Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution

The Delta Sxrb interval of the mouse Y chromosome is critical for spermatogenesis and expression of the male-specific minor transplantation antigen H-Y. Several genes have been mapped to this interval and each has a homologue on the X chromosome. Four, Zfy1 , Zfy2 , Ube1y and Dffry , are expressed specifically in the testis and their X homologues are not transcribed from the inactive X chromosome. A further two, Smcy and Uty , are ubiquitously expressed and their X homologues escape X-inactivation. Here we report the identification of another gene from this region of the mouse Y chromosome. It encodes the highly conserved eukaryotic translation initiation factor eIF-2gamma. In the mouse this gene is ubiquitously expressed, has an X chromosome homologue which maps close to Dmd and escapes X-inactivation. The coding regions of the X and Y genes show 86% nucleotide identity and encode putative products with 98% amino acid identity. In humans, the eIF-2gamma structural gene is located on the X chromosome at Xp21 and this also escapes X-inactivation. However, there is no evidence of a Y copy of this gene in humans. We have identified autosomal retroposons of eIF-2gamma in both humans and mice and an additional retroposon on the X chromosome in some mouse strains. Ark blot analysis of eutherian and metatherian genomic DNA indicates that X-Y homologues are present in all species tested except simian primates and kangaroo and that retroposons are common to a wide range of mammals. These results shed light on the evolution of X-Y homologous genes.     

Truth,trust, and civic duty: Cultural factors in citizens' perceptions of mobile phone apps and social media in disasters

This study investigates how citizens perceive the role of mobile phone apps specifically designed for disaster communication, and how these perceptions may differ from perceived roles and functions of social media in disaster‐related tasks/situations. Focusing on trust in authorities and technology use, results suggest that social media use not only fosters trust via shared narratives and collective sense‐making but may also improve trust relationships through local authorities assuming the function of a trustworthy information provider. In disaster apps usage, trust between citizens and authorities is generated through perceptions of shared responsibility rather than shared narratives. Apps were seen as mechanisms that reveal authorities' general willingness to share control, which may help overcome citizens' perceptions that they are distrusted by authorities.     

Perceptual processes in matching and recognition of complex pictures.

The role of perceptual feature sampling in speeded matching and recognition was explored in 4 experiments. Experiments 1-3 involved a perceptual matching task with pictures of various objects and scenes. In Experiments 2 and 3, same-different judgments were given under time pressure. The main objective of the matching task was to obtain measures of the perceptual processing rates of different object features. Experiment 4 was an old-new recognition experiment, in which the same stimuli as those in the matching task were used. Response signals were used to limit processing time in the recognition task. The results demonstrated that it is possible to predict speeded recognition performance from performance in perceptual matching. A simple stochastic feature-sampling model provides a unified account of the data from the 4 experiments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A feature-sampling account of the time course of old–new recognition judgments.

This article describes the feature-sampling theory of recognition (FESTHER), a new model of the time course of recognition judgments based on a model of the time course of perceptual processing in categorization (K. Lamberts, 1995, 1998). FESTHER is applied to previous results and to data from 4 old–new recognition experiments. Experiments 1 and 2 provided a preliminary test of the model's ability to explain recognition judgments of simple objects under response deadlines. Experiments 3 and 4 involved a response-signal procedure to elicit recognition judgments at different time lags after presentation of a stimulus. Simple objects and words were used as stimuli in Experiments 3 and 4, respectively. The new model accounts well for the data from the 4 experiments and offers a parsimonious account of the time course of recognition judgments based on the time-dependent availability of stimulus information. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Feature-sampling and random-walk models of individual-stimulus recognition.

Traditional process models of old-new recognition have not addressed differences in accuracy and response time between individual stimuli. Two new process models of recognition are presented and applied to response time and accuracy data from 3 old-new recognition experiments. The 1st model is derived from a feature-sampling account of the time course of categorization, whereas the 2nd model is a generalization of a random-walk model of categorization. In the experiments, a new technique was used, which yielded reliable individual-stimulus data through repeated presentation of structurally equivalent items. The results from the experiments showed reliable differences in accuracy and response times between stimuli. The random-walk model provided the better account of the results from the 3 experiments. The implications of the results for process models of recognition are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus

A physical map encompassing approximately 2.0 megabases (Mb) in the region of the mouse X-inactivation center has been constructed. The map extends from the Gjb-1 locus to the Xist locus and demonstrates the order of probes inseparable by genetic analysis. The deduced locus order is as follows: Gjb-1, Ccg-1, DXCrc171, Rps4, Phka, DXCrc177, DXCrc318, Xist. Detailed physical mapping in the region between the Phka and Xist loci indicates the position of CpG-rich islands associated with the 5' end of genes. The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region.