Single nucleotide polymorphism data analysis - State-of-the-art review on this emerging field from a signal processing viewpoint

The basic structural units of the genome are nucleotides. A single nucleotide polymorphism (SNP) is a mutation at a single nucleotide position. This paper discusses several major problems in SNP data analysis and review some existing solutions in this work. Generally speaking, a rich set of SNP analysis problems are cast in the signal processing framework. Our objective is to offer a state-of-the art review on this topic from a signal processing viewpoint so that researchers in the signal processing field can grasp the important domain knowledge to overcome the barrier between the two fields     

Parameter determination of support vector machine and feature selection using simulated annealing approach

Support vector machine (SVM) is a novel pattern classification method that is valuable in many applications. Kernel parameter setting in the SVM training process, along with the feature selection, significantly affects classification accuracy. The objective of this study is to obtain the better parameter values while also finding a subset of features that does not degrade the SVM classification accuracy. This study develops a simulated annealing (SA) approach for parameter determination and feature selection in the SVM, termed SA-SVM.To measure the proposed SA-SVM approach, several datasets in UCI machine learning repository are adopted to calculate the classification accuracy rate. The proposed approach was compared with grid search which is a conventional method of performing parameter setting, and various other methods. Experimental results indicate that the classification accuracy rates of the proposed approach exceed those of grid search and other approaches. The SA-SVM is thus useful for parameter determination and feature selection in the SVM.     

Coping knowledge boundaries between information system and business disciplines: An intellectual capital perspective

Information system development can be considered a collaboration between users and developers. The inability to leverage the localized knowledge embedded in these two stakeholders hinders software development work to achieve high performance. Exploring the ways to counter this difficulty is then critical. This study applies an intellectual capital perspective to address the issues around spanning the knowledge boundary between developers and users. Our findings highlighted how important effective knowledge boundary spanning is to both product and project quality. Furthermore, three dimensions of intellectual capital increased the degree to which knowledge boundary spanning was effective.     

B2O3-free SiO2–Al2O3–SrO–La2O3–ZnO–TiO2 glass sealants for intermediate temperature solid oxide fuel cell applications

In this study, the chemical and thermal stabilities of eleven B₂O₃-free SiO₂–Al₂O₃–SrO–La₂O₃–ZnO–TiO₂ glasses were investigated, and the adhesion and sealing properties of the glasses with respect to Gd_0.2Ce_0.8O_2−δ (GDC) electrolyte and SUS 430 stainless steel (SUS430) were evaluated for use in intermediate temperature solid oxide fuel cells (ITSOFCs). It was found that the major crystallites formed in the glasses were initiated during the joining process at 950 °C, and only slight changes were observed in the intensity of crystallite peaks for the glasses subsequently soaked at 700 °C for 200 h. Experiments on the glass sandwiched with GDC electrolyte and SUS430 indicated that the SALSTi11 and SALSZT10 glasses provided good adhesion along the interfaces after heat treatment. According to the results of leakage test, the seals with the SALSTi11 and SALSZT10 glasses at 700 °C for a duration of 500 h showed good thermal stability with low leak rates of 0.007 and 0.003 sccm/cm at 0.5 psi, respectively. This property indicates a highly promising long-term thermal stability qualifying the sealing materials for ITSOFC applications.     

White-light fluorescent nanoparticles from self-assembly of rhodamine B-anchored amphiphilic poly(poly(ethylene glycol)methacrylate)-b-poly(glycidyl methacrylate) block copolymer

