Pulsed laser deposition of silicon nitride thin films by laser ablation of a Si target in low pressure ammonia

We report the deposition of Si-N films by multipulse excimer laser ( = 308 nm, _FWHM = 30 ns) ablation of Si wafers placed in a slow flow of NH₃ in the pressure range (1 bar-1 mbar). The films are deposited on to a Si collector placed parallel to the Si target. We succeeded in depositing pure amorphous Si₃N₄ films at a pressure of 1 mbar of NH₃. The deposition rate reached a maximum value of 0.2–0.3 nm per pulse. At lower pressures, the deposited films consist of a fine mixture of three amorphous phases (amorphous stoichiometric silicon nitride, amorphous non-stoichiometric silicon nitride and amorphous silicon). The amorphous silicon is prevalent in films deposited at a pressure of several to several tens of bars. Droplets of polycrystalline -Si are sometimes visible on the film surface. The experimental evidence, is analysed with a view to elucidating the participation in the chemical synthesis of the three main stages of the process: the substance expulsion from the target by laser ablation, the transition through the gas of the expulsed substance and it's final impact on the collector. We conclude that silicon nitride is mostly synthesized during the impact on the collector of the flow of the ablated substance.     

Gain measurements in the KrCl excimer laser

The single-pass/double-pass amplified spontaneous emission technique has been used to measure the net gain at 222.4 nm in a discharge-pumped UV-preionized KrCl laser. The net gain has been measured as a function of pump rate and total pressure in He- and Ne-based gas mixtures. A maximum net gain of 0.15 cm(-1) has been obtained in a 0.09% HC1/10.1% Kr/1.5% He/88.3% Ne mixture at a total pressure of 355 kPa and at a specific power loading of approximately 21 MW/cc. The data presented are compared with previous net gain measurements performed using the passive absorption cell method.     

The magnitude of a product recall: offshore outsourcing vs. captive offshoring effects

The escalation in product recalls in recent years is attributed to the rise of globalisation and associated challenges of offshoring. Extant SCM research suggests that product recalls have a significant negative impact on financial performance, but gaps exist relative to the managerial actions to minimise their impact. Recall response strategies have become more important in the press, given that a single recall may result in the mandatory withdrawal of millions of products from the market, with firms incurring enormous logistics costs and brand damage. In this study, we address this gap in the research, and using a measure of product recall defined as the volume of products withdrawn from the market due to product quality failure. We explore the scale of the recall in the context of pharmaceutical sector global sourcing strategies, exploring whether the variation in global sourcing decisions not only increases the likelihood of a recall, but also influences the capability to minimise the total cost of recall. Our results suggest that offshore outsourcing and captive offshoring have opposite effects in terms of their influence on the magnitude of product recall. We summarise the implications through a compelling set of insights for future global sourcing strategy research themes.     

Nitrogen fixation and productivity of winter annual legume cover crops in Upper Midwest organic cropping systems

Nutrient Cycling in Agroecosystems - Legume cover crops can play a valuable role in maintaining and increasing soil quality and nitrogen availability, but are infrequently grown in the Upper...     

Shortening of Free-running XeCl Laser Pulses by Stimulated Brillouin Scattering

Abstract

A stimulated Brillouin scattering mirror has been used to ‘temporally tune’ from nanoseconds to subnanoseconds the width of laser pulses generated by a free running XeCl oscillator, equipped with a super-Gaussian reflectivity unstable resonator. Pulse shortening techniques by stimulated Brillouin scattering (SBS) and by truncated SBS have been investigated. A maximum pulse shortening of about fifty has been achieved by truncated SBS.     

Copper Transfer from Cu–Aβ to Human Serum Albumin Inhibits Aggregation,Radical Production and Reduces Aβ Toxicity

Amyloid‐β peptides (Aβ) and the protein human serum albumin (HSA) interact in vivo. They are both localised in the blood plasma and in the cerebrospinal fluid. Among other functions, HSA is involved in the transport of the essential metal copper. Complexes between Aβ and copper ions have been proposed to be an aberrant interaction implicated in the development of Alzheimer's disease, where Cu is involved in Aβ aggregation and production of reactive oxygen species (ROS). In the present work, we studied copper‐exchange reaction between Aβ and HSA or the tetrapeptide DAHK (N‐terminal Cu‐binding domain of HSA) and the consequence of this exchange on Aβ‐induced ROS production and cell toxicity. The following results were obtained: 1) HSA and DAHK removed Cu^II from Aβ rapidly and stoichiometrically, 2) HSA and DAHK were able to decrease Cu‐induced aggregation of Aβ, 3) HSA and DAHK suppressed the catalytic HO^. production in vitro and ROS production in neuroblastoma cells generated by Cu–Aβ and ascorbate, 4) HSA and DAHK were able to rescue these cells from the toxicity of Cu–Aβ with ascorbate, 5) DAHK was more potent in ROS suppression and restoration of neuroblastoma cell viability than HSA, in correlation with an easier reduction of Cu^II–HSA than Cu–DAHK by ascorbate, in vitro. Our data suggest that HSA is able to decrease aberrant Cu^II–Aβ interaction. The repercussion of the competition between HSA and Aβ to bind Cu in the blood and brain and its relation to Alzheimer's disease are discussed.     

Numerical Studies on the Seismic Retrofit of Bridges Using Shape Memory Alloys

Recent earthquakes have highlighted the seismic vulnerability of bridges due to excessive movements at the joints (in simply supported deck bridges) or concentration of seismic forces in a few piers (in multi-span continuous deck bridges). Steel-based seismic restrainers and viscous shock transmitters are used to limit the joint openings in simply supported deck bridges or to redistribute the seismic force among all piers in continuous deck bridges, respectively. Currently used devices, however, have some limitations such as large dimensions, no energy dissipation, possible large residual displacements, bad control of the force transmitted to the substructure (steel restrainers), large dimensions, difficulty of installation in existing structures, need of maintenance, and sensitivity to the earthquake characteristics (viscous shock transmitters). Shape memory alloys (SMAs) with superelastic behavior show the potential to overcome the limitations involved in the current technologies. In this article, a multi-performance seismic device based on superelastic SMA wires is proposed for the seismic retrofit of multi-span simply supported and continuous deck bridges. The effectiveness of the SMA devices is assessed through a number of nonlinear time-history analyses on two bridge structures representative of existing Italian highway bridges. Results are compared to the seismic response of the bridges in the as-built configuration.     

Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae

Glutathione (GSH) is an abundant and ubiquitous low-molecular-weight thiol which has proposed roles in many cellular processes including protection against the deleterious effects of reactive oxygen species. Our experiments have addressed the role of GSH in protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae, and have shown that GSH and catalase provide overlapping defense systems. GSH appears to be the primary antioxidant for protection against hydrogen peroxide since mutants lacking GSH (gsh1) or glutathione reductase (glr1) are sensitive, whereas, strains lacking catalase A (cta1) or catalase T (ctt1) are unaffected in resistance to this oxidant. Furthermore, following treatment with hydrogen peroxide, the levels of oxidized, protein-bound and extracellular GSH were all increased at the expense of intracellular GSH. However, there are two lines of evidence that indicate catalases are required in the absence of GSH; firstly, strains that lack both catalase A and T accumulate increased levels of oxidized glutathione following treatment with hydrogen peroxide; and secondly, deletion of catalase genes exacerbates the hydrogen peroxide sensitivity of glr1 and gsh1 mutants.