Deliberately Losing Control of C−H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism

Combined photochemical arylation, “nuisance effect” (S_NAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein–ligand structure determination. Reactions were deliberately allowed to run “out of control” in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with S_NAr processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.     

EV-DO Rev.A在日本风头渐旺将盖过HSDPA

2006年8月31日,NTT DoCoMo开始在日本东京的中心地带提供HSDPA服务,NEC为该服务提供了惟一的一款终端,支持最高可达3.6Mbit/s的数据下载,这一速度10倍于以前FOMA手机可支持的速度。NTT DoCoMo的用户使用HSDPA服务,不需要支付额外的费用。这一举措使原本已经非常激烈的日本三大移动运营商之间的竞争又步入了一个新阶段。KDDI对此做出回应,宣布将在今年12月份推出世界上第一个商用的EV-DO Rev.A服务,KDDI目前已经推出了两款支持该服务的终端。K DDI过去所取得的成功在很大程度上归功于其采用了CDMA,这使得KDDI有效地将…     

Predicting Forest Age Classes from High Spatial Resolution Remotely Sensed Imagery Using Voronoi Polygon Aggregation

Efficient identification of forest age is useful for forest management and ecological applications. Here we propose a user-assisted method for determining forest age using high spatial resolution remotely sensed imagery. This method requires individual trees to be extracted from imagery and represented as points. We use a local maximum filter to generate points that are converted to Voronoi polygons. Properties of the Voronoi polygons are correlated with forest age and used to aggregate points (trees) into areas (stands) based on three forest age classes. Accuracy of the aggregation ranges from approximately 68% to 78% and identification of the mature class is more consistent and accurate than the younger classes.     

Disciplinary and linguistic considerations for academic Web linking: An exploratory hyperlink mediated study with Mainland China and Taiwan

The Web has become an important means of academic information exchange and can be used to give new insights into patterns of informal scholarly communication. This study develops new methods to examine patterns of university Web linking, focusing on Mainland China and Taiwan, and including language considerations. Multiple exploratory investigations into Web links were conducted between universities in these two places. Firstly, inlinks were counted to each university Web site from its national peers using four alternative Web document models. The results were shown to correlate significantly with research productivity in Taiwan but not in the Mainland, although in the latter case less reliable institutional data could have been the cause. For Taiwan, this is the first evidence of a scholarly association with academic linking for a non-English speaking region. It was then ascertained that the same link counts associated more strongly with scientific than social scientific research productivity in Taiwan. This confirms the general assumption of greater Web use by the hard sciences. We then investigated Taiwan-Mainland university cross-links, and found that although English is extensively used on the Web, there was no evidence that it was the language of preference for informal scholarly communication between the two areas. This revised version was published online in August 2006 with corrections to the Cover Date.     

Epilepsy, retarded growth and onchocerciasis, in two areas of different endemicity of onchocerciasis in Burundi

A high prevalence of epilepsy (up to 1.3%) was observed in an area hyperendemic for onchocerciasis in the province of Bururi, Burundi. Following this observation, epileptics and controls were examined in 2 communes (administrative units) with different endemicity for onchocerciasis. Altogether, onchocerciasis was more frequent in epileptics (81.8%) than in controls from the same households (68.3%; P < 0.05). This difference was more marked in the hyperendemic area. Other possible causes of epilepsy, including cysticercosis, were infrequent (18 possible cases among 110 epileptics). During this survey, 9 epileptics with growth retardation were seen. They showed most characteristics of Nakalanga syndrome, which was described from Uganda. All 9 such cases were suffering from onchocerciasis. These findings give more evidence of a possible association between onchocerciasis and epilepsy, and between onchocerciasis and Nakalanga syndrome.     

智能功率控制产品的设计

构建和维护合适的功率环境对系统的正确运行非常关键。对功率的控制和管理越来越受到重视，无论是简单的手持式便携设备，还是多服务器机架系统，都希望能够节省能耗、降低成本。     

The ability of the Millon Clinical Multiaxial Inventory--Third Edition to detect malingering.

This study investigated the ability of the Millon Clinical Multiaxial Inventory--Third Edition (MCMI-III) to discriminate students malingering psychopathology (n=106) from bona fide psychiatric inpatients (n=202). Students were randomly assigned to a fake-bad or an honest-responding condition. Analyses investigated the ability of the modifier indices to discriminate fake-bad group participants from the psychiatric inpatients. Scale X raw cutoff score >178 yielded a positive predictive power (PPP) of 0.0, a negative predictive power (NPP) of 63.1, and a hit rate of 63.1%. Optimal cutoff scores were developed. Scale X Base Rate (BR) >84 provided a PPP of 55.6, an NPP of 72.1, and a hit rate of 65.2%. Scale Y BR