Risk for Separation Anxiety Disorder Among Girls: Paternal Absence, Socioeconomic Disadvantage, and Genetic Vulnerability.

The authors examined genetic and environmental influences, including the contributions of 2 measured aspects of the shared environment of twins (paternal absence, socioeconomic disadvantage) on the development of mother-reported separation anxiety disorder (SAD) history in a sample of 1,887 female twin pairs. Four different symptom categories of SAD were considered. Results revealed that all 4 SAD symptom categories were significantly heritable, whereas the contribution of shared environmental influences to the variation in risk was significant for only 2 of the 4 SAD categories. Paternal absence was found to have an important influence in vulnerability for SAD, whereas the effect of socioeconomic disadvantage was less robust. Evidence for race differences in the etiology of SAD was not found. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Potential for carrying dyes derived from spalting fungi in natural oils

Wood colored internally by fungi has long been used by woodcrafters and artisans as a substitute for synthetic dyes. Recent advances in the field of spalted wood have led to methods by which the fungal dyes can be extracted from either a fungal solution or colonized wood and then reapplied to clear wood. This takes the “guess work” out of spalting, as well as the time necessary for fungal colonization; however, it requires organic solvents like dichloromethane, which are toxic and not readily available to consumers. Herein, the authors show that the dyes can be successfully carried and blended together (to increase the range of colors) in a range of natural oils. The blue–green dye of Chlorociboria species, called xylindein, carried best in raw linseed oil, the red dye of Scytalidium cuboideum performed best in Danish oil, although more dye could be carried in raw linseed oil, and the yellow dye of Scytalidium ganodermophthorum performed best in walnut oil. The ability to carry and mix these dyes in easily purchased, nontoxic oils opens up their use to woodworkers who seek to follow the traditions of spalted wood, but do not have the skills or time to work with live fungal cultures or fungal dyes suspended in toxic organic solvents.     

Lingering misinterpretations in garden-path sentences: Evidence from a paraphrasing task.

Using a forced-choice question-answering paradigm, K. Christianson, A. Hollingworth, J. F. Halliwell, and F. Ferreira (2001) showed that the original misinterpretation built during the analysis of a garden-path sentence lingers even after reanalysis has occurred. However, their methodology has been questioned (R. P. G. van Gompel, M. J. Pickering, J. Pearson, & G. Jacob, 2006). In this study, the authors report evidence for lingering misinterpretations using a paraphrasing methodology, which is less biased than previous methodologies. Using paraphrasing, they found that garden-path sentences are paraphrased according to a partially reanalyzed interpretation. This finding suggests that the arguments put forward by Christianson et al. are correct: Comprehenders' final interpretations of sentences are often incorrect and do not correspond to the initial input. These findings support the theory that comprehension can occur in a "good-enough" manner (F. Ferreira, V. Ferraro, & K. G. D. Bailey, 2002; F. Ferreira & N. Patson, 2007). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The subjective effects of alcohol–tobacco co-use: An ecological momentary assessment investigation.

Alcohol and tobacco use covary at multiple levels of analysis, and co-use of the 2 substances may have profound health consequences. To characterize the motivationally relevant processes contributing to co-use, the current study used ecological momentary assessment (EMA) to examine the subjective consequences of naturally occurring simultaneous use of alcohol and tobacco. Current smokers who reported frequently drinking alcohol (N = 259) used electronic diaries to monitor their daily experiences for 21 days. Participants responded to prompted assessments and also initiated recordings when they smoked a cigarette or completed the first drink in a drinking episode. Momentary reports of smoking and alcohol consumption were associated with one another, and these effects remained after adjustment for occasion- and person-level covariates. When participants consumed alcohol, they reported increased pleasure and decreased punishment from the last cigarette. Smoking was associated with small increases in pleasure from the last drink. Ratings of buzzed and dizzy were synergistically affected by co-use of alcohol and tobacco. Co-use was also followed by higher levels of craving for both alcohol and tobacco. Results point to the importance of reward and incentive processes in ongoing drug use and suggest that alcohol intensifies real-time reports of the motivational consequences of smoking more strongly than smoking affects corresponding appraisals of alcohol effects. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The effects of familial risk, personality, and expectancies on alcohol use and abuse.

