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1.
Tammy L. Smith Divakaran Masilamani Long Kim Bui Raymond Brambilla Yash P. Khanna Kristina A. Garbriel 《应用聚合物科学杂志》1994,52(5):591-596
Nucleating agents increase the impact strength, tensile strength, and tensile elasticity modulus of semicrystalline polymers. Nucleating agents also decrease product cycle times, resulting in a cost savings per product unit. We have synthesized and tested 15 compounds as nucleactors for polypropylene. Of these, trinapthylidene sorbitol, tri-(4-methyl-1-naphthylidene)sorbitol, tri-(4-methoxy-1-naphthylidene) sorbitol, and dibenzylidene xylitol are efficient nucleators of polypropylene. Trinaphthylidene sorbitol (tns) has two major diastereomers: The “S” diastereomer yields a faster crystallization rate for polypropylene than does the commercial nucleator dibenzylidene sorbitol (Millad 3905). Crystallization rates are 208 and 88, respectively (t min?1 × 1000). The “R” diastereomer, however, is a poor nucleator and interferes with the nucleating activity of the “S” diastereomer. A 52/48 mixture of diastereomers does not nucleate polypropylene, even at twice the concentration. This is first time that the importance of stereochemistry has been demonstrated in the nucleating action. © 1994 John Wiley & Sons, Inc. 相似文献
2.
GH Kim S Masilamani R Turner C Mitchell JB Wade MA Knepper 《Canadian Metallurgical Quarterly》1998,95(24):14552-14557
Although the collecting duct is regarded as the primary site at which mineralocorticoids regulate renal sodium transport in the kidney, recent evidence points to the distal convoluted tubule as a possible site of mineralocorticoid action. To investigate whether mineralocorticoids regulate the expression of the thiazide-sensitive Na-Cl cotransporter (TSC), the chief apical sodium entry pathway of distal convoluted tubule cells, we prepared an affinity-purified, peptide-directed antibody to TSC. On immunoblots, the antibody recognized a prominent 165-kDa band in membrane fractions from the renal cortex but not from the renal medulla. Immunofluorescence immunocytochemistry showed TSC labeling only in distal convoluted tubule cells. Semiquantitative immunoblotting studies demonstrated a large increase in TSC expression in the renal cortex of rats on a low-NaCl diet (207 +/- 21% of control diet). Immunofluorescence localization in tissue sections confirmed the strong increase in TSC expression. Treatment of rats for 10 days with a continuous subcutaneous infusion of aldosterone also increased TSC expression (380 +/- 58% of controls). Furthermore, 7-day treatment of rats with an orally administered mineralocorticoid, fludrocortisone, increased TSC expression (656 +/- 114% of controls). We conclude that the distal convoluted tubule is an important site of action of the mineralocorticoid aldosterone, which strongly up-regulates the expression of TSC. 相似文献
3.
A Muruganandam LM Herx R Monette JP Durkin DB Stanimirovic 《Canadian Metallurgical Quarterly》1997,11(13):1187-1197
The objective of this study was to generate an immortal cell line representative of specialized human brain microvascular endothelia forming the blood-brain barrier (BBB) in vivo. Human capillary and microvascular endothelial cells (HCEC) were transfected with the plasmid pSV3-neo coding for the SV40 large T antigen and the neomycin gene. The neomycin-resistant transfected cells overcame proliferative senescence, and after a 6-8 wk period of crisis produced immortalization-competent cell colonies. Single-cell clones of near-diploid genotype were isolated from these colonies, propagated, and characterized. Immortalized HCEC (SV-HCEC) exhibited accelerated proliferation rates, but remained serum and anchorage dependent and retained the characteristic cobblestone morphology at confluence. SV-HCEC displayed a stable nuclear expression of SV40 large T antigen, lacked the invasiveness of transformed cells, and maintained major phenotypic properties of early passage control cells including expression of factor VIII-related antigen, uptake of acetylated low-density lipoprotein, binding of fluorescently labeled lectins, expression of transferrin receptor and transferrin receptor-mediated endocytosis, and high activities of the BBB-specific enzymes alkaline phosphatase and gamma-glutamyl transpeptidase. The diffusion of radiolabeled sucrose across SV-HCEC monolayers was fivefold lower than that observed with human lung microvascular endothelial cells. Furthermore, media conditioned by fetal human astrocytes increased the transendothelial electrical resistance of SV-HCEC monolayers by 2.5-fold. Therefore, this newly established human cell line expressing the specialized phenotype of BBB endothelium may serve as a readily available in vitro model for studying the properties of the human BBB. 相似文献
4.
S. Muruganandam S. Pugazhenthi 《The International Journal of Advanced Manufacturing Technology》2010,46(5-8):801-810
Parallel kinematic machine tools (PKM) have the advantages of higher stiffness, higher payload capacity and lower inertia. Still their penetration into the machine tool industry is very less. One of the difficulties in using PKMs such as hexapod machine tools is that the stiffness continuously varies with configuration change at every instant. This makes location of work piece and selection of machining parameters difficult and complicated. A methodology is presented in this article to select optimal machining parameters for hexapod machine tools. Particle swarm optimization is used as a tool in the optimization process. A profile-milling example is also presented to demonstrate the selection of machining parameters. 相似文献
5.
