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Manana Kandashvili Georgi Gamkrelidze Lia Tsverava Tamar Lordkipanidze Eka Lepsveridze Vincenzo Lagani Maia Burjanadze Manana Dashniani Merab Kokaia Revaz Solomonia 《International journal of molecular sciences》2022,23(3)
Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a subject of intensive research. Currently, there are no clinically approved drugs that can act as preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties of a compound–myo-inositol (MI) and the present research broadens previous results and demonstrates the long-term disease-modifying effect of this drug, as well as the amelioration of cognitive comorbidities. For the first time, we show that long-term treatment with MI: (i) decreases the frequency and duration of electrographic SRS in the hippocampus; (ii) has an ameliorating effect on spatial learning and memory deficit associated with epileptogenesis, and (iii) attenuates cell loss in the hippocampus. MI treatment also alters the expression of the glial fibrillary acidic protein, LRRC8A subunit of volume-regulated anion channels, and protein tyrosine phosphatase receptor type R, all expected to counteract the epileptogenesis. All these effects are still present even 4 weeks after MI treatment ceased. This suggests that MI may exert multiple actions on various epileptogenesis-associated changes in the brain and, therefore, could be considered as a candidate target for prevention of epileptogenesis. 相似文献
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A. Mirmefstein A. junod E. Walker B. Revaz J. Y. Genoud G. Triscone 《Journal of Superconductivity and Novel Magnetism》1997,10(5):527-535
In order to document the behavior of the mean-field mixed-state specific heat of an isotropic. strongly type-II superconductor
(i.e., with a large value of the Ginzburg parameterk), and to provide a basis for comparison with high-temperature superconductors, we measured the specific heatC of the alloy Nb0.77Zr0.23 withT
c
= 10.8K, B
c2 (0) = 7.9T, in magnetic fieldsB = 0, 0.2, 1.0, 12, 2.0, 2.4. 3.0, 3.3. 4.0. 4.4, 4.8, 5.2, 6.0. 6.6, 7.2 and 10 T. The values of the upper critical fieldB
c2
( T), thermodynamic critical fieldB
c
(T), Ginzburg parameterk(T), and coefficient γ(B) = limT0(C(T. B)/T)
are derived from the specific heat data and found to be in agreement with the GLAG theory in the dirty limit. The behavior
of the mixed-state specific heat is analyzed in terms ofC
el
/T,∂(C
el
/T)/∂B, and∂(C
el
/T)/∂T vs. Tcurves, whereC
el
is the electronic contribution to the specific heat. 相似文献
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A. Podlesnyak A. Mirmelstein V. Bobrovskii E. Mitberg B. Goshchitskii T. D'yachkova E. Khlybov B. Revaz A. Junod J.-Y. Genoud 《Journal of Superconductivity and Novel Magnetism》2000,13(1):145-152
A series of infinite-layer compounds Nd x Sr1?x CuO2 were synthesized by high-pressure technique under different pressure, temperature, and time conditions. Crystal structure, microstructure, and superconducting properties of the samples obtained were systematically investigated as a function of the synthesis conditions. The stability of the IL phase was studied using annealing procedures in Ar- and O2-flow, as well as under oxygen pressure up to 90 bar followed by thermogravimetric, energy-dispersive X-ray analysis, and X-ray diffraction measurements. On the basis of the results obtained we suggest a decomposition mechanism for the infinite-layer phase, which is responsible for the degradation of T c , as well as a routine to produce electron-doped infinite-layer compounds with a sharp diamagnetic signal of bulk superconductivity. 相似文献
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A. Podlesnyak A. Mirmelstein V. Bobrovskii E. Mitberg B. Goshchitskii T. D''yachkova E. Khlybov B. Revaz A. Junod J.-Y. Genoud 《Journal of Superconductivity》2000,13(1):145-152
A series of infinite-layer compounds Nd
x
Sr1–x
CuO2 were synthesized by high-pressure technique under different pressure, temperature, and time conditions. Crystal structure, microstructure, and superconducting properties of the samples obtained were systematically investigated as a function of the synthesis conditions. The stability of the IL phase was studied using annealing procedures in Ar- and O2-flow, as well as under oxygen pressure up to 90 bar followed by thermogravimetric, energy-dispersive X-ray analysis, and X-ray diffraction measurements. On the basis of the results obtained we suggest a decomposition mechanism for the infinite-layer phase, which is responsible for the degradation of T
c
, as well as a routine to produce electron-doped infinite-layer compounds with a sharp diamagnetic signal of bulk superconductivity. 相似文献
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Ch. Renner B. Revaz J. -Y. Genoud Ø. Fischer 《Journal of Low Temperature Physics》1996,105(5-6):1083-1089
We present local probe tunneling spectroscopy of Bi2Sr2CaCu2O8+ single crystals for different oxygen concentrations, from optimally doped (Tc=92.2 K) to highly overdoped (Tc=56.0 K) phases. With increasing oxygen overdoping, the superconducting gap (p) is reduced and the dip structure beyond p at negative sample bias1 shifts toward the Fermi energy. Apart from the shift in energy of these features, the generic shape of the tunneling spectra remains unchanged. The gap roughly scales with Tc, and 2p/kBTc stays large even in the highly overdoped phase. We also present preliminary results on the temperature dependence of the tunneling spectra. They are consistent with a gap that is largely independent on temperature up to the vicinity of Tc 相似文献
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