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Krishna Tushar Kumar Amit Peh Li-Shiuan Postman Jacob Chiang Patrick Erez Mattan 《Micro, IEEE》2009,29(4):48-61
Networks on chip must deliver high bandwidth at low latencies while keeping within a tight power envelope. Using express virtual channels for flow control improves energy-delay throughput by letting packets bypass intermediate routers, but EVCs have key limitations. Nochi (NoC with hybrid interconnect) overcomes these limitations by transporting data payloads and control information on separate planes, optimized for bandwidth and latency respectively. 相似文献
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Cover Picture: Covalent Inhibition of HIV‐1 Integrase by N‐Succinimidyl Peptides (ChemMedChem 18/2016) 下载免费PDF全文
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Hoffman JR Williams DR Emerson NS Hoffman MW Wells AJ McVeigh DM McCormack WP Mangine GT Gonzalez AM Fragala MS 《Journal of the International Society of Sports Nutrition》2012,9(1):4-8
Background
The purpose of this study was to examine the efficacy of L-alanyl-L-glutamine (AG) ingestion on basketball performance, including jump power, reaction time, shooting accuracy and fatigue.Methods
Ten women (21.2 ± 1.6 years; height: 177.8 ± 8.7 cm; body mass: 73.5 ± 8.0 kg), all scholarship NCAA Division I basketball players, volunteered for this study. Subjects participated in four trials, each consisting of a 40-min basketball game with controlled time-outs for rehydration. During the first trial (DHY) subjects were not allowed to rehydrate, and the total weight lost during the contest was used to determine fluid replenishment during the subsequent three trials. During one trial subjects consumed only water (W), while during the other two trials subjects consumed the AG supplement mixed in water using either a low dose (1 g per 500 ml) (AG1) or high dose (2 g per 500 ml) (AG2) concentration. All data assessed prior to and following each game were converted into a ?? score (Post results - Pre results). All performance data were then analyzed using a one-way repeated measures analysis of variance.Results
During DHY subjects lost 1.72 ± 0.42 kg (2.3%) of their body mass. No differences in fluid intake (1.55 ± 0.43 L) were seen between rehydration trials. A 12.5% (p = 0.016) difference in basketball shooting performance was noted between DHY and AG1 and an 11.1% (p = 0.029) difference was seen between AG1 and W. Visual reaction time was significantly greater following AG1 (p = 0.014) compared to DHY. Differences (p = 0.045) in fatigue, as determined by player loads, were seen only between AG2 and DHY. No differences were seen in peak or mean vertical jump power during any trial.Conclusion
Rehydration with AG appears to maintain basketball skill performance and visual reaction time to a greater extent than water only. 相似文献5.
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Francesco Brunori Dr. Deepak Kumar Padhi Israel Alshanski Dr. Joanna Freyse Jan-Niklas Dürig Anja Penk Prof. Luigi Vaccaro Dr. Mattan Hurevich Prof. Jörg Rademann Prof. Shlomo Yitzchaik 《Chembiochem : a European journal of chemical biology》2022,23(3):e202100552
Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns. In some cases, these interactions are mediated by metal ion binding which can be used to tune surface-based glycan-protein interactions. We evaluated the effect of both hyaluronan sulfation degree and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations. Our results show that sulfation degree and metal ion interactions have a synergistic effect in tuning the electrochemical response of the glycated surfaces to the cytokine. 相似文献
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Dr. Koushik Chandra Dr. Priyadip Das Dr. Samarasimhareddy Mamidi Dr. Mattan Hurevich Anat Iosub‐Amir Dr. Norman Metanis Dr. Meital Reches Prof. Assaf Friedler 《ChemMedChem》2016,11(18):1987-1994
We present a new approach for the covalent inhibition of HIV‐1 integrase (IN) by an LEDGF/p75‐derived peptide modified with an N‐terminal succinimide group. The covalent inhibition is mediated by direct binding of the succinimide to the amine group of a lysine residue in IN. The peptide serves as a specific recognition sequence for the target protein, while the succinimide serves as the binding moiety. The combination of a readily synthesizable peptide precursor with easy and efficient binding to the target protein makes this approach a promising new strategy for designing lead compounds. 相似文献
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Jay R Hoffman Jie Kang Nicholas A Ratamess Mattan W Hoffman Christopher P Tranchina Avery D Faigenbaum 《Journal of the International Society of Sports Nutrition》2009,6(1):1-8
Background
The purpose of the present study was to examine the acute effects of a thermogenic nutritional supplement containing caffeine, capsaicin, bioperine, and niacin on muscular strength and endurance performance.Methods
Twenty recreationally-active men (mean ± SD age = 21.5 ± 1.4 years; stature = 178.2 ± 6.3 cm; mass = 76.5 ± 9.9 kg; VO2 PEAK = 3.05 ± 0.59 L/min-1) volunteered to participate in this randomized, double-blinded, placebo-controlled, cross-over study. All testing took place over a three-week period, with each of the 3 laboratory visits separated by 7 days (± 2 hours). During the initial visit, a graded exercise test was performed on a Lode Corival cycle ergometer (Lode, Groningen, Netherlands) until exhaustion (increase of 25 W every 2 min) to determine the maximum power output (W) at the VO2 PEAK (Parvo Medics TrueOne® 2400 Metabolic Measurement System, Sandy, Utah). In addition, one-repetition maximum (1-RM) strength was assessed using the bench press (BP) and leg press (LP) exercises. During visits 2 and 3, the subjects were asked to consume a capsule containing either the active supplement (200 mg caffeine, 33.34 mg capsaicin, 5 mg bioperine, and 20 mg niacin) or the placebo (175 mg of calcium carbonate, 160 mg of microcrystalline cellulose, 5 mg of stearic acid, and 5 mg of magnesium stearate in an identical capsule) 30 min prior to the testing. Testing included a time-to-exhaustion (TTE) ride on a cycle ergometer at 80% of the previously-determined power output at VO2 PEAK followed by 1-RM LP and BP tests.Results
There were no differences (p > 0.05) between the active and placebo trials for BP, LP, or TTE. However, for the BP and LP scores, the baseline values (visit 1) were less than the values recorded during visits 2 and 3 (p ≤ 0.05).Conclusion
Our findings indicated that the active supplement containing caffeine, capsaicin, bioperine, and niacin did not alter muscular strength or cycling endurance when compared to a placebo trial. The lack of increases in BP and LP strength and cycle ergometry endurance elicited by this supplement may have been related to the relatively small dose of caffeine, the high intensity of exercise, the untrained status of the participants, and/or the potential for caffeine and capsaicin to increase carbohydrate oxidation. 相似文献9.
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Jay R Hoffman Jie Kang Nicholas A Ratamess Mattan W Hoffman Christopher P Tranchina Avery D Faigenbaum 《Journal of the International Society of Sports Nutrition》2009,6(1):2