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排序方式: 共有96条查询结果,搜索用时 15 毫秒
1.
Biswas Uttara Rakshit Jayanta Kumar Das Joyashree Bharti Gaurav Kumar Suthar Bhuvneshwer Amphawan Angela Najjar Monia 《SILICON》2021,13(3):885-892
Silicon - In the present report, a photonic crystal based micro-ring resonator (MRR) structure is proposed which is very compact in size and has very fast response and is employed for temperature... 相似文献
2.
Sofia Gasperini Sabrine Bilel Veronica Cocchi Matteo Marti Monia Lenzi Patrizia Hrelia 《International journal of molecular sciences》2022,23(22)
Three fentanyl analogues Acrylfentanyl, Ocfentanyl and Furanylfentanyl are potent, rapid-acting synthetic analgesics that recently appeared on the illicit market of new psychoactive substances (NPS) under the class of new synthetic opioids (NSO). Pharmacotoxicological data on these three non-pharmaceutical fentanyl analogues are limited and studies on their genotoxicity are not yet available. Therefore, the aim of the present study was to investigate this property. The ability to induce structural and numerical chromosomal aberrations in human lymphoblastoid TK6 cells was evaluated by employing the flow cytometric protocol of the in vitro mammalian cell micronucleus test. Our study demonstrated the non-genotoxicity of Fentanyl, i.e., the pharmaceutical progenitor of the class, while its illicit non-pharmaceutical analogues were found to be genotoxic. In particular, Acrylfentanyl led to a statistically significant increase in the MNi frequency at the highest concentration tested (75 μM), while Ocfentanyl and Furanylfentnyl each did so at both concentrations tested (150, 200 μM and 25, 50 μM, respectively). The study ended by investigating reactive oxygen species (ROS) induction as a possible mechanism linked to the proved genotoxic effect. The results showed a non-statistically significant increase in ROS levels in the cultures treated with all molecules under study. Overall, the proved genotoxicity raises concern about the possibility of serious long-term consequences. 相似文献
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4.
Inflammation is the clinical expression of chemical mediators such as the pro-inflammatory cytokine tumor necrosis factor (TNF-)-alpha produced by macrophages and other cells activated in the immune response. Hence, agents that can inhibit TNF-alpha may be useful in treating arthritis and other diseases resulting from uncontrolled inflammation. We now report that the cleavage of heparin by the enzyme heparinase I generates sulfated disaccharide (DS) molecules that can inhibit the production of TNF-alpha. Administration of nanogram amounts of the sulfated DS molecules to experimental animals inhibited delayed-type hypersensitivity to a skin sensitizer and arrested the joint swelling of immunologically induced adjuvant arthritis. Notably, the sulfated DS molecules showed a bell-shaped dose-response curve in vitro and in vivo: decreased effects were seen using amounts of the DS molecules higher than optimal. Thus, molecular regulators of inflammation can be released from the natural molecule heparin by the action of an enzyme. 相似文献
5.
We investigated the cascading effects of chemical contaminants on alder leaf detritus quality and the exploitation of this feeding resource by benthic macroinvertebrates (isopods, gastropods, and mayfly nymphs). Trophic behavior and energetics of benthic macroinvertebrates were used to evaluate the effects of contaminants on detritus exploitation. A two-way factorial nested experimental design was used to statistically quantify how leaf detritus origin (polluted and unpolluted streams) and the pollution level of the site selected for microbial conditioning of the detritus could affect the feeding resource quality for aquatic benthic macroinvertebrates, as measured by their trophic behavior (i.e. food selection) and exploitation (i.e. food ingestion). Alder leaves collected from a polluted stream in a former mining area (South-Sardinia, Italy) had Cd, Pb, and Zn concentrations up to 10 times that of leaves collected from an unpolluted stream. When benthic macroinvertebrates were given the option to choose, they all selected leaves from the unpolluted stream and/or those conditioned in the unpolluted stream. Ingestion rates were also significantly affected by both considered factors: leaf origin and conditioning. In addition, synergistic effects strongly increased the chemical contaminant stress on the leaf detritus quality. These results show that the terrestrial component of land–water ecotones affected by mining can be a relevant indirect pathway of chemical stress to benthic macroinvertebrate species. 相似文献
6.