Rhodamine B (RhB)-anchored amphiphilic poly(poly(ethylene glycol)methacrylate)-b-poly(glycidyl methacrylate) block copolymer (PPEGMA-b-PGMA/RhB) has been prepared by a sequential atom transfer radical polymerization and post-functionalization of RhB. The chemical structure of PPEGMA-b-PGMA/RhB is characterized with gel-permeation chromatography, Fourier-transform infrared spectroscopy, and ¹H nuclear magnetic resonance spectroscopy. PPEGMA-b-PGMA/RhB has shown self-assembly behaviors in tetrahydrofuran and aqueous solutions. The RhB aggregation induced with the inter-molecular interaction of RhB results in the various core–shell structures of the assembled nanoparticles. The photoluminescent properties of the PPEGMA-b-PGMA/RhB nanoparticles are structure-dependent and exhibit yellow-light, blue-light, and white-light emissions. The fluorescent organic nanoparticles of PPEGMA-b-PGMA/RhB in aqueous solution show low cytotoxicity and have been used as a bio-dye for cell labelling. Internalization of PPEGMA-b-PGMA/RhB nanoparticles into HELA cells to exhibit fluorescent images has been demonstrated.     

Tracking R&;D behavior: bibliometric analysis of drug patents in the Orange Book

The Publication Approved Drug Products with Therapeutic Equivalence Evaluations (commonly known as the Orange Book) identifies drug products approved by the United States Food and Drug Administration (USFDA) for safety and effectiveness, and provides substantial information on new drug applications (NDAs) with patent data. To explore the patterns among drug patents in the Orange Book, this study used patent bibliometric analysis. The productivity and impact are presented at the assignee level and applicant level, respectively, and the applicant’s patent portfolio is further discussed. 2,033 drug patents are identified in this current study. Our findings indicate that the applicant’s patent portfolio in the Orange Book is helpful in revealing the technological capability and patent strategy of the pharmaceutical incumbents. By linking drug data and patent information, this current study sheds light on patent research in the pharmaceutical industry.     

A beam-scanning and polarization-agile antenna array using mutually coupled oscillating doublers

In this paper, a two-dimensional mutually coupled oscillator array is studied for the application of a beam-scanning and polarization-agile antenna array. In the design of antenna array, a two-dimensional oscillator array is implemented in x-y plane, the polarization agility is provided by one dimension (or y-direction) and the other dimension (or x-direction) is for beam scanning. By properly tuning the free-running frequencies of these oscillators, the array radiation direction can be scanned at the selected polarization states including linearly polarized, left-hand and right-hand circularly polarized states. The maximal phase difference of /spl plusmn/180/spl deg/ between coupled oscillating signals is acquired by utilizing their second-harmonic signals. This then gives well-defined phase differences among oscillators for beam scanning in addition to the required quadrature phase difference for circular polarization. The performances of polarization agility and beam scanning for a four-element antenna array are verified experimentally and shown to have the potential for adaptive antenna array applications.     

