Anti-BlUFf: towards counterfeit mitigation in IC supply chains using blockchain and PUF

International Journal of Information Security - The complexity of today’s integrated circuit (IC) supply chain, organised in several tiers and including many companies located in different...     

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

Neurodegenerative disorders are primarily characterized by neuron loss. The most common neurodegenerative disorders include Alzheimer’s and Parkinson’s disease. Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms. This lack of pathogenesis-targeting therapies is primarily due to the restrictive effects of the blood–brain barrier (BBB), which keeps close to 99% of all “foreign substances” out of the brain. Since their discovery, nanoparticles have been successfully used for targeted delivery into many organs, including the brain. This review briefly describes the pathophysiology of Alzheimer’s, Parkinson’s disease, and amyotrophic lateral sclerosis, and their current management approaches. We then highlight the major challenges of brain-drug delivery, followed by the role of nanotherapeutics for the diagnosis and treatment of various neurological disorders.     

LCD电视:让世界感知它们的存在

在当前全球电视市场发展中,消费者的喜好成为推动市场的主导力量,新兴的电视技术正在改变着全球电视市场。首先,大屏幕电视价格下降,消费者购买能力的提升,使35英寸以上的电视逐步成为市场的焦点。其次,很多用户开始考虑购买第二台电视,安装在浴室,卧室中等,轻薄的平板电视开始走入家庭。再次,年轻的消费者已经淘汰了CRT,液晶电视成为他们的首选。这些消费趋势都有利于平板电视市场的发展。     

Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders

An aptamer is a short sequence of synthetic oligonucleotides which bind to their cognate target, specifically while maintaining similar or higher sensitivity compared to an antibody. The in-vitro selection of an aptamer, applying a conjoining approach of chemistry and molecular biology, is referred as Systematic Evolution of Ligands by Exponential enrichment (SELEX). These initial products of SELEX are further modified chemically in an attempt to make them stable in biofluid, avoiding nuclease digestion and renal clearance. While the modification is incorporated, enough care should be taken to maintain its sensitivity and specificity. These modifications and several improvisations have widened the window frame of aptamer applications that are currently not only restricted to in-vitro systems, but have also been used in molecular imaging for disease pathology and treatment. In the food industry, it has been used as sensor for detection of different diseases and fungal infections. In this review, we have discussed a brief history of its journey, along with applications where its role as a therapeutic plus diagnostic (theranostic) tool has been demonstrated. We have also highlighted the potential aptamer-mediated strategies for molecular targeting of COVID-19. Finally, the review focused on its future prospective in immunotherapy, as well as in identification of novel biomarkers in stem cells and also in single cell proteomics (scProteomics) to study intra or inter-tumor heterogeneity at the protein level. Small size, chemical synthesis, low batch variation, cost effectiveness, long shelf life and low immunogenicity provide advantages to the aptamer over the antibody. These physical and chemical properties of aptamers render them as a strong biomedical tool for theranostic purposes over the existing ones. The significance of aptamers in human health was the key finding of this review.     

东南亚正在成为下一个液晶电视热市场 单位出货量未来5年将增长7倍

据iSuppli公司报告,在价格下降、用户对液晶电视的了解增强,本地区经济充满活力和消费者日益富裕等因素的综合推动下,2007年-2012年东南亚液晶电视出货量将增长7倍以上.     

松下继续主宰等离子平板电视市场

平板电视市场前3强占总体市场份额的83%。据iSuppli称,在松下品牌的力量支持下,该公司在2006年第4季度继续在等离子显示器平板电视(PDP)生产领域保持领先地位,占这一市场中出货量的37.3%。与此同时,受广泛韩国市场液晶显示器(LCD)平板电     

A low-cost and efficient cloud monitoring camera system design for imaging satellites

Design and development of a cloud monitoring camera (CMC) as a secondary camera for imaging/remote-sensing satellites is proposed here. It is well known that presence of clouds alters the earth-atmospheree energy budget by scattering and absorbing the shortwave radiation and absorbing and re-emitting the infrared radiation. Detection of clouds at precise positions, prior to the initiation of the imaging session of the primary (super resolution) camera can aid in saving power as well as memory storage of the satellite. Key feature of the proposed system is the implementation of an onboard cloud detection system in the visible band. The proposed system is miniature in size and cost-effective when compared to the existing integrated visible and infrared band detection system. It primarily consists of lens assembly, detector head assembly, field programmable gate array (FPGA)-based camera electronics system with supporting proximity electronics. Cloud detection algorithm for the visible band images is derived and simulated with the help of Laboratory Virtual Instrument Engineering Workbench software. The verification and hardware realization of the algorithm is achieved by implementing it on a FPGA-based system. Overall simulated and measured efficiency of more than 94% was achieved. The volume of the system is 85 mm × 85 mm × 25 mm and weighs approximately 2 kg, making it suitable for satellite mounting.     

High power millimeter-wave TE03 to TM11 mode converters

Transmission of power from 42 ± 0.2 GHz gyrotron (TE₀₃ mode) to tokamak or dummy load requires a set of transmission line components. It includes a set of mode converters that converts circularly unpolarised TE₀₃ mode to polarised HE₁₁ mode. The mode conversion sequence is methodised in two steps; first from TE₀₃ to TE₀₁ mode and then from TE₀₁ to TM₁₁ mode. The proposed mode converters performance depends on the parameters such as waveguide radius, beat wavelength, number of ripples, its perturbation amplitude (η) and bending angle. These parameters are numerically optimised and verified in CST microwave studio. TE₀₃ to TE₀₁ mode conversion is realised by the generation of intermediate mode TE₀₂. The mode conversion length for TE₀₃ to TE₀₂ mode converter is6λ₀, (where λ_b is the beat wavelength of corresponding mode conversion) which converts 99.15% of an incident circular TE₀₃ mode power into TE₀₂ mode power. Next, mode converter converts TE₀₂ mode into TE₀₁ mode with 99.06% efficiency along the optimal length of6λ_b. For TE₀₁ to TM₁₁ mode conversion, two conversion methodologies have been proposed: first using axis arc bend (34.94°) technique to convert TE₀₁ into its analogous degenerate mode with 99.01% conversion efficiency and second using parabolic curve with 90° bend, which gives a conversion efficiency of 97.5%.