Florence

In 1284 the Florence Commune started building the last set of walls that were to surround the city until the second half of the 19th century. In response to the strong demographic and economic expansion of the 13th century, the new walls would have to contain a space commensurate with the present and future grandeur of the Commune.¹ When completed in 1333, the walls circled the city for 8.5 kilometres and contained 73 towers, 15 doors and an area five times that included in the previous walls.     

Comparing orthogonal force and unidirectional strain component processing for tool condition monitoring

Signal processing using orthogonal cutting force components for tool condition monitoring has established itself in literature. In the application of single axis strain sensors however a linear combination of cutting force components has to be processed in order to monitor tool wear. This situation may arise when a single axis piezoelectric actuator is simultaneously used as an actuator and a sensor, e.g. its vibration control feedback signal exploited for monitoring purposes. The current paper therefore compares processing of a linear combination of cutting force components to the reference case of processing orthogonal components. Reconstruction of the dynamic force acting at the tool tip from signals obtained during measurements using a strain gauge instrumented tool holder in a turning process is described. An application of this dynamic force signal was simulated on a filter-model of that tool holder that would carry a self-sensing actuator. For comparison of the orthogonal and unidirectional force component tool wear monitoring strategies the same time-delay neural network structure has been applied. Wear-sensitive features are determined by wavelet packet analysis to provide information for tool wear estimation. The probability of a difference less than 5 percentage points between the flank wear estimation errors of above mentioned two processing strategies is at least 95 %. This suggests the viability of simultaneous monitoring and control by using a self-sensing actuator.     

Ribosome display of mammalian receptor domains

Many mammalian receptor domains, among them a large number of potential therapeutic target proteins, are highly aggregation-prone upon heterologous expression in bacteria. This severely limits functional studies of such receptor domains and also their engineering towards improved properties. One of these proteins is the Nogoreceptor, which plays a central role in mediating the inhibition of axon growth and functional recovery after injury of the adult mammalian central nervous system. We show here that the ligand binding domain of the Nogoreceptor folds to an active conformation in ternary ribosomal complexes, as formed in ribosome display. In these complexes the receptor is still connected, via a C-terminal tether, to the peptidyl tRNA in the ribosome and the mRNA also stays connected. The ribosome prevents aggregation of the protein, which aggregates as soon as the release from the ribosome is triggered. In contrast, no active receptor was observed in phage display, where aggregation appears to prevent incorporation of the protein into the phage coat. This strategy sets the stage for rapidly studying defined mutations of such aggregation-prone receptors in vitro and to improve their properties by in vitro evolution using the ribosome display technology.     

Statics Aware Grid Shells

We introduce a framework for the generation of polygonal gridshell architectural structures, whose topology is designed in order to excel in static performances. We start from the analysis of stress on the input surface and we use the resulting tensor field to induce an anisotropic nonEuclidean metric over it. This metric is derived by studying the relation between the stress tensor over a continuous shell and the optimal shape of polygons in a corresponding gridshell. Polygonal meshes with uniform density and isotropic cells under this metric exhibit variable density and anisotropy in Euclidean space, thus achieving a better distribution of the strain energy over their elements. Meshes are further optimized taking into account symmetry and regularity of cells to improve aesthetics. We experiment with quad meshes and hexdominant meshes, demonstrating that our gridshells achieve better static performances than stateoftheart gridshells.     

Reconstructing head models from photographs for individualized 3D‐audio processing

Visual fidelity and interactivity are the main goals in Computer Graphics research, but recently also audio is assuming an important role. Binaural rendering can provide extremely pleasing and realistic three‐dimensional sound, but to achieve best results it's necessary either to measure or to estimate individual Head Related Transfer Function (HRTF). This function is strictly related to the peculiar features of ears and face of the listener. Recent sound scattering simulation techniques can calculate HRTF starting from an accurate 3D model of a human head. Hence, the use of binaural rendering on large scale (i.e. video games, entertainment) could depend on the possibility to produce a sufficiently accurate 3D model of a human head, starting from the smallest possible input. In this paper we present a completely automatic system, which produces a 3D model of a head starting from simple input data (five photos and some key‐points indicated by user). The geometry is generated by extracting information from images and accordingly deforming a 3D dummy to reproduce user head features. The system proves to be fast, automatic, robust and reliable: geometric validation and preliminary assessments show that it can be accurate enough for HRTF calculation.     

Understanding dengue fever dynamics: a study of seasonality in vector-borne disease models

Dengue fever dynamics show seasonality, with the disease transmission being higher during the warmer seasons. In this paper, we analyse seasonally forced epidemic models with and without vector dynamics. We assume small seasonal effects and obtain approximations for the real response of each state variable and also for the corresponding amplitude and phase via decomposition of the sinusoidal forcing into imaginary exponential functions. The analysis begins with the simplest susceptible-infected-susceptible (SIS) model, followed by the simplest model with vector dynamics, susceptible-infected-susceptible for hosts and uninfected-vector (SISUV). Finally, we compare the more complex susceptible-infected-recovered (SIR) and susceptible-infected-recovered for hosts and uninfected-vector (SIRUV) models and conclude that the models give basically the same information when we replace, in the SIR model, the human infectivity by a function of both human and mosquito infectivities.     

Analysis of gap times in a two-stage stochastic flowshop with overlapping operations

The impact of transfer batching (also referred to as lot splitting) on the performance of flowshops has received widespread attention in the literature. Most papers have emphasized the usefulness of lot splitting in cutting down average flow times, as it enables the overlapping of operations at different stages of the flowshop. However, while most analytical papers have studied deterministic flowshops, an important downside of lot splitting has been overlooked; i.e., the occurrence of idle time between the processing of consecutive sublots belonging to the same process batch (referred to as gap times). Gap times add no value to the product; they merely increase the process batch makespan at the different stages. In deterministic systems, these gap times may be avoided by balancing the processing rates of the different machines in the shop; in stochastic settings, however, they may occur even when the system is perfectly balanced, due to the inherent variability in the setup and processing times. Studying a two-stage flowshop with a single product type, this paper provides insight into the behavior of the gap times, and develops an approximation for the process batch makespan at the second stage in terms of the system characteristics and the lot splitting policy.