Near infrared light-induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol

Light-sensitive drug delivery systems are considered ideal for applications in the biomedical fields for their ability to release the payload in an on-demand spatiotemporal controlled manner through the manipulation of the light source. Among the broad radiation spectrum, near infrared (NIR) light is considered advantageous compared to UV and visible light, due to its inherently lower photodamage to normal tissues and deeper penetration to lesion areas. In this study, we report a successful synthesis of a polymer capable of undergoing partial degradation upon irradiation with NIR light by conjugating 10-N-carbamoyl linkage methylene blue (MB) moiety, a NIR photocleavable ligand, with polyethylene glycol (PEG). Through effective coupling of MB, a hydrophobic moiety, to the hydrophilic PEG molecule, an amphiphilic polymer was synthesized, as demonstrated by a lowered surface tension (55 mN/m at 0.1% wt/vol). Subsequently, photo-induced reversal of surface activity associated with self-assembled structure disruption, was displayed by surface tension measurements, size distribution analysis, and burst release profile of paclitaxel (PTX) from polymeric micelles upon the exposure to NIR irradiation.     

Autonomous landing at unprepared sites by a full-scale helicopter

Helicopters are valuable since they can land at unprepared sites; however, current unmanned helicopters are unable to select or validate landing zones (LZs) and approach paths. For operation in unknown terrain it is necessary to assess the safety of a LZ. In this paper, we describe a lidar-based perception system that enables a full-scale autonomous helicopter to identify and land in previously unmapped terrain with no human input.We describe the problem, real-time algorithms, perception hardware, and results. Our approach has extended the state of the art in terrain assessment by incorporating not only plane fitting, but by also considering factors such as terrain/skid interaction, rotor and tail clearance, wind direction, clear approach/abort paths, and ground paths.In results from urban and natural environments we were able to successfully classify LZs from point cloud maps. We also present results from 8 successful landing experiments with varying ground clutter and approach directions. The helicopter selected its own landing site, approaches, and then proceeds to land. To our knowledge, these experiments were the first demonstration of a full-scale autonomous helicopter that selected its own landing zones and landed.     

Mitigation of ammonia-induced SCC in a cupronickel alloy by additions of MgCl<Subscript>2</Subscript>

The work presented in Part 1 of this article showed that additions of magnesium chloride (MgCl₂) to ammonia solutions reduced the tendency of ammonia-induced stress-corrosion cracking (SCC) initiation in a Cu-5%Ni alloy. The present work was undertaken to study the SCC behavior of the test alloy exposed to ammonia in the presence of varying concentrations of MgCl₂. The exposure to MgCl₂ additions reduced the severity of the ammonia-induced SCC.     

A cyclic policy for the loading of multiple products on a vehicle with different compartment sizes

In this paper, we address a multi-product loading problem in which a vehicle (a truck or a ship) is used to transfer multiple products. The product demands are different but stationary over time. The vehicle consists of compartments of different sizes and each compartment can contain only one product type during each shipment. No shortages are permitted, and we assume that the inventory holding cost is significantly lower than the delivery cost. The objective is to minimize the setup rate, that is, the number of deliveries per time unit. A cyclic policy is shown to be optimal, and a heuristic algorithm is developed to determine the cycle length as well as the assignments of products to the compartments during each of the requisite number of shipments made during that cycle. A comparison of the solutions obtained by the proposed algorithm with the optimal solutions (or a bound) indicate that the algorithm provides solutions with optimal setup rates in most of the problem instances considered and, when not optimal, the setup rates of these solutions are close to optimal values.     

The Effect of Distribution on Product Temperature Profile in Thermally Insulated Containers for Express Shipments

An uninterrupted cold chain is a continual series of storage and distribution activities that maintain a specific temperature or temperature range. Cold chain solutions typically involve excessive packaging to ensure that the desired product temperature is maintained through the distribution process, thereby increasing the logistics‐related costs. There is a myriad of solutions available for shipping temperature‐sensitive products, including those constructed with a variety of packaging materials as well as refrigerants. Although static characteristics for thermally insulated packaging solutions such as the R‐values of package systems as well as the melting points and heat absorption rates of various refrigerants have been studied in the past, none of the past studies have evaluated the effect of comprehensive distribution on the reliability of the cold chain packaging solutions. This research was undertaken to study the temperature profiles for factors such as different densities for a given thickness of thermally insulating material, wall thicknesses and distribution environments for four different types of materials—polyurethane, virgin expanded polystyrene, recycled content expanded polystyrene and vacuum‐insulated panels. The temperature range of 2 °C–8 °C, critical for pharmaceutical drugs and vaccines, was targeted. An interesting regression‐based finding was that the interaction between the R‐value and the wall thickness significantly influenced the length of time the thermally insulated packages stayed in the desired range of 2 °C–8 °C . The findings of this study will be decisive in designing cost‐efficient and practical single‐use cold chain transportation solutions for temperature‐sensitive products. Copyright © 2012 John Wiley & Sons, Ltd.     

基于文渊阁彩画科学分析的清官式彩画描渍工艺解读与复原

描渍是一种现已失传的清官式建筑彩画绘制工艺,经文献研究与实例调研发现,文渊阁大木彩画中仍留存有该工艺的使用痕迹,且现存彩画包含自始建年代至清末的多次修缮遗迹。本文以文渊阁勘察项目为依托,采用剖面显微分析和偏光显微分析等科技考古手段,结合文献研究,揭示出文渊阁彩画中描渍工艺的用料与操作特征,并通过实验的方式对此工艺进行复原。     

Bio‐diesel lubricity: correlation study with residual acidity

Bio‐diesel has been accepted as a renewable liquid biofuel worldwide. In order to ensure customers' acceptance, standardisation and quality assurance are the key factors to the market introduction of bio‐diesel as a transport fuel. Lubricity of bio‐diesel is an important issue and it is well reported that 1–2% bio‐diesel is sufficient to maintain the lubricity of diesel even of very poor lubricity. However, a wide variation in lubricity performance of bio‐diesel from different vegetable oils and sources has been noticed. In addition, on critical examination, it was noticed that the variation in the lubricating performance of bio‐diesel could be better linked to its residual acidity than to variation in fatty acid composition. Copyright © 2007 John Wiley & Sons, Ltd.     

Modified Transfer Equation Approach and its application to linearized plane couette flow

Conclusion The main aim of the present paper is to give a more general formulation for velocity distribution function and in consequence the advantages of the present method are discussed in detail in comparison with other methods, particularly that of Shen. The method is then applied to the problem of plane linearized couette flow and the method of analysis is outlined. Moreover, the method seems to be suitable for non-linear cases. Further work on the applicability of the present method is in progress and it will be published soon.