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排序方式: 共有337条查询结果,搜索用时 15 毫秒
1.
Rajendra K. Bordia Brian J. Daigleish Panos G. Charalambides Anthony G. Evans 《Journal of the American Ceramic Society》1991,74(11):2776-2780
Results of four-point bend tests on notched beams of a laminated unidirectional fiber-reinforced glass matrix composite are presented. The failure sequence has been established through in situ examination. The dominant damage mode is a mixed-mode, split crack that runs parallel to the predominant fiber directions. The crack interacts with and crosses over imperfectly aligned fibers. The resulting bridging tractions are sufficient to cause the critical strain energy release rate to increase substantially as the crack extends. Several other damage modes are also observed. These include mode I (tensile) matrix cracks bridged by fibers, mode II (shear) cracks, and compressive damage at the loading points. 相似文献
2.
Electric and magnetic field measurements around overhead and underground power lines have been performed extensively within a transmission and distribution electric grid. Measurements have been performed at different heights of the human body close to such transmission and distribution power lines that operate at a frequency of 50 Hz, at different currents and at three different voltages of 11, 66 and 132 kV. These measurements were performed in an attempt to firstly verify that the existing measurements fall within the signified guidelines for electric and magnetic field exposure, published in 1998 by the International Commission on Non-Ionizing Radiation Protection. Furthermore, and most importantly, were used to validate/develop a model capable of predicting the magnetic field produced in both overhead and underground transmission and distribution power lines using experimental measurements. This is achieved by establishing a linear correlation between the current load of one of the two three phase circuits and the magnetic field, in an attempt to predict the magnetic fields produced in power lines using the SCADA system at overloaded periods. 相似文献
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4.
Aigli G. Vakrakou Anastasia Alexaki Maria-Evgenia Brinia Maria Anagnostouli Leonidas Stefanis Panos Stathopoulos 《International journal of molecular sciences》2022,23(15)
This article recapitulates the evidence on the role of mammalian targets of rapamycin (mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect with mTOR signaling cascades include autophagy, inflammasome activation, innate (e.g., microglial) and adaptive (B and T cell) immune responses, and axonal and neuronal toxicity/degeneration. There is robust evidence that mTOR inhibitors, such as rapamycin, ameliorate the clinical course of the animal model of MS, experimental autoimmune encephalomyelitis (EAE). New, evolving data unravel mechanisms underlying the therapeutic effect on EAE, which include balance among T-effector and T-regulatory cells, and mTOR effects on myeloid cell function, polarization, and antigen presentation, with relevance to MS pathogenesis. Radiologic and preliminary clinical data from a phase 2 randomized, controlled trial of temsirolimus (a rapamycin analogue) in MS show moderate efficacy, with significant adverse effects. Large clinical trials of indirect mTOR inhibitors (metformin) in MS are lacking; however, a smaller prospective, non-randomized study shows some potentially promising radiological results in combination with ex vivo beneficial effects on immune cells that might warrant further investigation. Importantly, the study of mTOR pathway contributions to autoimmune inflammatory demyelination and multiple sclerosis illustrates the difficulties in the clinical application of animal model results. Nevertheless, it is not inconceivable that targeting metabolism in the future with cell-selective mTOR inhibitors (compared to the broad inhibitors tried to date) could be developed to improve efficacy and reduce side effects. 相似文献
5.
Fernando C. Gomes Cludio N. Meneses Panos M. Pardalos Gerardo Valdisio R. Viana 《Computers & Operations Research》2006,33(12):3520
Several approximation algorithms with proven performance guarantees have been proposed to find approximate solutions to classical combinatorial optimization problems. However, theoretical results may not reflect the experimental performance of the proposed algorithms. As a consequence, a question arises: how “far” from the theoretically proved performance are the experimental results? We conduct a controlled empirical study of approximation algorithms for the Vertex Cover and the Set Covering Problems. Many authors have proposed approximation algorithms for those problems. Our main goal is to better understand their strengths, weaknesses, and operation. Although we implement more than one algorithm to find feasible solutions to either problems, this work does not emphasize competition between them. The quality of the solutions related to the theoretical performance guarantees are analyzed instead. The computational experiments showed that the proven performance guarantees of all tested algorithms did not forecast well the empirical performance. 相似文献
6.
The Effective Fracture Toughness in Hydraulic Fracturing 总被引:1,自引:0,他引:1
Panos Papanastasiou 《International Journal of Fracture》1999,96(2):127-147
This paper examines the effective fracture toughness approach which is used in hydraulic fracturing in order to explain the
high net-pressures that are often observed in field operations. The effective fracture toughness is calculated using a fully
deterministic elasto-plastic hydraulic fracturing model. Rock is modelled by Mohr–Coulomb flow theory of plasticity for cohesive-frictional
dilatant material. Fluid flow is modelled by lubrication theory. A cohesive crack model which takes into account the softening
behaviour of rocks is employed as the propagation criterion. The fully coupled model is solved numerically by the finite element
method and the effective fracture toughness is calculated using the path independent J-integral. The results show that plastic
yielding near the tip of a propagating fracture provides an effective shielding, resulting in an increase in the rock effective
fracture toughness by more than an order of magnitude. It is demonstrated that an elastic model based on the concept of effective
fracture toughness matches the results of plasticity quite well. The effective fracture toughness increases with formation
yielding, which is influenced by the deviator of the in-situ stresses, the rock strength, the elastic modulus and the pumping
parameters. Tables of effective fracture toughness for a representative set of physical parameters are presented.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
7.
Missing data imputation is an important research topic in data mining. The impact of noise is seldom considered in previous
works while real-world data often contain much noise. In this paper, we systematically investigate the impact of noise on
imputation methods and propose a new imputation approach by introducing the mechanism of Group Method of Data Handling (GMDH)
to deal with incomplete data with noise. The performance of four commonly used imputation methods is compared with ours, called
RIBG (robust imputation based on GMDH), on nine benchmark datasets. The experimental result demonstrates that noise has a
great impact on the effectiveness of imputation techniques and our method RIBG is more robust to noise than the other four
imputation methods used as benchmark. 相似文献
8.
Extract-transform-load (ETL) workflows model the population of enterprise data warehouses with information gathered from a large variety of heterogeneous data sources. ETL workflows are complex design structures that run under strict performance requirements and their optimization is crucial for satisfying business objectives. In this paper, we deal with the problem of scheduling the execution of ETL activities (a.k.a. transformations, tasks, operations), with the goal of minimizing ETL execution time and allocated memory. We investigate the effects of four scheduling policies on different flow structures and configurations and experimentally show that the use of different scheduling policies may improve ETL performance in terms of memory consumption and execution time. First, we examine a simple, fair scheduling policy. Then, we study the pros and cons of two other policies: the first opts for emptying the largest input queue of the flow and the second for activating the operation (a.k.a. activity) with the maximum tuple consumption rate. Finally, we examine a fourth policy that combines the advantages of the latter two in synergy with flow parallelization. 相似文献
9.
10.
A variety of peer-to-peer (P2P) systems for sharing digital information are currently available and most of them perform searching by exact key matching. In this paper we focus on similarity searching and describe FuzzyPeer, a generic broadcast-based P2P system which supports a wide range of fuzzy queries. As a case study we present an image retrieval application implemented on top of FuzzyPeer. Users provide sample images whose sets of features are propagated through the peers. The answer consists of the top-k most similar images within the query horizon. In our system the participation of peers is ad hoc and dynamic, their functionality is symmetric and there is no centralized index. 相似文献