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1.
Marcella Bonchio Mauro Carraro Martino Gardan Gianfranco Scorrano Enrico Drioli Enrica Fontananova 《Topics in Catalysis》2006,40(1-4):133-140
The incorporation of decatungstate in polymeric membranes provides new heterogeneous photocatalysts for the oxidation of organic
substrates under oxygen atmosphere at 25 °C. Photocatalytic membranes have been prepared yielding polymeric films with a high
thermal, chemical and mechanical stability (PVDF, PDMS, Hyflon). Surface spectroscopy techniques including transmittance and
reflectance UV-Vis and FT-IR have been used to assess the photocatalyst integrity within the polymeric support. Catalyst screening
has been performed under both homogeneous and heterogeneous photooxygenation conditions. The photocatalyst activity has been
evaluated in terms of the substrate conversion, turnover numbers, and recycling experiments. A membrane induced selectivity
behavior has been evidenced by comparison with homogeneous oxidations. 相似文献
2.
Fatin N. Mohd Jaya Sergio G. Garcia Francesc E. Borras Dolores Guerrero Godfrey C. F. Chan Marcella Franquesa 《International journal of molecular sciences》2021,22(9)
Regulatory B (Breg) cells are endowed with immune suppressive functions. Various human and murine Breg subtypes have been reported. While interleukin (IL)-10 intracellular staining remains the most reliable way to identify Breg cells, this technique hinders further essential functional studies. Recent findings suggest that CD9 is an effective surface marker of murine IL-10 competent Breg cells. However, the stability of CD9 and its relevance as a unique marker for human Breg cells, which have been widely characterized as CD24hiCD38hi, have not been investigated. Here, we demonstrate that CD9 expression is sensitive to in vitro B cell stimulations. CD9 expression could either be re-expressed or downregulated in purified CD9-negative B cells and CD9-positive B cells, respectively. We found no significant differences in the Breg differentiation capacity of the CD9-negative and CD9-positive B cells. Furthermore, CD9-positive B cells co-express CD40 and CD86, suggesting their nature as B cell activation or co-stimulatory molecules, rather than regulatory ones. Therefore, we report the relatively unstable CD9 as a distinct surface molecule, indicating the need for further research for a more reliable marker to purify human Breg cells. 相似文献
3.
Enrique Alfonseca Guillermo Garrido Jean-Yves Delort Anselmo Peñas 《Language Resources and Evaluation》2013,47(4):1163-1190
This paper describes the generation of temporally anchored infobox attribute data from the Wikipedia history of revisions. By mining (attribute, value) pairs from the revision history of the English Wikipedia we are able to collect a comprehensive knowledge base that contains data on how attributes change over time. When dealing with the Wikipedia edit history, vandalic and erroneous edits are a concern for data quality. We present a study of vandalism identification in Wikipedia edits that uses only features from the infoboxes, and show that we can obtain, on this dataset, an accuracy comparable to a state-of-the-art vandalism identification method that is based on the whole article. Finally, we discuss different characteristics of the extracted dataset, which we make available for further study. 相似文献
4.
The statistical properties of the autoregressive (AR) distance between ARIMA processes are investigated. In particular, the asymptotic distribution of the squared AR distance and an approximation which is computationally efficient are derived. Moreover, the problem of time series clustering and classification is discussed and the performance of the AR distance is illustrated by means of some empirical applications. 相似文献
5.
Paulo Anselmo da Mota Silveira Neto Ivan do Carmo Machado John D. McGregorEduardo Santana de Almeida Silvio Romero de Lemos Meira 《Information and Software Technology》2011,53(5):407-423
Context
In software development, Testing is an important mechanism both to identify defects and assure that completed products work as specified. This is a common practice in single-system development, and continues to hold in Software Product Lines (SPL). Even though extensive research has been done in the SPL Testing field, it is necessary to assess the current state of research and practice, in order to provide practitioners with evidence that enable fostering its further development.Objective
This paper focuses on Testing in SPL and has the following goals: investigate state-of-the-art testing practices, synthesize available evidence, and identify gaps between required techniques and existing approaches, available in the literature.Method
A systematic mapping study was conducted with a set of nine research questions, in which 120 studies, dated from 1993 to 2009, were evaluated.Results
Although several aspects regarding testing have been covered by single-system development approaches, many cannot be directly applied in the SPL context due to specific issues. In addition, particular aspects regarding SPL are not covered by the existing SPL approaches, and when the aspects are covered, the literature just gives brief overviews. This scenario indicates that additional investigation, empirical and practical, should be performed.Conclusion
The results can help to understand the needs in SPL Testing, by identifying points that still require additional investigation, since important aspects regarding particular points of software product lines have not been addressed yet. 相似文献6.