Kanagasabai Muruganandam Ponvel Dhamodaran Kavitha Kyung-Min Kim Chang-Ha Lee 《Korean Journal of Chemical Engineering》2009,26(5):1379-1382
To remove 2,4-dichlorophenol (2,4-DCP) from aqueous solution, the surface of the activated carbon was first treated with HCl
and then the surface was modified by using various metal ions (Cu, Co, Fe, Ni, Zn, and Mg). Metal doping significantly enhanced
the adsorption efficiency of activated carbon, an effect that was further increased by HCl treatment of the modified activated
carbons. Of all the preparations, the zinc(II)-modified activated carbon with HCl treatment showed the highest adsorption
capacity for 2,4-DCP. Analysis of the zinc(II)-modified activated carbon by SEM and BET showed a surface area and micropore
volume of around 1,154.69 m2/g and 0.291 cm3/g, respectively, values about 20% higher than in the starting material. In the pH range of 2.0–11.0, the maximum uptake of
2,4-DCP from an initial concentration of 1,000 mg/L was 508 mg/g at pH 4.0. 相似文献
6.
Uma Palanisamy Hwee Ming Cheng Theanmalar Masilamani Thavamanithevi Subramaniam Lai Teng Ling Ammu K. Radhakrishnan 《Food chemistry》2008
The rind of rambutan, which is normally discarded was found to contain extremely high antioxidant activity when assessed using several methods. Although having a yield of only 18%, the ethanolic rambutan rind extract had a total phenolic content of 762 ± 10 mg GAE/g extract, which is comparable to that of a commercial preparation of grape seed extract. Comparing the extract’s pro-oxidant capabilities with vitamin C, α-tocopherol, grape seed and green tea, the rind had the lowest pro-oxidant capacity. In addition, the extract at 100 μg/ml was seen to limit oxidant-induced cell death (DPPH at 50 μM) by apoptosis to an extent similar to that of grape seed. The extracts were not cytotoxic to normal mouse fibroblast cells or splenocytes while the powderised rind was seen to have heavy metals contents far below the permissible levels for nutraceuticals. Our study for the first time reveals the high phenolic content, low pro-oxidant capacity and strong antioxidant activity of the extract from rind of Nephelium lappaceum. This extract, either alone or in combination with other active principles, can be used in cosmetic, nutraceutical and pharmaceutical applications. 相似文献
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8.
R.J. Byron Smith L. Muruganandam S. Murthy Shekhar 《Chemical Engineering Research and Design》2011,89(11):2448-2456
Fuel cell based modular power generation can be achieved by miniaturization and process intensification of equipments in the process. Fuel cells require hydrogen rich gas which can be generated through reforming and water gas shift reaction. The water gas shift reactor being kinetically limited occupies more volume to achieve the required CO conversion. A membrane reactor integrates the reaction and hydrogen separation stages and hence reduces the volume requirement. Computational Fluid Dynamics offers virtual prototyping of the reactor and thus helps in design, optimization and scale up of reactors. In this study customized User Defined Functions (UDFs) were developed to analyze the performance of low temperature water gas shift membrane reactor. The models were validated using literature data for the parameters – synthesis gas compositions, time factor, sweep flow rate and steam to CO ratio. The effect of all these parameters on the reactor was analyzed for CO conversion, H2 recovery, DaPe, concentration polarization, concentration profiles and conversion index. The simulations have showed that the UDFs developed were capable of simulating the membrane reactor and this can be used for the design and optimization of the membrane reactor for any process conditions. 相似文献
9.
Nikhil V.V. Abhilash Nair Niketh P Amit Kumar Muruganandam T.M. 《Microgravity science and technology》2018,30(5):663-673
Space missions involving humans require a better understanding of various phenomena happening in space environments. A number of experiments need to be conducted in microgravity for addressing various issues encompassing safety (primarily fire) and better understanding of fluid and material behaviour. Of the various methods used for obtaining microgravity conditions, drop towers offer ground based microgravity platform. They provide a cost effective platform for doing short duration, repeatable, high quality microgravity experiments. This paper describes key factors that influence the design of a drop tower. The salient features of 2.5 s microgravity tower set up at National Centre for Combustion Research and Development (NCCRD), IIT Madras (IITM) are discussed. Primary features of the three critical elements, namely the drop capsule, the release unit and the decelerator unit are described along with review of these elements in existing drop towers. The IITM drop tower operates in ambient atmospheric conditions to minimise the cost of operation. In order to achieve good quality microgravity levels, a dual capsule configuration is adopted. The shape of the outer capsule is arrived at by detailed transient computational fluid dynamic analysis of the drag shield under free fall condition over the drop height. A pneumatic mechanism is used for capsule release and brought to rest at the end of fall in a carefully designed decelerator unit. The decelerator unit consists of an airbag with controlled air outflow for smooth deceleration. 相似文献
10.
Multimedia Tools and Applications - Image quality assessment is very crucial for certain image processing applications. Images can be distorted from multiple sources like a fault in sensors, camera... 相似文献