A novel hybrid artificial intelligent approach based on neural fuzzy inference model and particle swarm optimization for horizontal displacement modeling of hydropower dam

Horizontal displacement of hydropower dams is a typical nonlinear time-varying behavior that is difficult to forecast with high accuracy. This paper proposes a novel hybrid artificial intelligent approach, namely swarm optimized neural fuzzy inference system (SONFIS), for modeling and forecasting of the horizontal displacement of hydropower dams. In the proposed model, neural fuzzy inference system is used to create a regression model whereas Particle swarm optimization is employed to search the best parameters for the model. In this work, time series monitoring data (horizontal displacement, air temperature, upstream reservoir water level, and dam aging) measured for 11 years (1999–2010) of the Hoa Binh hydropower dam were selected as a case study. The data were then split into a ratio of 70:30 for developing and validating the hybrid model. The performance of the resulting model was assessed using RMSE, MAE, and R ². Experimental results show that the proposed SONFIS model performed well on both the training and validation datasets. The results were then compared with those derived from current state-of-the-art benchmark methods using the same data, such as support vector regression, multilayer perceptron neural networks, Gaussian processes, and Random forests. In addition, results from a Different evolution-based neural fuzzy model are included. Since the performance of the SONFIS model outperforms these benchmark models with the monitoring data at hand, the proposed model, therefore, is a promising tool for modeling horizontal displacement of hydropower dams.

     

Growth hormone increases and IGF-1 reduces the response to Escherichia coli infusion in injured pigs

OBJECTIVE: To investigate if growth hormone (GH) or its main mediator insulin-like growth factor-1 (IGF-1) alters the response to infusion of live Escherichia coli in injured pigs. DESIGN: Controlled experiment. SETTING: University laboratory, Norway. SUBJECTS: 30 piglets. INTERVENTIONS: The response to infusion of Escherichia coli was compared after a bolus of GH 16 IU (n = 8) or a continuous infusion of IGF-1 1.3 mg/hour (n = 8) in injured piglets. A group with trauma (surgery) and Escherichia coli infusion (n = 8) and a group with trauma only (n = 6) served as controls. MAIN OUTCOME MEASURES: Systemic and regional haemodynamics, oxygen consumption, and acid-base regulation; and circulating concentrations of catecholamines, free fatty acids (FFA), glucose, and lactate Results: After infusion of Escherichia coli, cardiac output was lower and heart rate was higher in the GH than in the IGF-1-treated group. Aortic pH was lower in the GH group compared with the septic controls, whereas aortic pH was higher in the IGF-1 group compared with the septic controls. Portal vein pH was lower in the GH group than in the other three groups. Free fatty acids and lactate concentrations were higher in the GH group than in the other three groups. Glucose concentrations were lower in the IGF-1 group than in the other three groups. Renal artery flow was higher in the IGF-1 than in the GH group and the septic controls. Circulating concentrations of dopamine was higher in the IGF-1 group than in the other three groups, whereas that of noradrenaline was higher in the GH group than in the IGF-1 group. (For all differences stated, p < 0.05). CONCLUSIONS: Acute treatment with GH increased the circulatory and metabolic response to Escherichia coli infusion, in contrast to treatment with IGF-1, which reduced the response     

Growth hormone and surgery

Growth hormone (GH) is a very potent anabolic agent released in the physiological situation in a pulsative manner from the pituitary gland. GH stimulates the protein synthesis and increases the intracellular transport of amino acids. When GH is administered to surgical patients, nitrogen retention is regularly seen, and in most situations fast mobilization takes place. The present data indicate that GH has a beneficial effect on the healing processes after surgery and trauma.     

Treatment of hypersecretory ileostomy, gastrostomy and fistula of the small intestine with the somatostatin analog octreotide

Hypersecretory stomas or fistulas are disabling conditions for the patients and a therapeutic challenge to the surgeons. Octreotide treatment is reported to reduce stoma output and the need for intravenous supplements. Octreotide treatment also reduces social disability due to postprandial hypersecretion causing frequent changes of stoma systems. Two patients with high output stomas and one patient with high output ileocutaneous fistula were treated with the somatostatin analogue octreotide. Reductions in stoma or fistula output from 48 to 62% were observed.     

Growth hormone and insulinlike growth factor 1 promote intestinal uptake and hepatic release of glutamine in sepsis

The aim of the present study was to establish whether the steroids, progesterone, androstenedione, testosterone and oestradiol, were present in the mesonephric-gonadal complex of female and male sheep fetuses around sexual differentiation (that is, from day 28 to day 45 of gestation, with sexual differentiation occurring at approximately day 32). A second aim was to test whether the mesonephric-gonadal complex, mesonephros (days 35-45 only) and gonad (days 35-45 only) were capable of steroid synthesis in vitro. The steroid contents in the mesonephric-gonadal complex were not detectable before sexual differentiation. However, from day 35 of gestation onwards, the mesonephric-ovarian complex contained mainly oestradiol and the mesonephric-testicular complex contained mainly testosterone: from day 35 until day 45 the increase in content of these two steroids exceeded the increase in the mass of tissue by more than fivefold. From day 40 to day 45 of gestation, the contents of the other steroids in the pathways to oestradiol increased progressively in both sexes but more in parallel with the increase in tissue mass. In contrast to the steroid contents in the tissue at recovery, the mesonephric-gonadal tissue from both sexes in tissue culture was able to synthesize most steroids before and after sexual differentiation and also to metabolise supplementary androstenedione to oestradiol. These findings suggest that many, if not all, of the steroidogenic enzymes in the pathway from cholesterol to oestradiol are present before sexual differentiation. Most of the aforementioned steroids were present in detectable amounts in isolated mesonephros and gonad of both sexes after sexual differentiation. Moreover, for both the isolated mesonephros and gonad, there were increases in the mean contents of most steroids after culture relative to the contents in the tissues at recovery. These data suggest that the mesonephros, as well as the gonad, in both sexes is capable of synthesizing steroid. It is concluded that, in the sheep fetus, the female and male gonads are steroidogenically active after sexual differentiation, that the steroidogenic enzymes develop before sexual differentiation, and that the mesonephros is a site of steroid synthesis.