ZBP: A Zone-Based Broadcasting Protocol for Wireless Sensor Networks

Wireless Sensor Networks (WSNs) have been widely used in motoring and collecting interests of environment information. Packet flooding or broadcasting is an essential function for establishing a communication path from sink node to a region of sensor nodes. However, flooding operation consumes power and bandwidth resources and raises the packet collision and contention problems, which reduce the success rate of packet transmissions and consume energy. This article proposes an efficient broadcasting protocol to reduce the number of sensor nodes that forward the query request, hence improves the packet delivery rate and saves bandwidth and power consumptions. Sensor node that received the query request will dynamically transfers the coordinate system according to the zone-ID of source node and determines whether it would forward the request or not in a distributed manner. Compared with the CBM and traditional flooding operation, experimental results show that the proposed zone-based broadcasting protocol decreases the bandwidth and power consumptions, reduces the packet collisions, and achieves high success rate of packet broadcasting.Chih-Yung Chang received the Ph.D. degree in Computer Science and Information Engineering from National Central University, Taiwan, in 1995. He joined the faculty of the Department of Computer and Information Science at Aletheia University, Taiwan, as an Assistant Professor in 1997. He was the Chair of the Department of Computer and Information Science, Aletheia University, from August 2000 to July 2002. He is currently an Associate Professor of Department of Computer Science and Information Engineering at Tamkang University, Taiwan. Dr. Chang served as an Associate Guest Editor of Journal of Internet Technology (JIT), Special Issue on “Wireless Ad Hoc and Sensor Networks” (2004) and a member of Editorial Board of Tamsui Oxford Journal of Mathematical Sciences (2001–2005). He was an Area Chair of IEEE AINA′2005, Vice Chair of IEEE WisCom2005, Track Chair (Learning Technology in Education Track) of IEEE ITRE′2005, Program Co-Chair of MNSA′2005, Workshop Co-Chair of INA′2005, MSEAT′2003, MSEAT′2004, Publication Chair of MSEAT′2005, and the Program Committee Member of ICPP′2004, USW′2005, WASN′2005, and the 11th Mobile Computing Workshop. Dr. Chang is a member of the IEEE Computer Society and IEICE society. His current research interests include wireless sensor networks, mobile learning, Bluetooth radio systems, Ad Hoc wireless networks, and mobile computing.Kuei-Ping Shih received the B.S. degree in Mathematics from Fu-Jen Catholic University, Taiwan, Republic of China, in June 1991 and the Ph.D. degree in Computer Science and Information Engineering from National Central University, Taiwan, Republic of China, in June 1998. After two years of military obligation, he joined the faculty of the Department of Computer Science and Information Engineering, Tamkang University, Taiwan, Republic of China, as an assistant professor in 2000. Dr. Shih served as a Program Area Chair in the IEEE International Conference on Advanced Information Networking and Applications (AINA), 2005, and as a Technical Track Chair in the IEEE International Conference on Information Technology: Research and Education (ITRE), 2005. Dr. Shih’s current research interests include wireless networks, sensor networks, mobile computing, and network protocols design.Dr. Shih is a member of the IEEE Computer and Communication Societies and Phi Tau Phi Scholastic Honor Society.Shih-Chieh Lee received the B.S. degree in Computer Science and Information Engineering from Tamkang University, Taiwan, in 1997. Since 2003 he has been a Ph.D. Students in Department of Computer Science and Information Engineering, Tamkang University. His research interests are wireless sensor networks, Ad Hoc wireless networks, and mobile/wireless computing.     

Hydrophilic UV-curable PU resins for PET micro-fiber applications

Hydrophilic UV-curable PU oligomers (UV-PU) were prepared by mixing either the toluene diisocyanates (TDI) with polyethylene glycol-1000, or the isophorone diisocyanate (IPDI) with polypropylene glycol-1000 and dimethylol propanic acid (DMPA), to produce the desired carboxylic acid bearing or non-ionic PU oligmer (NCO-PU), separately. The 2-hydroxyethyl methacrylate (HEMA) was then added into the NCO-PU oligomer to form acrylate-terminated (UV-curable) PU oligomer (UV-PU). The reactive diluents, such as 1,6-hexanediol diacrylate (HDDA), trimethylolpropane tricarylate (TMPTA) and others were used to adjust the viscosity of UV-PU and to control the concentration of acrylic group. The hydrophilic UV-curable PU system was formulated and applied on PET micro-fiber and then cured by an UV-radiation at ambient temperature. The physical, thermal, and mechanical properties, in particular, the hydrophilic properties of UV-curable PU treated PET micro-fibers will be discussed.     

Surface Properties of Glucose-Based Surfactants and Their Application in Textile Dyeing with Natural Dyes

In this study, propylene glycol-based glycosides were obtained using an acetalization reaction in which glucose was first reacted with propylene glycol. Subsequently, the propylene glycol glycoside was reacted with alkyl glycidyl ether of varying carbon chain lengths (i.e., 08-G, 10-G, 12-G, 14-G, and 16-G) to synthesize a series of glucose-based biodegradable surfactants. The experimental results show that the surface activity of the C₈–C₁₂ glucose-based surfactants increases with the carbon chain length. However, the surface activity of the C₁₄–C₁₆ glucose-based surfactants decreased as the carbon chain length increased. Among all the surfactants, the C₁₂ glucose-based surfactant exhibited the most efficient emulsification ability, lowest surface tension, lowest fluorescence intensity, highest zeta potential, and good emulsification stability. The glucose-based surfactants were used as additives in natural plant dyes made from turmeric or henna to dye wool fabrics. Higher color strengths were observed in the C₁₄ glucose-based surfactant.