Fluid, solid and fluid-structure interaction simulations on patient-based abdominal aortic aneurysm models

This article describes the use of fluid, solid and fluid-structure interaction simulations on three patient-based abdominal aortic aneurysm geometries. All simulations were carried out using OpenFOAM, which uses the finite volume method to solve both fluid and solid equations. Initially a fluid-only simulation was carried out on a single patient-based geometry and results from this simulation were compared with experimental results. There was good qualitative and quantitative agreement between the experimental and numerical results, suggesting that OpenFOAM is capable of predicting the main features of unsteady flow through a complex patient-based abdominal aortic aneurysm geometry. The intraluminal thrombus and arterial wall were then included, and solid stress and fluid-structure interaction simulations were performed on this, and two other patient-based abdominal aortic aneurysm geometries. It was found that the solid stress simulations resulted in an under-estimation of the maximum stress by up to 5.9% when compared with the fluid-structure interaction simulations. In the fluid-structure interaction simulations, flow induced pressure within the aneurysm was found to be up to 4.8% higher than the value of peak systolic pressure imposed in the solid stress simulations, which is likely to be the cause of the variation in the stress results. In comparing the results from the initial fluid-only simulation with results from the fluid-structure interaction simulation on the same patient, it was found that wall shear stress values varied by up to 35% between the two simulation methods. It was concluded that solid stress simulations are adequate to predict the maximum stress in an aneurysm wall, while fluid-structure interaction simulations should be performed if accurate prediction of the fluid wall shear stress is necessary. Therefore, the decision to perform fluid-structure interaction simulations should be based on the particular variables of interest in a given study.     

An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm

The relationship between hemodynamics and thrombus deposition in abdominal aortic aneurysm is investigated for three patients (A, B and C), each with mature fusiform aneurysms. Our methodology utilises initial and follow-up computerised tomography scans for each patient to identify regions of mural thrombus growth and to provide patient-specific models for hemodynamic analysis using computational fluid dynamics. The intervals between scans for patients A, B and C were 17, 15 and 3 months, respectively. The simulations were performed using physiologically realistic boundary conditions. The hemodynamic features of the flow considered include the velocity field, the shear strain rate field, the time averaged wall shear stress and the oscillatory shear index. The parameter that showed best correlation with the location of thrombus growth was the oscillatory shear index. In particular, in the case of patient C where the interval between scans was the shortest, thrombus growth was observed at regions of low oscillatory shear index (OSI < 0.1).     

The effect of high hydrostatic pressure on the microbiological quality and safety of carrot juice during refrigerated storage

The microbial quality of untreated and pressure-treated carrot juice was compared during storage at 4, 8 and 12 °C. High pressure treatment at 500 MPa and 600 MPa (1 min/20 °C) reduced the total counts by approximately 4 log CFU ml⁻¹ and there was very little growth of the survivors during storage at 4 °C for up to 22 days. Total counts increased during storage of pressure-treated juice at 8 °C and 12 °C but took significantly longer to reach maximum levels compared to the untreated juice. The microflora in the untreated juice consisted predominantly of Gram-negative bacteria, identified as mostly Pantoea spp., Erwinia spp. and Pseudomonas spp. Initially the pressure-treated juice contained low numbers of spore-forming bacteria (Bacillus spp. and Paenibacillus spp.) and Gram-positive cocci; the spore-formers continued to dominate during storage.     

Toward a benchmarking framework for research into bio-inspired hardware-software artefacts

In this paper, we suggest that one of the more crucial tasks currently facing researchers into the field of autonomous mobile robotics is the provision of a common task, or set of tasks, as a means of evaluating different approaches to robot design and architecture, and the generation of a common set of experimental frameworks to facilitate these different approaches. This paper stars with a brief introduction to the field, and behavior-based control in particular. We then discuss the issue of animal versus robot behavior, and focus on simulated experimentation versus embodied robotics. Finally, we move to the feasibility of evaluating and benchmarking different architectures, with the aim of producing mobile robots of continuously higher utility, with specific reference to our current four-layered robot control architecture. This work was presented in part at the Fifth International Symposium on Artificial Life and Robotics, Oita, Japan, January 26–28, 2000     

Evolutionary control of bipedal locomotion in a high degree-of-freedom humanoid robot: first steps

This article describes a methodology, together with an associated series of experiments employing this methodology, for the evolution of walking behavior in a simulated humanoid robot with up to 20 degrees of freedom. The robots evolved in this study learn to walk smoothly in an upright or near-upright position and demonstrate a variety of different locomotive behaviors, including “skating,” “limping,” and walking in a manner curiously reminiscent of a mildly or heavily intoxicated person. A previous study demonstrated the possible potential utility of this approach while evolving controllers based on simulated humanoid robots with a restricted range of movements. Although walking behaviors were developed, these were slow and relied on the robot walking in an excessively stooped position, similar to the gait of an infirm elderly person. This article extends the previous work to a robot with many degrees of freedom, up to 20 in total (arms, elbows, legs, hips, knees, etc.), and demonstrates the automatic evolution of fully upright bipedal locomotion in a humanoid robot using an accurate physics simulator. This work was presented in part at the 11th International Symposium on Artificial Life and Robotics, Oita, Japan, January 23–25, 2006     

