Potential of the Stromal Matricellular Protein Periostin as a Biomarker to Improve Risk Assessment in Prostate Cancer

Prostate cancer (PCa) ranges from indolent to aggressive tumors that may rapidly progress and metastasize. The switch to aggressive PCa is fostered by reactive stroma infiltrating tumor foci. Therefore, reactive stroma-based biomarkers may potentially improve the early detection of aggressive PCa, ameliorating disease classification. Gene expression profiles of PCa reactive fibroblasts highlighted the up-regulation of genes related to stroma deposition, including periostin and sparc. Here, the potential of periostin as a stromal biomarker has been investigated on PCa prostatectomies by immunohistochemistry. Moreover, circulating levels of periostin and sparc have been assessed in a low-risk PCa patient cohort enrolled in active surveillance (AS) by ELISA. We found that periostin is mainly expressed in the peritumoral stroma of prostatectomies, and its stromal expression correlates with PCa grade and aggressive disease features, such as the cribriform growth. Moreover, stromal periostin staining is associated with a shorter biochemical recurrence-free survival of PCa patients. Interestingly, the integration of periostin and sparc circulating levels into a model based on standard clinico-pathological variables improves its performance in predicting disease reclassification of AS patients. In this study, we provide the first evidence that circulating molecular biomarkers of PCa stroma may refine risk assessment and predict the reclassification of AS patients.     

Design and implementation of a new scheduler for enhancing multi-rate fairness in IEEE 802.16

Without the definition of a mandatory scheduling algorithm for channel resource assignment, WiMAX is open to Quality of Service (QoS) enhancements by research groups and developers, at the aim of managing heterogeneous flows with different QoS requirements. Furthermore, besides performance enhancement, another key issue arises for QoS delivery: it is known as multi-rate fairness and it deals with efficient resource allocation for providing sufficient bandwidth to high rate flows, without penalizing low rate ones. In this paper, uplink scheduling algorithms are studied and an innovative solution is proposed to achieve performance enhancement, multi-rate fairness and improved QoS management. After an overview of the state of the art, two scheduling algorithms based on Deficit Round Robin are studied, implemented and tested in NS2 simulator. The schedulers are validated and compared through exhaustive simulations, showing the benefits coming from the adoption of the proposed scheduling mechanism.     

Noncoherent iterative decoding of spectrally efficient coded modulations

In this paper, we consider possible solutions for noncoherent decoding of concatenated codes with spectrally efficient modulations. Two main classes of schemes are considered. A first class is obtained by concatenating parallel coding schemes with differential encoding. A second class considers serially concatenated coding structures and possible schemes derived from turbo trellis coded modulation (t-tcm), which do not employ differential encoding. In the first case, at the receiver side we consider separate detection and decoding, while in the second case we consider joint detection and decoding. The major problem connected with such an iterative decoding procedure is that taking into account an augmented channel memory leads to an intolerable trellis size, and hence to an impractical decoding complexity. Reduced-complexity techniques suited to iterative decoding become fundamental, and we consider a recently proposed state-reduction technique. This way, the performance of a coherent receiver is approached, by keeping the number of receiver states fixed.     

脂肪酶解聚壳聚糖及其衍生物的研究

壳聚糖及其衍生物能很容易被脂肪酶解聚。当壳聚糖乳酸盐溶液与脂肪酶在２５℃下作用１０ｍｉｎ后，其溶液粘度被降低到初始值的３５％，分子量从约７００ｋＤａ减少到１３ｋＤａ（还原糖滴定法测定）。脂肪酶浓度在４．５×１０－３～９×１０－１ｇ／Ｌ范围内，解聚初速度与酶浓度成对数线性关系。Ｎ－羧甲基壳聚糖比壳聚糖更容易被脂肪酶解聚。     

State‐of‐the‐Art Neutral Tint Multichromophoric Polymers for High‐Contrast See‐Through Electrochromic Devices

Two new multichromophoric electrochromic polymers featuring a conjugated EDOT/ProDOT copolymer backbone (PXDOT) and a reversible Weitz‐type redox active small molecule electrochrome (WTE) tethered to the conjugated chain are reported here. The careful design of the WTEs provides a highly reversible redox behavior with a colorless red switching that complements the colorless blue switching of the conjugated backbone. Subtractive color mixing successfully provides high performing solution processable polymeric layers with colorless neutral tint switchable limiting states for application in see‐through electrochromic devices. Design, synthesis, comprehensive chemical and spectroelectrochemical characterization as well as the preparation of a proof‐of‐concept device are discussed.     

The influence of hydrogen and nitrogen on the formation of Si nanoclusters embedded in sub-stoichiometric silicon oxide layers

This work reports the study concerning the influence of the preparation conditions on the structure of silicon rich oxide (SRO) deposited by PECVD method by which the structural properties of the film are strictly related. In particular we investigated the role of reactant gases N₂O and SiH₄ on the total Si concentration, Si excess concentration, Si clustered concentration and size of nanoclusters formed by high annealing temperature. We payed particular attention on the role of the hydrogen and nitrogen during the Si agglomeration.The presence of hydrogen atoms on the as-deposited specimen, confirmed by the Si–H bonds peak on the FTIR analysis, has been directly correlated to the silicon excess concentration in the layer. The silicon, oxygen and nitrogen atomic density has been calculated from RBS analysis. These information were coupled to the ones obtained using methodology based on electron energy loss spectroscopy combined with energy filtered images, which allowed us to quantify the clustered silicon concentration in annealed sub-stoichiometric silicon oxide layers (SiO_x). We have verified that the nitrogen dissolved in the layer inhibits the Si excess clustering so that the efficiency of silicon agglomeration process decreases as the nitrogen content increases.