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排序方式: 共有62条查询结果,搜索用时 15 毫秒
1.
Arwa Ishaq A. Khayyat Seema Zargar Tanveer A. Wani Muneeb U. Rehman Azmat Ali Khan 《International journal of molecular sciences》2022,23(10)
Atrazine (ATR) is a herbicide globally used to eliminate undesired weeds. Herbicide usage leads to various adverse effects on human health and the environment. The primary source of herbicides in humans is the food laced with the herbicides. The ATR binding to trypsin (TYP) was investigated in this study to explore its binding potential and toxicity. In vitro interaction of ATR with TYP was studied using multi-spectroscopic methods, molecular docking, and enzyme kinetics to explore the mechanism of binding for the TYP-ATR system. The TYP-ATR complex revealed binding constants (103 M−1), suggesting a moderate binding. The free energy for the TYP-ATR complexes was negative, suggesting a spontaneous interaction. Thermodynamic parameters enthalpy (ΔH) and entropy (ΔS) obtained positive values for the TYP-ATR system suggesting hydrophobic interactions in the binding process. Micro-environmental and conformational changes in TYP molecules were induced on interaction with ATR. Reduced catalytic activity of TYP was observed after interaction with ATR owing to the changes in the secondary structure of the TYP. 相似文献
2.
Phase Transformation of Metastable ZnSnO3 Upon Thermal Decomposition by In‐Situ Temperature‐Dependent Raman Spectroscopy 下载免费PDF全文
Tanujjal Bora Muna H. Al‐Hinai Ashraf T. Al‐Hinai Joydeep Dutta 《Journal of the American Ceramic Society》2015,98(12):4044-4049
Temperature‐dependent in‐situ Raman spectroscopy is used to investigate the phase transformation of zinc metastannate (ZnSnO3) to zinc orthostannate (Zn2SnO4) induced upon annealing in the ambient. ZnSnO3 microcubes (MCs) were synthesized at room temperature using a simple aqueous synthesis process, followed by characterization using electron microscopy, X‐ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and thermogravimetric analysis (TGA). Annealing of the ZnSnO3 MCs was carried out up to 1000°C, while recording the Raman spectra in‐situ at regular intervals. Phase transformation from metastannate to orthostannate was found to begin around 500°C with an activation energy of ~0.965 eV followed by the recrystallization into the inverse spinel orthostannate phase at ~750°C. Results from this study provide detailed understanding of the phase transformation behavior of perovskite ZnSnO3 to inverse spinel Zn2SnO4 upon thermal annealing. 相似文献
3.
Oleksandr Gryshkov Vitalii Mutsenko Dmytro Tarusin Diaa Khayyat Ortwin Naujok Ekaterina Riabchenko Yuliia Nemirovska Arseny Danilov Alexander Y. Petrenko Birgit Glasmacher 《International journal of molecular sciences》2021,22(6)
Alginate as a versatile naturally occurring biomaterial has found widespread use in the biomedical field due to its unique features such as biocompatibility and biodegradability. The ability of its semipermeable hydrogels to provide a favourable microenvironment for clinically relevant cells made alginate encapsulation a leading technology for immunoisolation, 3D culture, cryopreservation as well as cell and drug delivery. The aim of this work is the evaluation of structural properties and swelling behaviour of the core-shell capsules for the encapsulation of multipotent stromal cells (MSCs), their 3D culture and cryopreservation using slow freezing. The cells were encapsulated in core-shell capsules using coaxial electrospraying, cultured for 35 days and cryopreserved. Cell viability, metabolic activity and cell–cell interactions were analysed. Cryopreservation of MSCs-laden core-shell capsules was performed according to parameters pre-selected on cell-free capsules. The results suggest that core-shell capsules produced from the low viscosity high-G alginate are superior to high-M ones in terms of stability during in vitro culture, as well as to solid beads in terms of promoting formation of viable self-assembled cellular structures and maintenance of MSCs functionality on a long-term basis. The application of 0.3 M sucrose demonstrated a beneficial effect on the integrity of capsules and viability of formed 3D cell assemblies, as compared to 10% dimethyl sulfoxide (DMSO) alone. The proposed workflow from the preparation of core-shell capsules with self-assembled cellular structures to the cryopreservation appears to be a promising strategy for their off-the-shelf availability. 相似文献
4.
A significant challenge facing motor carriers and engineers in this nation is the limitation of vehicle size and weight based on pavement and bridge capacity. However, the current demands of society and industry occasionally require a truck to carry a load that exceeds the size and weight of the legal limit. In these cases, engineering analysis is required before a permit is issued to ensure the safety of the structures and roadways on the vehicle's route. A truck with a wheel gauge larger than the standard 1.83 m (6 ft) gauge requires additional engineering effort because the wheel load girder distribution factors (GDFs) established by AASHTO cannot be used to accurately estimate the live load in the girders. In this study, the finite-element method is used to develop modification factors for the AASHTO flexure and shear GDFs to account for oversized trucks. The results of the analysis showed that the use of the proposed modification factors with the specification-based GDFs can help increase the allowable loads on slab-on-girder bridges. 相似文献
5.
6.
