不同围压和层理下板岩三轴蠕变试验及损伤模型研究

为了研究围压和层理对板岩三轴蠕变特性的影响,制备了最大主应力方向与层理夹角为 0°和 90°的 2 组岩样( 0°为平行组; 90°为垂直组) ,分别进行 5 MPa、10 MPa、15 MPa 围压下的三轴蠕变试验。结果显示: 板岩在三轴应力条件下的蠕变具有瞬时弹性阶段、稳定蠕变阶段、加速蠕变阶段这三个阶段特征; 在同一围压下,垂直组试样加载级数大于平行组岩样加载级数; 垂直组试样的瞬时弹性应变高于平行组试样; 垂直组试样的累计蠕变应变均低于平行组试样。计算长期强度与峰值强度的比值得到垂直组试样的强度损伤低于平行组试样; 围压越高,试样蠕变变形越小,峰值强度和长期强度越高。基于 Kachanov 蠕变损伤理论,考虑层理角度的损伤,引进一个弹塑性损伤元件,建立了描述不同层理角度板岩蠕变过程的改进西原模型,用该模型对试验数据进行拟合,结果表明: 模型能够较好地反映蠕变三阶段; 垂直组试样的弹性模量、黏滞系数比平行组试样相对较大,蠕变参数基本随着围压的增大而增大,体现了围压效应,这与试验结果相吻合。     

The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype

Nicotine exposure either from maternal cigarette smoking or e-cigarette vaping is one of the most common risk factors for neurodevelopmental disease in offspring. Previous studies revealed that perinatal nicotine exposure programs a sensitive phenotype to neonatal hypoxic-ischemic encephalopathy (HIE) in postnatal life, yet the underlying mechanisms remain undetermined. The goal of the present study was to determine the regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps. All experiments were conducted in offspring pups at postnatal day 9 (P9). Perinatal nicotine exposure significantly enhanced expression of miR-181a but attenuated autophagy-related protein 5 (ATG5) mRNA and protein levels in neonatal brains. Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. Locked nucleic acid (LNA)-miR-181a antisense reversed perinatal nicotine-mediated increase in H/I-induced brain injury and normalized aberrant ATG5 expression. In addition, nicotine exposure attenuated a long non-coding RNA (lncRNA) H19 expression level. Knockdown of H19 via siRNA increased the miR-181a level and enhanced H/I-induced neonatal brain injury. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring.     

供电企业需求侧管理的探讨

从电力需求侧管理基础知识的认知开始,分享了国内外需求侧管理的经验和启示,思考并分析了当前实施电力需求侧管理中存在的障碍,最后为完善供电企业需求侧管理提出了建议。     

常用低压变频电机风冷系统的几点思考

结合工程实例,就常用低压变频电机冷却风机的配电、控制等展开分析和探讨,研究不同使用条件下低压变频电机冷却风机宜采用的控制方案.     

Synthesis and characterization of sulfonated block copolyimides derived from 4,4'‐sulfide‐bis(naphthalic anhydride) for proton exchange membranes

A series of sulfonated copolyimides (SPIs) with hydrophilic segment length of 20–60 based on 4,4′‐sulfide‐bis(naphthalic anhydride) (SBNA) have been successfully synthesized to improve hydrolytic stability and proton conductivity. The SPI membranes were cast from their m‐cresol solutions, and they were characterized by determining the water uptake, water swelling ratio, mechanical properties, hydrolytic stability, oxidative stability, and proton conductivity. It was found that the water uptake of SPI membranes was low and decreased as the hydrophilic segment length increased, which led to good dimensional stability. In addition, the SPI membranes with low ion‐exchange capacity (IEC) value displayed excellent hydrolytic stability and retained good mechanical properties even after harsh hydrolysis testing, in which the block SPI with hydrophilic segment length of 40 had the best hydrolytic stability, while those with high IEC value showed an apparent decrease. All of the block SPI membranes show better conductivity than the random ones at the temperature range from 30 to 70°C. Interestingly, the proton conductivities of random SPI membranes were higher than that of corresponding block ones at 90°C. The block SPI with hydrophilic segment length of 40 gave the highest proton conductivity as the temperature increased among the block SPIs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41501.     

Introductory paper

This special section is devoted to a selection of contributions originally presented at the 1st International Workshop on Parallel and Distributed Model Checking (PDMC 2002), which took place in Brno, Czech Republic in September 2002 as a satellite event of the 13th conference on concurrency theory (CONCUR 2002). The growing importance of automated formal verification in industry is driving a growing interest in those aspects that have a direct impact on its applicability to real-world problems. One of the main technical challenges is in devising tools that allow one to handle large state spaces. In the last several years numerous approaches to solving this problem have been developed. Recently there has been increasing interest in parallelizing and distributing verification techniques. Papers that appear in this special section provide an interesting sampling of typical approaches in this direction.     

胶州市水利风景区建设与管理模式探索

胶州市立足科学发展观,坚持人水和谐,综合规划,建设了水库特色景区、历史人文河道景区和多功能品牌少海景区等水利风景区;在管理上探索了公益化与群众共享、管理物业化与市场运作相结合的多样管理 模式.目前,胶州市水利风景区已产生巨大的经济、社会和生态效益.     

山洲水库生态清洁型小流域建设探讨

山洲水库担负着向胶州市城区供水的重要职责,为适应经济社会发展的新形势,保护饮用水源的清洁,在水土保持工作中,大力推进集生态修复、生态治理、生态保护为一体的生态清洁型小流域建设.     

Mathematical Modeling of Encapsulated Buffer Performance in Sand Columns

A one-dimensional mathematical model was developed to simulate pH control using an encapsulated phosphate buffer during denitrification in a sand column. The parameters required for the model were obtained from direct physical measurement, from a tracer study to characterize the dispersion coefficient in the column, and from batch experiments designed to obtain an empirical expression describing the variation of the first-order rate constant for the encapsulated buffer core release with pH. First-order kinetic constants describing the rates of denitrification and ethanol biodegradation were obtained by fitting the model to column runs without the encapsulated buffer. With these parameters, the model was subsequently used to predict the performance of column runs containing the encapsulated buffer. Since denitrification was essentially complete in the sand columns, an increase in the effluent pH was observed. This pH increase was counteracted by the controlled release of the acidic core of the encapsulated buffers added in the columns. The model reasonably predicted the release of the encapsulated buffer core and the performance of the encapsulated buffer for controlling pH in the column.