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排序方式: 共有48条查询结果,搜索用时 31 毫秒
1.
Prof. Alessia Carocci Dr. Mariagrazia Roselli Prof. Roberta Budriesi Dr. Matteo Micucci Prof. Jean-François Desaphy Dr. Concetta Altamura Dr. Maria Maddalena Cavalluzzi Dr. Maddalena Toma Dr. Giovanna Ilaria Passeri Dr. Gualtiero Milani Dr. Angelo Lovece Prof. Alessia Catalano Dr. Claudio Bruno Dr. Annalisa De Palma Prof. Filomena Corbo Prof. Carlo Franchini Prof. Solomon Habtemariam Prof. Giovanni Lentini 《ChemMedChem》2021,16(3):578-588
Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5-tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual-acting drugs potentially useful in the protection of the heart against post-ischemic reperfusion injury. The pyrroline derivatives reported herein were found to be more potent as antiarrhythmic agents than mexiletine and displayed antioxidant activity. The most interesting tetramethylpyrroline congener, a tert-butyl-substituted analogue, was at least 100 times more active as an antiarrhythmic than mexiletine. 相似文献
2.
The execution of workflow processes requires authorizations for enforcing the assignment of tasks to agents, either human or automated, according to the security policy of the organization. This paper presents a workflow authorization framework based on roles and organizational levels, and on authorization constraints. To facilitate the assignment of tasks to agents, roles and organizational levels are organized into hierarchies. Authorization constraints are introduced to specify instance-dependent, time-dependent, and history-dependent authorizations. Authorization constraints are specified in terms of active rules, used also for authorization management. The Workflow Management System determines authorized agents on the basis of the contents of an authorization base maintained through the active rules defined in the system. 相似文献
3.
Fabio Casati Maria Grazia Fugini Isabelle Mirbel Barbara Pernici 《Requirements Engineering》2002,7(2):73-106
Workflow management systems are becoming a relevant support for a large class of business applications, and many workflow
models as well as commercial products are currently available. While the large availability of tools facilitates the development
and the fulfilment of customer requirements, workflow application development still requires methodological guidelines that
drive the developers in the complex task of rapidly producing effective applications. In fact, it is necessary to identify
and model the business processes, to design the interfaces towards existing cooperating systems, and to manage implementation
aspects in an integrated way. This paper presents the WIRES methodology for developing workflow applications under a uniform
modelling paradigm – UML modelling tools with some extensions – that covers all the life cycle of these applications: from
conceptual analysis to implementation. High-level analysis is performed under different perspectives, including a business and an organisational perspective. Distribution, interoperability and cooperation with external information systems are considered in this early
stage. A set of “workflowability” criteria is provided in order to identify which candidate processes are suited to be implemented
as workflows. Non-functional requirements receive particular emphasis in that they are among the most important criteria for
deciding whether workflow technology can be actually useful for implementing the business process at hand. The design phase
tackles aspects of concurrency and cooperation, distributed transactions and exception handling. Reuse of component workflows,
available in a repository as workflow fragments, is a distinguishing feature of the method. Implementation aspects are presented
in terms of rules that guide in the selection of a commercial workflow management system suitable for supporting the designed
processes, coupled with guidelines for mapping the designed workflows onto the model offered by the selected system. 相似文献
4.
Buccafurri Francesco De Meo Pasquale Lax Gianluca Ursino Domenico Fugini Mariagrazia Modafferi Stefano Pernici Barbara Furnari Roberto Goy Anna Lops Pasquale Redavid Domenico Semeraro Giovanni 《Multimedia, IEEE》2009,16(1):26-35
An integrated approach to quality of service for content delivery using Web services includes quality definitions, user contracts, and fault monitoring. 相似文献
5.
Mariagrazia Fortino Alessandro Berselli Nicholas Stone-Weiss Lu Deng Ashutosh Goel Jincheng Du Alfonso Pedone 《Journal of the American Ceramic Society》2019,102(12):7225-7243
Borates and borosilicates are potential candidates for the design and development of glass formulations with important industrial and technological applications. A major challenge that retards the pace of development of borate/borosilicate based glasses using predictive modeling is the lack of reliable computational models to predict the structure-property relationships in these glasses over a wide compositional space. A major hindrance in this pursuit has been the complexity of boron-oxygen bonding due to which it has been difficult to develop adequate B–O interatomic potentials. In this article, we have evaluated the performance of three B–O interatomic potential models recently developed by Bauchy et al [J. Non-Cryst. Solids, 2018, 498, 294–304], Du et al [J. Am. Ceram. Soc. https://doi.org/10.1111/jace.16082 ] and Edèn et al [Phys. Chem. Chem. Phys., 2018, 20, 8192–8209] aiming to reproduce the short-to-medium range structures of sodium borosilicate glasses in the system 25 Na2O x B2O3 (75 − x) SiO2 (x = 0-75 mol%). To evaluate the different force fields, we have computed at the density functional theory level the NMR parameters of 11B, 23Na, and 29Si of the models generated with the three potentials and the simulated MAS NMR spectra compared with the experimental counterparts. It was observed that the rigid ionic models proposed by Bauchy and Du can both reliably reproduce the partitioning between BO3 and BO4 species of the investigated glasses, along with the local environment around sodium in the glass structure. However, they do not accurately reproduce the second coordination sphere of silicon ions and the Si–O–T (T = Si, B) and B-O-T distribution angles in the investigated compositional space which strongly affect the NMR parameters and final spectral shape. On the other hand, the core-shell parameterization model proposed by Edén underestimates the fraction of BO4 species of the glass with composition 25Na2O 18.4B2O3 56.6SiO2 but can accurately reproduce the shape of the 11B and 29Si MAS-NMR spectra of the glasses investigations due to the narrower B–O–T and Si-O-T bond angle distributions. Finally, the effect of the number of boron atoms (also distinguishing the BO3 and BO4 units) in the second coordination sphere of the network former cations on the NMR parameters have been evaluated. 相似文献
6.