This study tested a structural model of the association between familial risk, personality risk, alcohol expectancies, and alcohol abuse in a sample of 224 young adult offspring of alcoholics and 209 offspring of nonalcoholics. The results provided support for 2 personality-risk pathways, a social deviance proneness and an excitement/pleasure seeking path, that accounted for a significant portion of the association between a familial alcoholism and alcohol abuse. The path from familial alcoholism to social deviance proneness lead directly to alcohol problems. The path from familial alcoholism to excitement/ pleasure seeking was associated with increased drinking, which, in turn, was associated with alcohol problems. Positive alcohol expectancies accounted for part of the association between excitement seeking and alcohol use. The results suggest 2 different biopsychosocial mechanisms that elevate risk for abuse in the offspring of alcoholics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Potential for fungal dyes as colorants in oil and acrylic paints

Potential applications for colorants derived from the spalting fungi Chlorociboria aeruginascens, Chlorociboria aeruginosa, Scytalidium cuboideum, and Scytalidium ganodermophthorum are of growing interest across a variety of fields, from wood and textile dyes, to solar cells. Previous research found that these dyes could be carried in natural oils, specifically raw linseed oil, instead of organic solvents, thereby eliminating the toxicity issues surrounding such carriers. In this work, dyes from the aforementioned fungi were extracted, carried in raw linseed oil, and mixed with a range of oil and acrylic paints to determine if the oil carrier was appropriate for delivering the dyes into a paint matrix. The oil-based dyes did not mix evenly with the acrylic paints; however, the acrylic paints maintained the color of the dyes. In contrast, the oil-based paints mixed well with the dyes, but the dyes decolorized (completely lost color) due to the presence of refined linseed oil in the paint base. Artists’ paints do not appear to be compatible with fungal dyes when carried in oil; however, there are still many potential applications for the oil-based dyes, such as wood and textile dyeing.     

A new method to efficiently induce a site-specific double-strand break in the fission yeast Schizosaccharomyces pombe

Double‐strand DNA breaks are a serious threat to cellular viability and yeast systems have proved invaluable in helping to understand how these potentially toxic lesions are sensed and repaired. An important method to study the processing of DNA breaks in the budding yeast Saccharomyces cerevisiae is to introduce a unique double‐strand break into the genome by regulating the expression of the site‐specific HO endonuclease with a galactose inducible promoter. Variations of the HO site‐specific DSB assay have been adapted to many organisms, but the methodology has seen only limited use in the fission yeast Schizosaccharomyces pombe because of the lack of a promoter capable of inducing endonuclease expression on a relatively short time scale (~1 h). We have overcome this limitation by developing a new assay in which expression of the homing endonuclease I‐PpoI is tightly regulated with a tetracycline‐inducible promoter. We show that induction of the I‐PpoI endonuclease produces rapid cutting of a defined cleavage site (> 80% after 1 h), efficient cell cycle arrest and significant accumulation of the checkpoint protein Crb2 at break‐adjacent regions in a manner that is analogous to published findings with DSBs produced by an acute exposure to ionizing irradiation. This assay provides an important new tool for the fission yeast community and, because many aspects of mammalian chromatin organization have been well‐conserved in Sz. pombe but not in S. cerevisiae, also offers an attractive system to decipher the role of chromatin structure in modulating the repair of double‐stranded DNA breaks. Copyright © 2012 John Wiley & Sons, Ltd.     

Timeline follow-back versus global self-reports of tobacco smoking: A comparison of findings with nondaily smokers.

Methods assessing nondaily smoking are of concern because biochemical measures cannot verify self-reports beyond 7 days. This study compared 2 self-reported smoking measures for nondaily smokers. A total of 389 college students (48% women, 96% White, mean age = 19 years) smoking between 1 and 29 days out of the past 30 completed computer assessments in 3 cohorts, with the order of administration of the measures counterbalanced. Values from the 2 measures were highly correlated. Comparisons of timeline follow-back (TLFB) with the global questions for the total sample of nondaily smokers yielded statistically significant differences (p     

pocrm: An R-package for Phase I trials of combinations of agents

This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; 0005 and 0010) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.     

Evidence for distributivity effects in comprehension.

In the current article, we introduce a new methodology for detecting whether a word in a sentence is conceptually represented as plural and use it to shed light on a debate about whether comprehenders interpret singular indefinite noun phrases within a distributed predicate as plural during online reading. Experiment 1 extended a methodology previously used by Berent, Pinker, Tzelgov, Bibi, and Goldfarb (2005) to test individual words or word pairs by having readers judge, at a critical word, whether 1 or 2 words appeared on a computer screen while performing self-paced reading on a sentence presented in 1- and 2-word chunks. In line with Berent et al., Experiment 1 indicated that participants were slower to judge that 1 word was on the screen when the word was plural (e.g., cats) than when it was singular (e.g., cat). Experiment 2 used this paradigm to show that readers build different conceptual representations for distributed versus collective predicates and interpret a singular indefinite noun phrase within a distributed predicate as plural (e.g., Kaup, Kelter, & Habel, 2002; but cf. Filik, Paterson, & Liversedge, 2004; Paterson, Filik, & Liversedge, 2008). (PsycINFO Database Record (c) 2010 APA, all rights reserved)