Agentsheets: a medium for creating domain-oriented visual languages

Customized visual representations enable end users to achieve their programming goals. Here, designers work with users to tailor visual programming languages to specific problem domains. We describe a design methodology and a tool for creating domain oriented, end user programming languages that effectively use visualization. We first describe a collaborative design methodology involving end users and designers. We then present Agentsheets, a tool for creating domain oriented visual programming languages, and illustrate how it supports collaborative design by examining experiences from a real language design project. Finally, we summarize the contributions of our approach and discuss its viability in industrial design projects     

Using components for rapid distributed software development

Software development has not reached the maturity of other engineering disciplines; it is still challenging to produce software that works reliably, is easy to use and maintain, and arrives within budget and on time. In addition, relatively small software systems for highly specific applications are in increasing demand. This need requires a significantly different approach to software development from that used by their large, monolithic, general-purpose software counterparts such as Microsoft Word. The paper discusses the use of components for rapid distributed software development. It reports on the the experience of a large testbed called Educational Software Components of Tomorrow (www.escot.org), supported by the US National Science Foundation     

AgentCubes: Incremental 3D end-user development

3D game development can be an enticing way to attract K-12 students to computer science, but designing and programming 3D games is far from trivial. Students need to achieve a certain level of 3D fluency in modeling, animation, and programming to be able to create compelling 3D content. The combination of innovative end-user development tools and standards-based curriculum that promotes IT fluency by shifting the pedagogical focus from programming to design, can address motivational aspects without sacrificing principled educational goals. The AgentCubes 3D game-authoring environment raises the ceiling of end-user development without raising the threshold. Our formal user study shows that with Incremental 3D, the gradual approach to transition from 2D to 3D authoring, middle school students can build sophisticated 3D games including 3D models, animations, and programming.     

Mr. Vetro: A Collective Simulation for teaching health science

Why has technology become prevalent in science education without fundamentally improving test scores or student attitudes? We claim that the core of the problem is how technology is being used. Technologies such as simulations are currently not used to their full potential. For instance, physiology simulations often follow textbooks by sequentially exposing individual systems such as the circulatory and respiratory systems one at a time, leaving out essential comprehension of system interactions. Moreover, the standard computer lab hides students behind large monitors and ignores the social aspect of learning. We have created a new kind of infrastructure, called Collective Simulations to provide engaging inquiry-based science learning modules that uniquely combine social learning pedagogies with distributed simulation technology. This infrastructure creates immersive learning experiences based on wirelessly connected computers and enables radically different classroom learning experiences that engage students and teachers simultaneously. Collective Simulations allow students to learn about the intricacies of interdependent complex systems by engaging in discourse with other students and teachers. As part of our Mr. Vetro Collective Simulation, students learn about physiology through technology-enhanced role-play. Each group controls physiological variables of a single organ on their computer. A central simulation gathers all the data and projects the composite view of a human. In an example activity, the heart and lung teams collaborate to adjust parameters and reach homeostasis. Results from formal evaluation studies demonstrate a positive impact on scientific inquiry, student learning, and students’ interest in personal health issues. This article describes Mr. Vetro and its underlying architecture and presents the evaluation results.     

Comparative analysis of promoter regions containing binding sites of the heterodimeric transcription factor Ino2/Ino4 involved in yeast phospholipid biosynthesis

The inositol/choline responsive element (ICRE) functions as a UAS element mediating coordinate expression of structural genes required for yeast phospholipid biosynthesis. However, ICRE motifs could be detected upstream of various genes apparently not involved in lipid metabolism. In this work we investigated the expression pattern of selected genes containing ICRE promoter motifs, as identified by in silico analysis (ARG4, ERG20, FAR8, GPD2, RSF1, URA8, VHT1 and YEL073C). It turned out that the presence of an ICRE upstream of a gene of unknown function indeed allows to conclude for regulation by phospholipid precursors, which is mediated by activators Ino2/Ino4 and the repressor Opi1. We also demonstrated in vitro binding of Ino2/Ino4 heterodimers to promoter regions. Thus, our analysis supports the view that identification of regulatory elements by a database search provides evidence for a specific pattern of gene expression. Activation by pathway-specific regulators may suggest a physiological function for as yet uncharacterized genes.