Link Travel Times II: Properties Derived from Traffic-Flow Models

We investigate the properties of travel times when the latter are derived from traffic-flow models. In particular we consider exit-flow models, which have been used to model time-varying flows on road networks, in dynamic traffic assignment (DTA). But we here define the class more widely to include, for example, models based on finite difference approximations to the LWR (Lighthill, Whitham and Richards) model of traffic flow, and large step versions of these. For the derived travel times we investigate the properties of existence, uniqueness, continuity, first-in-first-out (FIFO), causality and time-flow consistency (or intertemporal consistency). We assume a single traffic type and assume that time may be treated as continuous or as discrete, and for each case we obtain conditions under which the above properties are satisfied, and interrelations among the properties. For example, we find that FIFO is easily satisfied, but not strict causality, and find that if we redefine travel time to ensure strict causality then we lose time-flow consistency, and that neither of these conditions is strictly necessary or sufficient for FIFO. All of the models can be viewed as an approximation to a model that is continuous in time and space (the LWR model), and it seems that any loss of desirable properties is the price we pay for using such approximations. We also extend the exit-flow models and results to allow inhomogeneity over time (link capacity or other parameters changing over time), and show that FIFO is still ensured if the exit-flow function is defined appropriately.     

A Model-View-Controller (MVC) architecture for contextual visualisation of task-based multi-dimensional energy KPIs in a manufacturing process

Existing energy-monitoring tools do not offer to monitor the basic 3 C’s of energy, that is, cost, carbon emission and more importantly direct energy consumption with its associated value-added and auxiliary components in a single envelope during the entire hierarchy of a manufacturing process. The visualisation of these hierarchical Key process indicators (KPIs), however, poses a multi-dimensional and hierarchal data visualisation problem. We in this paper introduce through Focus-plus-Context and treemap visualisation techniques, a platform-independent pervasive software solution, providing task-based contextual visualisation of hierarchical, multi-dimensional and relevant energy KPIs such as Total Production Units with total production energy consumed, Energy Intensity, Energy cost per production unit and Carbon emission through the entire manufacturing hierarchy of a product drilling down from the factory level to specific production lines, machines or processes. A comparison of existing energy management software along with multi-dimensional visualisation techniques is also presented in this paper.     

Novel thin-walled nerve conduit with microgrooved surface patterns for enhanced peripheral nerve repair

Randomly aligned nerve cells in vitro on conventional culture substrata do not represent the complex neuronal network in vivo and neurites growing in uncontrolled manner may form neuroma. It is of great importance to mimic the organised growth pattern of nerve cells in the study of peripheral nerve repair. The aim of this work was to modify and optimize the photolithographic technique in creating a reusable template in the form of a silicon wafer that could be used to produce contact guidance on biodegradable polymer surface for the orientated growth of nerve cells. Micro-grooves (approximately 3 μm in depth) were etched into the silicon template using KOH at increased temperature. The originality of this work lies in the low cost and high efficiency method in producing microgrooves on the surface of biodegradable ultra-thin polymer substrates (50–100 μm), which can be readily rolled up to form clinically implantable nerve conduits. The design of a pattern with small ridge width (i.e., 5 μm) and bigger groove width (i.e., 20 μm) favored the alignment of cells along the grooves rather than on the ridges of the patterns, which minimized the effect of cross growing of neurites between adjacent grooves. Effectively, enhanced nerve regeneration could be anticipated from these patterned conduits.     

Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation

Engineering native‐like myocardial muscle, recapitulating its fibrillar organization and mechanical behavior is still a challenge. This study reports the rational design and fabrication of ultrastretchable microfiber scaffolds with controlled hexagonal microstructures via melt electrowriting (MEW). The resulting structures exhibit large biaxial deformations, up to 40% strain, and an unprecedented compliance, delivering up to 40 times more elastic energy than rudimentary MEW fiber scaffolds. Importantly, when human induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CM) are encapsulated in a collagen‐based hydrogel and seeded on these microstructured and mechanically tailored fiber scaffolds, they show an increase in beating rate (1.5‐fold), enhanced cell alignment, sarcomere content and organization as well as an increase in cardiac maturation‐related marker expression (Cx43 1.8‐fold, cardiac Actin 1.5‐fold, SERCA2a 2.5‐fold, KCNJ2 1.5‐fold, and PPARGC1a 3.6‐fold), indicative of enhanced iPSC‐CM maturation, as compared to rudimentary fiber scaffolds. By combining these novel fiber scaffolds with clinically relevant human iPSC‐CMs, a heart patch that allows further maturation of contractile myocytes for cardiac tissue engineering is generated. Moreover, the designed scaffold allows successful shape recovery after epicardial delivery on a beating porcine heart, without negative effects on the engineered construct and iPSC‐CM viability.