This paper provides a survey of the main advanced control techniques currently adopted in factory automation. In particular, it focuses on five classes of control approaches, namely: model-based control, control based on computational intelligence, adaptive control, discrete event systems-based control and finally event-triggered and self-triggered control. A particular focus is put on the most significant and recent contributions in these areas with attention to their application in the factory automation domain. Finally, open issues, challenges and the requirements of further research efforts for each class are pointed out. 相似文献
7.
The paper defines the identification problem for Discrete Event Systems (DES) as the problem of inferring a Petri Net () model using the observation of the events and the available output vectors, that correspond to the markings of the measurable places. Two cases are studied considering different levels of the system knowledge. In the first case the place and transition sets are assumed known. Hence, an integer linear programming problem is defined in order to determine a modelling the DES. In the second case the transition and place sets are assumed unknown and only an upper bound of the number of places is given. Hence, the identification problem is solved by an identification algorithm that observes in real time the occurred events and the corresponding output vectors. The integer linear programming problem is defined at each observation so that the can be recursively identified. Some results and examples characterize the identified systems and show the flexibility and simplicity of the proposed technique. Moreover, an application to the synthesis of supervisory control of systems via monitor places is proposed. 相似文献
8.
This paper addresses the problem of identifying the model of the unobservable behaviour of discrete event systems in the industrial automation sector. Assuming that the fault-free system structure and dynamics are known, the paper proposes an algorithm that monitors the system on-line, storing the occurred observable event sequence and the corresponding reached states. At each event observation, the algorithm checks whether some unobservable events have occurred on the basis of the knowledge of the Petri net (PN) modelling the nominal system behaviour and the knowledge of the current PN marking. By defining and solving some integer linear programming problems, the algorithm decides whether it is necessary to introduce some unobservable (silent) transitions in the PN model and provides a PN structure that is consistent with the observed event string. A case study describing an industrial automation system shows the efficiency and the applicability of the proposed algorithm. 相似文献
9.
Daria Brambilla Cesare Mancuso Mariagrazia Rita Scuderi Paolo Bosco Giuseppina Cantarella Laurence Lempereur Giulia Di Benedetto Salvatore Pezzino Renato Bernardini 《Nutrition journal》2008,7(1):29
This review will discuss some issues related to the risk/benefit profile of the use of dietary antioxidants. Thus, recent
progress regarding the potential benefit of dietary antioxidants in the treatment of chronic diseases with a special focus
on immune system and neurodegenerative disorders will be discussed here. It is well established that reactive oxygen species
(ROS) play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes and cancer. Among the
physiological defense system of the cell, the relevance of antioxidant molecules, such as glutathione and vitamins is quite
well established. Recently, the interest of researchers has, for example, been conveyed on antioxidant enzyme systems, such
as the heme oxygenase/biliverdin reductase system, which appears modulated by dietary antioxidant molecules, including polyphenols
and beta-carotene. These systems possibly counteract oxidative damage very efficiently and finally modulate the activity of
oxidative phenomena occurring, for instance, during pathophysiological processes. Although evidence shows that antioxidant
treatment results in cytoprotection, the potential clinical benefit deriving from both nutritional and supplemental antioxidants
is still under wide debate. In this line, the inappropriate assumption of some lipophylic vitamins has been associated with
increased incidence of cancer rather than with beneficial effects. 相似文献
10.
Mariagrazia Dotoli Maria P. Fanti Agostino M. Mangini Gabriella Stecco Walter Ukovich 《Control Engineering Practice》2010,18(8):893-903
The paper addresses the issues of modelling and managing Intermodal Transportation Systems (ITS) at the operational level, considering the impact of the new Information and Communication Technologies (ICT). ITS are regarded as discrete event systems and are modelled in a timed Petri net framework. In order to show the efficiency of the ITS modelling and controlling technique, the case study of the ferry terminal of Trieste (Italy) is considered. The results show that the approach can be employed to verify the potential of ICT for efficient real time management of ITS, and their impact on the ITS infrastructures. 相似文献