Left and Right Pathlengths in Random Binary Trees

We study the difference between the left and right total pathlengths in a random binary tree. The results include exact and asymptotic formulas for moments and an asymptotic distribution that can be expressed in terms of either the Brownian snake or ISE. The proofs are based on computing expectations for a subcritical binary Galton-Watson tree, and studying asymptotics as the Galton-Watson process approaches a critical one.     

Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies

We have shown previously that expression of mRNA for somatostatin receptor subtype 2 (sst2) detected by in situ hybridization correlates to therapeutic outcome in patients with carcinoid tumors treated with somatostatin analogues. However, in situ hybridization is laborious and not practical in clinical routine work. We have, therefore, developed polyclonal antibodies directed against sst2 that may be used for immunohistochemistry on tissue specimens. The staining is specific and is highly correlated to expression of mRNA for sst2 (P < 0.01) as well as to tracer uptake at somatostatin receptor scintigraphy (P < 0.01). There is also a good correlation to the therapeutic response in carcinoid patients treated with somatostatin analogues (P < 0.05). Of 35 patients with carcinoid tumors included in this investigation, 25 stained positive with the antibodies. Twenty-two of these were investigated by somatostatin receptor scintigraphy and showed tracer uptake in metastases. An additional two patients that did not stain with the antibodies showed pathological uptake of the tracer in metastases, which might indicate binding to somatostatin receptor subtype 5. None of the 10 patients without positive immunostaining responded to somatostatin analogue treatment, whereas patients with a positive stain had a biochemical response or remained stable during treatment. Thus, these antibodies may be used to determine the presence of sst2 in carcinoid tumors and to select patients suitable for somatostatin analogue treatment. The method is easily applicable in clinical practice.     

PShare: Ensuring location privacy in non-trusted systems through multi-secret sharing

Location-based applications such as Facebook Places, Foursquare, or Loopt typically use location services to manage mobile object positions. However, exposing precise user positions raises user privacy concerns, especially if location service providers are not fully trusted. To enable the secure management of private user positions in non-trusted systems, we present two novel position sharing approaches based on the concept of multi-secret sharing. We improve existing geometric position sharing approaches by Dürr et al. [2] and Skvortsov et al. [3] by considering continuous position updates and by increasing the robustness against various attacks. Furthermore, we present the first position sharing approach for symbolic location models.     

Ultraviolet photodetectors and readout based on a-IGZO semiconductor technology

In this work, real-time ultraviolet photodetectors are realized through metal–semiconductor–metal (MSM) structures. Amorphous indium gallium zinc oxide (a-IGZO) is used as semiconductor material and gold as metal electrodes. The readout of an individual sensor is implemented by a transimpedance amplifier (TIA) consisting of an all-enhancement a-IGZO thin-film transistor (TFT) operational amplifier and a switched capacitor (SC) as feedback resistance. The photosensor and the transimpedance amplifier are both manufactured on glass substrates. The measured photosensor possesses a high responsivity R , a low response time t _{R E S} , and a good noise equivalent power value NEP .     

Modelling and condition-based control of a flexible and hybrid disassembly system with manual and autonomous workstations using reinforcement learning

Journal of Intelligent Manufacturing - Remanufacturing includes disassembly and reassembly of used products to save natural resources and reduce emissions. While assembly is widely understood in...     

Recovering the initial state of an infinite-dimensional system using observers

Let A be the generator of a strongly continuous semigroup T on the Hilbert space X, and let C be a linear operator from D(A) to another Hilbert space Y (possibly unbounded with respect to X, not necessarily admissible). We consider the problem of estimating the initial state z₀∈D(A) (with respect to the norm of X) from the output function y(t)=CT_tz₀, given for all t in a bounded interval [0,τ]. We introduce the concepts of estimatability and backward estimatability for (A,C) (in a more general way than currently available in the literature), we introduce forward and backward observers, and we provide an iterative algorithm for estimating z₀ from y. This algorithm generalizes various algorithms proposed recently for specific classes of systems and it is an attractive alternative to methods based on inverting the Gramian. Our results lead also to a very general formulation of Russell’s principle, i.e., estimatability and backward estimatability imply exact observability. This general formulation of the principle does not require T to be invertible. We illustrate our estimation algorithms on systems described by wave and Schrödinger equations, and we provide results from numerical simulations.     

An empirical investigation of architectural prototyping

Architectural prototyping is the process of using executable code to investigate stakeholders’ software architecture concerns with respect to a system under development. Previous work has established this as a useful and cost-effective way of exploration and learning of the design space of a system and in addressing issues regarding quality attributes, architectural risks, and the problem of knowledge transfer and conformance. However, the actual industrial use of architectural prototyping has not been thoroughly researched so far. In this article, we report from three studies of architectural prototyping in practice. First, we report findings from an ethnographic study of practicing software architects. Secondly, we report from a focus group on architectural prototyping involving architects from four companies. And, thirdly, we report from a survey study of 20 practicing software architects and software developers. Our findings indicate that architectural prototyping plays an important and frequent role in resolving problems experimentally, but less so in exploring alternative solutions. Furthermore, architectural prototypes include end-user or business related functionality rather than purely architectural functionality. Based on these observations we provide recommendations for effective industrial architectural prototyping.