7.
8.
Erick Corrêa da Silva Aristófanes Corrêa Silva Anselmo Cardoso de Paiva Rodolfo Acatauassu Nunes 《Pattern Analysis & Applications》2008,11(1):89-99
This paper analyzes the application of Moran’s index and Geary’s coefficient to the characterization of lung nodules as malignant
or benign in computerized tomography images. The characterization method is based on a process that verifies which combination
of measures, from the proposed measures, has been best able to discriminate between the benign and malignant nodules using
stepwise discriminant analysis. Then, a linear discriminant analysis procedure was performed using the selected features to
evaluate the ability of these in predicting the classification for each nodule. In order to verify this application we also
describe tests that were carried out using a sample of 36 nodules: 29 benign and 7 malignant. A leave-one-out procedure was
used to provide a less biased estimate of the linear discriminator’s performance. The two analyzed functions and its combinations
have provided above 90% of accuracy and a value area under receiver operation characteristic (ROC) curve above 0.85, that
indicates a promising potential to be used as nodules signature measures. The preliminary results of this approach are very
encouraging in characterizing nodules using the two functions presented.
相似文献
Rodolfo Acatauassu NunesEmail: |
9.
Mashburn DN Hinkson SJ Woods MC Gilligan JM Holcomb MR Wikswo JP 《The Review of scientific instruments》2007,78(10):104302
Defibrillators are a critical tool for treating heart disease; however, the mechanisms by which they halt fibrillation are still not fully understood and are the subject of ongoing research. Clinical defibrillators do not provide the precise control of shock timing, duration, and voltage or other features needed for detailed scientific inquiry, and there are few, if any, commercially available units designed for research applications. For this reason, we have developed a high-voltage, programmable, capacitive-discharge stimulator optimized to deliver defibrillation shocks with precise timing and voltage control to an isolated animal heart, either in air or in a bath. This stimulator is capable of delivering voltages of up to 500 V and energies of nearly 100 J with timing accuracy of a few microseconds and with rise and fall times of 5 micros or less and is controlled only by two external timing pulses and a control computer that sets the stimulation parameters via a LABVIEW interface. Most importantly, the stimulator has circuits to protect the high-voltage circuitry and the operator from programming and input-output errors. This device has been tested and used successfully in field shock experiments on rabbit hearts as well as other protocols requiring high voltage. 相似文献
10.
Marcelo Ozu Juan Jos Alvear-Arias Miguel Fernandez Agustín Caviglia Antonio Pea-Pichicoi Christian Carrillo Emerson Carmona Anselmo Otero-Gonzalez Jos Antonio Garate Gabriela Amodeo Carlos Gonzalez 《International journal of molecular sciences》2022,23(20)
Aquaporins (AQPs) are small transmembrane tetrameric proteins that facilitate water, solute and gas exchange. Their presence has been extensively reported in the biological membranes of almost all living organisms. Although their discovery is much more recent than ion transport systems, different biophysical approaches have contributed to confirm that permeation through each monomer is consistent with closed and open states, introducing the term gating mechanism into the field. The study of AQPs in their native membrane or overexpressed in heterologous systems have experimentally demonstrated that water membrane permeability can be reversibly modified in response to specific modulators. For some regulation mechanisms, such as pH changes, evidence for gating is also supported by high-resolution structures of the water channel in different configurations as well as molecular dynamics simulation. Both experimental and simulation approaches sustain that the rearrangement of conserved residues contributes to occlude the cavity of the channel restricting water permeation. Interestingly, specific charged and conserved residues are present in the environment of the pore and, thus, the tetrameric structure can be subjected to alter the positions of these charges to sustain gating. Thus, is it possible to explore whether the displacement of these charges (gating current) leads to conformational changes? To our knowledge, this question has not yet been addressed at all. In this review, we intend to analyze the suitability of this proposal for the first time. 相似文献