Sarrafan Atabak Zareh Seiyed Hamid Khayyat Amir Ali Akbar Zabihollah Abolghassem 《Journal of Mechanical Science and Technology》2012,26(4):1179-1196
Magnetorheological (MR) damper is a prominent semi-active control device to vibrate mitigation of structures. Due to the inherent
non-linear nature of MR damper, an intelligent non-linear neuro-fuzzy control strategy is designed to control wave-induced
vibration of an offshore steel jacket platform equipped with MR dampers. In the proposed control system, a dynamic-feedback
neural network is adapted to model non-linear dynamic system, and the fuzzy logic controller is used to determine the control
forces of MR dampers. By use of two feedforward neural networks required voltages and actual MR damper forces are obtained,
in which the first neural network and the second one acts as the inverse dynamics model, and the forward dynamics model of
the MR dampers, respectively. The most important characteristic of the proposed intelligent control strategy is its inherent
robustness and its ability to handle the non-linear behavior of the system. Besides, no mathematical model needed to calculate
forces produced by MR dampers. According to linearized Morison equation, wave-induced forces are determined. The performance
of the proposed neuro-fuzzy control system is compared with that of a traditional semi-active control strategy, i.e., clipped
optimal control system with LQG-target controller, through computer simulations, while the uncontrolled system response is
used as the baseline. It is demonstrated that the design of proposed control system framework is more effective than that
of the clipped optimal control scheme with LQG-target controller to reduce the vibration of offshore structure. Furthermore,
the control strategy is very important for semi-active control. 相似文献
7.
Synthesis and Characterization of Glycol Chitosan DNA Nanoparticles for Retinal Gene Delivery 下载免费PDF全文
Dr. Rajendra N. Mitra Dr. Zongchao Han Miles Merwin Dr. Muhammed Al Taai Dr. Shannon M. Conley Dr. Muna I. Naash 《ChemMedChem》2014,9(1):189-196
Given the number of monogenic ocular diseases and the number of non‐monogenic degenerative ocular diseases for which gene therapy is considered as a treatment, the development of effective therapeutic delivery strategies for DNA is a critical research goal. In this work, nonviral nanoparticles (NPs) composed of glycol chitosan (GCS) and plasmid DNA (pDNA) were generated, characterized, and evaluated. These particles are stable, do not aggregate in saline, are resistant to DNases, and have a hydrodynamic diameter of approximately 250 nm. Furthermore, the plasmid in these NPs was shown to maintain its proper conformation and can be released and expressed inside the cell. To determine whether these NPs would be suitable for intraocular use, pDNA carrying the ubiquitously expressed CBA‐eGFP expression cassette was compacted and subretinally injected into adult wild‐type albino mice. At day 14 post‐injection (PI), substantial green fluorescent protein (GFP) expression was observed exclusively in the retinal pigment epithelium (RPE) in eyes treated with GCS NPs but not in those treated with uncompacted pDNA or vehicle (saline). No signs of gross retinal toxicity were observed, and at 30 days PI, there was no difference in electroretinogram function between GCS NP‐, pDNA‐, or vehicle‐treated eyes. These results suggest that with further development, GCS NPs could be a useful addition to the available repertoire of genetic therapies for the treatment of RPE‐associated diseases. 相似文献
8.
Mauro Giorcelli Patrizia Savi Mario Miscuglio Muna Hajj Yahya Alberto Tagliaferro 《Nanoscale research letters》2014,9(1):168
A wide-band microwave characterization of nanocomposites based on commercial multiwalled carbon nanotubes (MWCNTs) and epoxy resin is presented. The sample preparation method is discussed in detail. Field emission scanning electron microscopy is used for morphological sample analysis of nanocomposites and MWCNTs. The complex permittivity is measured in a wide frequency band (3 to 18 GHz) using a commercial dielectric probe (Agilent 85070D) and a network analyzer (E8361A). A statistical analysis based on one-way analysis of variance (ANOVA) technique is performed. The aim of this statistical analysis is to investigate the influence of concentration of nanoparticles inside the polymer matrix on the complex permittivity. This can be significantly different in nanocomposites even if the samples have similar electrical properties. 相似文献
9.
Tsai Chih-Ta Muna Yirga Belay Lin Hsueh-Yuan Kuo Cheng-Chien Hsiung Rainy 《Microsystem Technologies》2021,27(4):1267-1281
Microsystem Technologies - Universally, solar power microsystem for mini-grid is acceptable as a new approach to solve the global energy problem. Improving population lifestyle as well as the... 相似文献
10.
It was of interest to investigate the influence of both high doses of eicosapentaenoic acid (EPA) and low doses of 2-or 3-methylated
EPA on the antioxidant status, as they all cause hypolipidemia, but the dose required is quite different. We fed low doses
(250 mg/d/kg body wt) of different EPA derivatives or high doses (1500 mg/d/kg body wt) of EPA and DHA to rats for 5 and 7
d, respectively. The most potent hypolipidemic EPA derivative, 2,2-dimethyl-EPA, did not change the malondialdehyde content
in liver or plasma. Plasma vitamin E decreased only after supplementation of those EPA derivatives that caused the greatest
increase in the fatty acyl-CoA oxidase activity. Fatty acyl-CoA oxidase activity increased after administration of both EPA
and DHA at high doses. High doses of EPA and DHA decreased plasma vitamin E content, whereas only DHA elevated lipid peroxidation.
In liver, however, both EPA and DHA increased lipid peroxidation, but the hepatic level of vitamin E was unchanged. The glutathione-requiring
enzymes and the glutathione level were unaffected, and no significant changes in the activities of xanthine oxidase and superoxide
dismutase were observed in either low-or high-dose experiments. In conclusion, increased peroxisomal β-oxidation in combination
with high amounts of polyunsaturated fatty acids caused elevated lipid peroxidation. At low doses of polyunsaturated fatty
acids, lipid peroxidation was unchanged, in spite of increased peroxisomal β-oxidation, indicating that polyunsaturation is
the most important factor for lipid peroxidation. 相似文献