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排序方式: 共有145条查询结果,搜索用时 78 毫秒
1.
Roycroft B. Lambkin P. Riesner S. Corbett B. Donegan J. F. 《Photonics Technology Letters, IEEE》2007,19(2):58-60
We have investigated a series of ridge waveguide lasers with deeply etched slots in the ridges. The slots do not penetrate the active region, but are deep enough to strongly perturb the longitudinal modes. By the addition of slots, a transition between perturbed-mode and coupled-cavity behavior is crossed. With a group of four or more slots, the below-threshold amplified spontaneous emission spectrum from each end of the laser has different periods and the facet-facet oscillations are suppressed indicating that the different sections have become quasi-independent. A model using a distributed emitter in the cavity reproduces this behavior. Above threshold, the single contact coupled cavity lasers are single mode with greater than 30-dB sidemode suppression ratio over a wide range of currents 相似文献
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Nikolai Gaponik Yury P. Rakovich Matthias Gerlach John F. Donegan Diana Savateeva Andrey L. Rogach 《Nanoscale research letters》2006,1(1):68-73
We have studied the photoluminescence and Raman spectra of a system consisting of a polystyrene latex microsphere coated by CdTe colloidal quantum dots. The cavity-induced enhancement of the Raman scattering allows the observation of Raman spectra from only a monolayer of CdTe quantum dots. Periodic structure with very narrow peaks in the photoluminescence spectra of a single microsphere was detected both in the Stokes and anti-Stokes spectral regions, arising from the coupling between the emission of quantum dots and spherical cavity modes. 相似文献
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Mick Donegan Jeffrey D. Morris Fulvio Corno Isabella Signorile Adriano Chió Valentina Pasian Alessandro Vignola Margret Buchholz Eva Holmqvist 《Universal Access in the Information Society》2009,8(4):259-275
Gaze-control enables people to control a computer by using eye-gaze to select items on screen. Gaze-control is a necessity
for people who have lost all motor control of their body and only have control over eye movements. In addition, gaze-control
can be the quickest and least tiring option for a far broader group of people with varying disabilities. This paper reports
findings from gaze-control user trials involving users from both groups: people who are totally paralyzed, as well as people
with a wide range of complex disabilities. The trials conducted involved four different centres supporting people with disabilities
in three different European countries. Several gaze-control systems were trialled by a large number of users with varying
needs and abilities. The perceived benefits of gaze-control are described, and recommendations for successful assessment and
implementation of gaze-control are provided. 相似文献
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McAleavey F.J. O'Gorman J. Donegan J.F. MacCraith B.D. Hegarty J. Maze G. 《IEEE journal of selected topics in quantum electronics》1997,3(4):1103-1111
Operation of an efficient continuous-wave (CW) thulium-doped fiber laser emitting at wavelength, λ=2.31 μm is reported. The fiber laser parameters are optimized with a view to ultimately producing a compact and efficient laser source for optical absorption based gas sensing. A number of fiber laser configurations are investigated to assess their suitability for narrow linewidth, tunable fiber laser operation emitting around λ=2.3 μm, which is a wavelength region of significant importance for hydrocarbon gas monitoring. Tuning ranges of 140 nm and linewidths of less than 210 MHz have been demonstrated with lasers with bulk external tuning grating. Preliminary hydrocarbon gas sensing investigation confirm the potential of this source for detection of ppb gas concentrations 相似文献
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Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity 下载免费PDF全文
Dr. Sudhir Landge Dr. Vasanthi Ramachandran Dr. Anupriya Kumar Dr. João Neres Kannan Murugan Dr. Claire Sadler Dr. Mick D. Fellows Vaishali Humnabadkar Dr. Prakash Vachaspati Dr. Anandkumar Raichurkar Sreevalli Sharma Sudha Ravishankar Supreeth Guptha Dr. Vasan K. Sambandamurthy Dr. Tanjore S. Balganesh Dr. Bheemarao G. Ugarkar Dr. V. Balasubramanian Dr. Balachandra S. Bandodkar Dr. Manoranjan Panda 《ChemMedChem》2016,11(3):331-339
Nitroarenes are less preferred in drug discovery due to their potential to be mutagenic. However, several nitroarenes were shown to be promising antitubercular agents with specific modes of action, namely, nitroimidazoles and benzothiazinones. The nitro group in these compounds is activated through different mechanisms, both enzymatic and non‐enzymatic, in mycobacteria prior to binding to the target of interest. From a whole‐cell screening program, we identified a novel lead nitrobenzothiazole (BT) series that acts by inhibition of decaprenylphosphoryl‐β‐d ‐ribose 2′‐epimerase (DprE1) of Mycobacterium tuberculosis (Mtb). The lead was found to be mutagenic to start with. Our efforts to mitigate mutagenicity resulted in the identification of 6‐methyl‐7‐nitro‐5‐(trifluoromethyl)‐1,3‐benzothiazoles (cBTs), a novel class of antitubercular agents that are non‐mutagenic and exhibit an improved safety profile. The methyl group ortho to the nitro group decreases the electron affinity of the series, and is hence responsible for the non‐mutagenic nature of these compounds. Additionally, the co‐crystal structure of cBT in complex with Mtb DprE1 established the mode of binding. This investigation led to a new non‐mutagenic antitubercular agent and demonstrates that the mutagenic nature of nitroarenes can be solved by modulation of stereoelectronic properties. 相似文献
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Brazilian city beaches are public spaces favoring citizens well-being. Urban studies relate built form and infrastructure with urban vitality and coastal studies underline uses as important for beach management, yet few researches relate form and infrastructure with beach uses. Understanding daily life as essential for public spaces and that spatial form relates with uses, this paper assesses time-based relationships between built and natural physical attributes and social life on the beaches of João Pessoa, a coastal city in North-east Brazil. Physical attributes are investigated at city scale - beach type, street network centrality and topography - and seafront scale - land uses, public/private interfaces, public infrastructure, beach sections and water quality. Beach social life was surveyed online, enquiring peoples' beach choice, visiting time and place, activities and evaluation. Infrastructure and street network follow topography and help configure shore and promenade for different landscapes. More central beaches have diverse land uses, well-equipped promenades and lighting and were popular night and day, while less central beaches had less infrastructure and were visited only by day. Findings highlight how physical attributes facilitate uses and, together with peoples’ evaluation, can inform urban beach design and planning. 相似文献
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