Formal methods integration for the specification of dependable distributed systems

This paper describes a real-world case study in the specification and analysis of dependable distributed systems. The case study is an automated transport system with safety requirements. In order to manage the complexity of the problem of specifying the dynamic behavior of the whole system, a compositional approach is used, based on the integration of the trace logic of the Communicating Sequential Processes (CSP) theory, and stochastic Petri nets (SPNs). It is argued that the integration of different formal methods is a useful approach in the definition of practical engineering methodologies for the specification, design and analysis of complex dependable distributed systems.     

The Adaptability of Chromosomal Instability in Cancer Therapy and Resistance

Variation in chromosome structure is a central source of DNA damage and DNA damage response, together representinga major hallmark of chromosomal instability. Cancer cells under selective pressure of therapy use DNA damage and DNA damage response to produce newfunctional assets as an evolutionary mechanism. Recent efforts to understand DNA damage/chromosomal instability and elucidate its role in initiation or progression of cancer have also disclosed its vulnerabilities represented by inappropriate DNA damage response, chromatin changes, andinflammation. Understanding these vulnerabilities can provide important clues for predicting treatment response and for the development of novel strategies that prevent the emergence of therapy resistant tumors.     

Establishment of a reference library for evaluating computer ECG measurement programs

As a result of an international cooperative project entitled "Common Standards for Quantitative Electrocardiography" (CSE), an ECG reference data base has been established with the aim of standardizing computer-derived ECG measurements. The objective of the project is to reduce the wide variation in wave measurements currently obtained by ECG analysis programs. A library of 250 ECGs with selective ECG abnormalities was established and a comprehensive reviewing scheme was devised for the visual determination of the onsets and offsets of P, QRS, and T. This task was performed by a board of cardiologists on highly amplified, selected complexes from the library. A subset was examined in order to study beat-to-beat and intraobserver variability. By using a modified Delphi approach, individual outlying point estimates were eliminated in four successive rounds. In this way final referee estimates were obtained which proved to be highly reproducible and precise. A reference library has thereby been developed which allows testing of the performance of ECG measurement programs and is a useful instrument in establishing recommendations for more precise measurement rules and definitions.     

The OsMoSys approach to multi-formalism modeling of systems

Analysis and simulation of complex systems are facilitated by the availability of appropriate modeling formalisms and tools. In many cases, no single analysis and modeling method can successfully cope with all aspects of a complex system: a multi-formalism multi-solution approach is very appealing, since it offers the possibility of applying the most suitable formalisms and solution techniques to model and analyze different components or aspects of a system. Another important feature that a successfull modeling approach should include is the possibility of reusing (sub)models: by composing parameterized submodels and then instantiating the parameters, complete models of different scenarios can be obtained and analyzed.This paper introduces an innovative approach to multi-formalism modeling of systems that is part of the OsMoSys (Object-based multi-formaliSm MOdeling of SYStems) framework. OsMoSys uses the proposed modeling approach to build multi-formalism models, and workflow management to achieve multi-solution. Our modeling approach is based on meta-modeling, allowing to easily define and integrate different formalisms, and on some concepts from object orientation. Its main objectives are the interoperability of different formalisms and the definition of mechanisms to guarantee the flexibility and the scalability of the modeling framework.     

Elliptic Curve Cryptography Engineering

In recent years, elliptic curve cryptography (ECC) has gained widespread exposure and acceptance, and has already been included in many security standards. Engineering of ECC is a complex, interdisciplinary research field encompassing such fields as mathematics, computer science, and electrical engineering. In this paper, we survey ECC implementation issues as a prominent case study for the relatively new discipline of cryptographic engineering. In particular,we show that the requirements of efficiency and security considered at the implementation stage affect not only mere low-level, technological aspects but also, significantly, higher level choices, ranging from finite field arithmetic up to curve mathematics and protocols.     

MAGDA: A Mobile Agent based Grid Architecture

Mobile agents mean both a technology and a programming paradigm. They allow for a flexible approach which can alleviate a number of issues present in distributed and Grid-based systems, by means of features such as migration, cloning, messaging and other provided mechanisms. In this paper we describe an architecture (MAGDA – Mobile Agent based Grid Architecture) we have designed and we are currently developing to support programming and execution of mobile agent based application upon Grid systems.     

A model-driven approach for vulnerability evaluation of modern physical protection systems

Software and Systems Modeling - Modern physical protection systems integrate a number of security systems (including procedures, equipments, and personnel) into a single interface to ensure an...