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排序方式: 共有1527条查询结果,搜索用时 15 毫秒
1.
Anna Stasiowicz Natalia Rosiak Ewa Tykarska Maciej Kozak Jacek Jenczyk Piotr Szulc Joanna Kobus-Cisowska Kornelia Lewandowska Anita Paziska Wojciech Paziski Judyta Cielecka-Piontek 《International journal of molecular sciences》2021,22(8)
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). 相似文献
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Stawarz Sylwester Witek Natalia Kucharczyk Wojciech Bakar Mohamed Stawarz Magdalena 《International Journal of Mechanics and Materials in Design》2019,15(3):585-599
International Journal of Mechanics and Materials in Design - The present work investigates the ablative and thermal properties of an epoxy resin which was modified with titanium dioxide... 相似文献
5.
Natalia Andronova 《Polymer》2005,46(18):6746-6755
The synthesis and characterization of degradable polymeric networks for biomedical applications was performed. Cross-linked films of poly(ε-caprolactone) (PCL) and poly(1,5-dioxepan-2-one) (PDXO) having various mole fractions of monomers and different cross-link densities were successfully prepared using 2,2′-bis-(ε-caprolactone-4-yl) propane (BCP) as cross-linking agent. Reaction parameters were carefully examined to optimise the film-forming conditions. Networks obtained were elastomeric materials, easy to cast and remove from the mould. Effect of CL content and cross-link density on the final properties of the polymer network was evaluated. High CL content or degree of cross-linking led to increase in Young's modulus and decrease in elongation at break. An increase in crystalline domains in films having a higher CL content was observed by optical microscopy. A greater thermal stability was observed in films having a high CL content. The hydrophilicity of the materials could be tailored by changing the CL content. The surface of the films became rougher with higher CL content. 相似文献
6.
A novel approach is presented to calculate the sensitivities of the scattering parameters of microwave filters obtained with the full‐wave mode‐matching (MM) technique. Using only the MM simulation of the original network, the sensitivities of the scattering parameters with respect to all designable parameters are obtained. The adjoint network method (ANM) is applied to the generalized scattering matrices of the different filter components. This guarantees good accuracy of the calculated sensitivities. The implementation details are discussed for N‐resonator ridge waveguide filters. Excellent agreement is obtained between the sensitivities calculated using ANM and those obtained using the expensive central differences. © 2006 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2006. 相似文献
7.
Our goal is to develop a robust out-of-core sorting program for a
distributed-memory cluster. The literature contains two dominant
paradigms for out-of-core sorting algorithms: merging-based and
partitioning-based. We explore a third paradigm, that of oblivious
algorithms. Unlike the two dominant paradigms, oblivious algorithms
do not depend on the input keys and therefore lead to predetermined
I/O and communication patterns in an out-of-core setting.
Predetermined I/O and communication patterns facilitate overlapping
I/O, communication, and computation for efficient implementation. We
have developed several out-of-core sorting programs using the paradigm
of oblivious algorithms. Our baseline implementation, 3-pass
columnsort, was based on Leighton's columnsort algorithm. Though
efficient in terms of I/O and communication, 3-pass columnsort has a
restriction on the maximum problem size. As our first effort toward
relaxing this restriction, we developed two implementations: subblock
columnsort and M-columnsort. Both of these implementations
incur substantial performance costs: subblock columnsort performs
additional disk I/O, and M-columnsort needs substantial
amounts of extra communication and computation. In this paper we
present slabpose columnsort, a new oblivious algorithm that we have
designed explicitly for the out-of-core setting. Slabpose columnsort
relaxes the problem-size restriction at no extra I/O or communication
cost. Experimental evidence on a Beowulf cluster shows that unlike
subblock columnsort and M-columnsort, slabpose columnsort runs
almost as fast as 3-pass columnsort. To the best of our knowledge,
our implementations are the first out-of-core multiprocessor sorting
algorithms that make no assumptions about the keys and produce output
that is perfectly load balanced and in the striped order assumed by
the Parallel Disk Model. 相似文献
8.
M. A. Chaudhry 《Journal of Materials Science》1991,26(4):1106-1108
The dielectric response of hexagonal boron nitride has been measured perpendicular to the cleavage planes at fixed temperatures in the range up to 914 K. The frequency span lies between 10 mHz and 10 kHz range. The dielectric response consists of two loss peaks and a strong low frequency dispersion (LFD). The results are related to the movement of impurity ions. 相似文献
9.
Abdul S Chaudhry 《Journal of the science of food and agriculture》2007,87(14):2617-2624
BACKGROUND: Two factorial studies compared enzymic and in sacco methods to estimate degradation of ruminant foods. Enzyme degradation (in vitro = enzyme) was determined from the release of leucine‐equivalent amino acid (LA) crude protein (CP) from sunflower meal (SF), maize gluten meal (MG), distillers' dark grain (DG) and field beans (FB) after their separate incubations with Streptomyces griseus enzyme for 0–24 h. In sacco crude protein (CP) degradation of these foods was estimated during washing (0 h) and rumen incubations in fistulated cows for 2–24 h. The LA data were expressed as g LA per either kg of CP (LACP) or acid‐hydrolysable LA (HLA) of each food and compared with in sacco data. RESULTS: These methods showed comparable degradation with time (P < 0.01). The in sacco and HLA were greater than LACP for all foods except MG where in sacco value was either lower or equal to LACP depending upon the incubation time (P > 0.05 or P < 0.05). Conversely, HLA was significantly (P < 0.01) greater than LACP from 2 h onwards. At 0 h, in sacco values were significantly greater than those of enzyme for SF, DG and FB (P < 0.05) but not for MG. The foods differed significantly for degradation constants (a, b, c) in each method (P < 0.05). CONCLUSIONS: Despite variations between in sacco and enzyme estimates for different foods, the relationships between these estimates suggest that the HLA enzyme method has the potential to estimate food degradation. Copyright © 2007 Society of Chemical Industry 相似文献
10.
Jaime Ortiz Óscar Palma Natalia González Santiago P. Aubourg 《European Journal of Lipid Science and Technology》2008,110(12):1127-1135
The flow ice system including ozone (OFI condition) was tested for slaughtering and storage (up to 16 days) of farmed rainbow trout (Oncorhynchus mykiss). Lipid damage analyses were carried out and compared to sensory acceptance and instrumental colour changes. Comparison to individuals processed with the flow ice system in the absence of ozone (FI condition) was undertaken. Rainbow trout slaughtered and chilled under FI and OFI conditions showed a low lipid damage development, according to lipid oxidation and hydrolysis events and lipid composition (polyunsaturated fatty acids, phospholipids and endogenous antioxidants) changes. Additionally, both icing conditions led to largely good quality and shelf life times and to the absence of changes in colour properties. It is concluded that flow ice as such, or including the presence of ozone, can be considered as ideal strategy to be employed as slaughtering and storage system during the commercialisation of the actual farmed species. The ozone presence has shown some profitable effects as leading to an extended shelf life time by quality retention of several sensory parameters; in contrast, some negligible negative effects could be observed on the secondary and tertiary lipid oxidation development. However, the oxidation values reached by individuals kept under OFI conditions cannot be considered as particularly high. 相似文献