coal combustion with energy amplified stage by stage.     

3D FDTD Implementation for Scattering of Electric Anisotropic Dispersive Medium Using Recursive Convolution Method

The finite-difference time-domain method based on recursive convoltion method (RC-FDTD) for the electric anisotropic dispersive medium is discussed in detail. To exemplify the availability of the three-dimensional RC-FDTD algorithm, the backscattering Radar-Cross-Section(RCS) of a non-magnetized plasma sphere is computed, and the numerical results are the same as the one of the Shift Operater-FDTD method, and show that the RC-FDTD method is correct and efficient. In addition, the co-polarized and cross-polarized backscattering time-domain of a magnetized plasma sphere are obtained by the RC-FDTD algorithm. The results show that when the external magnetic field is implemented, the cross-polarized component appear, evidently.     

城市化进程中的小城镇交通初探

通过对小城镇城市结构、路网结构、交通结构和交通管理特征进行详细分析，得出小城镇交通问题症结所在，并初步提出小城镇交通规划和交通治理的对策。     

Evaluation of Morphology—Stable Critical Size of KNbO3 Crystals

Skeletal form of KnbO3 crystals growing in Li2B4O7 solvent was in-situ observed at 900℃ and it was found that shallow depression started to develop on the surface of KnbO3 crystals when the crystal size exceeded several micron,typically 7 micron.Based on the quantitative criterion derived by Chernov,the estimated critical size of KNbO3 crystals was 1 micron,which was consistent with the experimental measurement.The kinetic coefficients,Kcorner and Kcr,in the criterion were experimentally obtained in the diffusive-convective and diffusive-advective flow states respectively.     

对氧化物熔体浮区中重力对流的数值模拟

利用有限元分析方法数值模拟了界面形状对氧化物高温熔体碟形浮区中的温度分布和重力对流速率的影响，发现界面形状对重力对流速率有较大的影响，对于凸面，相对于炉圈平面5％的偏离使重力对流速率增大25％，偏离越大，重力对流速度越大，对于凹面，5％的偏离使重力对流速率减小15．7％，偏离越大，重力对流速度越小。     

装载机多路阀操纵系统改进设计

论述了装载机现行的操纵机构,分析了液压先导操纵阀的应用局限性。介绍了气动助力器的工作原理,通过对操纵杆上的期望力分析计算获得满足性能要求的操纵力。装载机操纵机构借助助力器的助力作用,可以用较小的操纵力对装载机进行轻松操纵,从而使操作轻便灵活。     

异型材挤出口模内的流动模拟

本文根据挤出机理，对口模内的流动行为进行适当的简化和假定，建立了挤出口模内流动分析的数学模型，并采用横截面／假想区域法实现了复杂异型材挤出口模内的数值模拟，数值分析结果与三维有限元解和解析解的对比，取得了满意的效果。     

三维立体成像及其应用

本文首先介绍了三种传统的主要三维立体成像方法，即透镜板三维成像方法，投影式三维显示和全息照相术，其次，重点对于采用计算机产生的三维立体景象的方法进行了综述，其中包括人们近年来研究较多的自动立体成像技术等，最后给出了三维立体成像技术在航空航天，工业，教育，医学，军事等领域的应用实例，并预测了三维立体成像技术今后的主要发展方向。