Ahmed Amine Rekik Florence Azaïs Norbert Dumas Frédérick Mailly Pascal Nouet 《Journal of Electronic Testing》2011,27(3):411-423
This paper presents a behavioral model that can be used to improve the manufacturability of systems based on MEMS convective
sensors. This model permits to handle faults related to process scattering, taking into account not only the electrical and
lateral geometrical parameters but also the influence of the cavity depth. Moreover correlations between conductive and convective
phenomena are included. The model is validated with respect to FEM simulations and a very good agreement is obtained between
the behavioral model and FEM results. The proposed model can then be used in system-level simulations, for instance to evaluate
the impact of process scattering on the performances of the sensing part and/or to investigate different design and calibration
strategies with respect to the system robustness. 相似文献
7.
This paper analyzes a Newsvendor type inventory model in which a manufacturer sells a single product to a retailer store whose
inventory is subject to errors stemming from execution problems. Hence, within the store, all of the products are not available
on shelf for sales either because the replenishment of the shelf from the backroom is subject to execution errors that mainly
result in products lost in the backroom or products misplaced on the other shelves of the store. We compare two situations:
in the first situation, the two supply chain actors are aware of errors and optimize their ordering decisions by taking into
account this issue. The second situation deals with the case where an advanced automatic identification system such as the
Radio Frequency Identification technology is deployed in order to eliminate errors. Each situation is developed for three
scenarios: in the centralized scenario, we consider a single decision-maker who is concerned with maximizing the entire supply
chain’s profit; in the decentralized uncoordinated scenario, the retailer and the manufacturer act as different parties and
do not cooperate. The third scenario is the decentralized coordinated scenario where we give conditions for coordinating the
channel by designing a buyback contract.
The authors would like to thank the editor, Prof. Dr. Hans-Otto Guenther, and two anonymous referees for their constructive
comments to improve this article. 相似文献
8.
9.
Cristina Siligardi Monica Montecchi Monia Montorsi Luca Pasquali 《Journal of the American Ceramic Society》2009,92(11):2784-2790
A lead-free frit containing high amount of copper and its glaze conceived for fine porcelain stoneware tiles were investigated. The glazes obtained under industrial firing were studied using X-ray photoelectron spectroscopy, X-ray diffraction, optical and scanning electron microscopy with energy dispersion spectroscopy. The mechanism of the red color formation on the surface was explained. The results indicated that the glaze presents a metallic gloss and iridescent colors on the surface, mainly associated to the formation of CuO crystallites and Cu metallic particles. Moreover, the Cu glaze showed a good chemical durability; this is particularly interesting because commercial Cu frits usually present poor chemical properties. 相似文献
10.
Genetic parameters of milk, fat, and protein yields were estimated in the first 3 lactations for registered Tunisian Holsteins. Data included 140,187; 97,404; and 62,221 test-day production records collected on 22,538; 15,257; and 9,722 first-, second-, and third-parity cows, respectively. Records were of cows calving from 1992 to 2004 in 96 herds. (Co)variance components were estimated by Bayesian methods and a 3-trait-3-lactation random regression model. Gibbs sampling was used to obtain posterior distributions. The model included herd × test date, age × season of calving × stage of lactation [classes of 25 days in milk (DIM)], production sector × stage of lactation (classes of 5 DIM) as fixed effects, and random regression coefficients for additive genetic, permanent environmental, and herd-year of calving effects, which were defined as modified constant, linear, and quadratic Legendre coefficients. Heritability estimates for 305-d milk, fat and protein yields were moderate (0.12 to 0.18) and in the same range of parameters estimated in management systems with low to medium production levels. Heritabilities of test-day milk and protein yields for selected DIM were higher in the middle than at the beginning or the end of lactation. Inversely, heritabilities of fat yield were high at the peripheries of lactation. Genetic correlations among 305-d yield traits ranged from 0.50 to 0.86. The largest genetic correlation was observed between the first and second lactation, potentially due to the limited expression of genetic potential of superior cows in later lactations. Results suggested a lack of adaptation under the local management and climatic conditions. Results should be useful to implement a BLUP evaluation for the Tunisian cow population; however, results also indicated that further research focused on data quality might be needed. 相似文献