The TSIMMIS Approach to Mediation: Data Models and Languages

TSIMMIS—The Stanford-IBM Manager of Multiple InformationSources—is a system for integrating information. It offers a datamodel and a common query language that are designed to support thecombining of information from many different sources. It also offerstools for generating automatically the components that are needed tobuild systems for integrating information. In this paper we shalldiscuss the principal architectural features and their rationale.     

Studying transverse volume discharge in a helium-propane mixture

The electrical properties and emission characteristics of plasma formed in a transverse volume discharge in helium-propane (He-C₆H₁₄) mixtures at a total pressure of 3–15 kPa have been studied. The spatial parameters, plasma emission spectra, and current and voltage oscillograms of the discharge, as well as the yield of carbon-containing products of propane decomposition at various pressures and compositions of the He-C₆H₁₄ gas mixture, have been determined.     

A high-power low-pressure iodine lamp pumped by glow discharge

We present the working characteristics of a high-power UV-VUV electric-discharge lamp filled with a working mixture of helium and iodine vapor (He-I₂) at a low pressure (0.1–1.5 kPa) and pumped by a dc glow discharge at a power of 15–200 W. The power of the total output UV radiation and the main emission peak at λ = 206.2 nm were studied as dependent on the electric power supplied to the glow discharge and on the partial pressure of helium in the He-I₂ mixture. The emission characteristics of the glow discharge plasma were studied in the spectral range from 200 to 350 nm. In this range, the lamp is operating predominantly on a resonance emission line of excited iodine atoms (λ = 206.2 nm, FWHM = 0.10–0.12 nm) and on a system of electronic-vibrational bands of excited iodine molecules with the main peak at λ = 342 nm. The contribution of the resonance emission due to excited iodine atoms to the total UV emission from the glow discharge plasma does not exceed 50%. The optimum partial pressure of helium is within 400–800 Pa. The total UV radiation power of the lamp operating in the optimum regime reaches 25 W at an efficiency of η ≤15%.     

Querying websites using compact skeletons

Several commercial applications, such as online comparison shopping and process automation, require integrating information that is scattered across multiple websites or XML documents. Much research has been devoted to this problem, resulting in several research prototypes and commercial implementations. Such systems rely on wrappers that provide relational or other structured interfaces to websites. Traditionally, wrappers have been constructed by hand on a per-website basis, constraining the scalability of the system. We introduce a website structure inference mechanism called compact skeletons that is a step in the direction of automated wrapper generation. Compact skeletons provide a transformation from websites or other hierarchical data, such as XML documents, to relational tables. We study several classes of compact skeletons and provide polynomial-time algorithms and heuristics for automated construction of compact skeletons from websites. Experimental results show that our heuristics work well in practice. We also argue that compact skeletons are a natural extension of commercially deployed techniques for wrapper construction.     

Generalization to Novel Views: Universal,Class-based,and Model-based Processing

A major problem in object recognition is that a novel image of a given object can be different from all previously seen images. Images can vary considerably due to changes in viewing conditions such as viewing position and illumination. In this paper we distinguish between three types of recognition schemes by the level at which generalization to novel images takes place: universal, class, and model-based. The first is applicable equally to all objects, the second to a class of objects, and the third uses known properties of individual objects. We derive theoretical limitations on each of the three generalization levels. For the universal level, previous results have shown that no invariance can be obtained. Here we show that this limitation holds even when the assumptions made on the objects and the recognition functions are relaxed. We also extend the results to changes of illumination direction. For the class level, previous studies presented specific examples of classes of objects for which functions invariant to viewpoint exist. Here, we distinguish between classes that admit such invariance and classes that do not. We demonstrate that there is a tradeoff between the set of objects that can be discriminated by a given recognition function and the set of images from which the recognition function can recognize these objects. Furthermore, we demonstrate that although functions that are invariant to illumination direction do not exist at the universal level, when the objects are restricted to belong to a given class, an invariant function to illumination direction can be defined. A general conclusion of this study is that class-based processing, that has not been used extensively in the past, is often advantageous for dealing with variations due to viewpoint and illuminant changes.     

Can imageability help us draw the line between storage and composition?

Language requires both storage and composition. However, exactly what is retrieved from memory and what is assembled remains controversial, especially for inflected words. Here, “imageability effects” is introduced as a new diagnostic of storage and a complement to frequency effects. In 2 studies of past-tense morphology, more reliable imageability and frequency effects were found on irregulars than on regulars. An interaction with sex was also observed: Males but not females showed more reliable frequency and imageability effects for irregulars than for regulars; females but not males showed signs of storage for regulars, particularly among higher frequency forms. Overall, the findings validate imageability effects as another diagnostic of storage and suggest that the line between storage and computation is not a simple function; rather, it depends upon the interplay of both item- and subject-specific factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phospholipid Cyclosporine Prodrugs Targeted at Inflammatory Bowel Disease (IBD) Treatment: Design,Synthesis, and in Vitro Validation

Novel phospholipid (PL)-cyclosporine conjugates were prepared and studied as potential prodrugs for inflammatory bowel disease (IBD). Our approach relies on phospholipase A₂ (PLA₂), which is overexpressed in the inflamed intestinal tissues, as the prodrug activator to potentially release cyclosporine at the site of inflammation. PL-cyclosporine prodrug conjugates with methylene linkers of various lengths between the sn-2 position of the PL and cyclosporine were synthesized and evaluated for in vitro activation. Surprisingly, despite previous work indicating that conjugates with six methylene linkers between the lipid and drug would suffer rapid enzymatic hydrolysis, with cyclosporine this was not observed. However, compounds with longer linkers (n=10, 12 methylene units) display complete release of the drug by PLA₂-catalyzed hydrolysis, thus demonstrating the importance and profound impact of structural fine-tuning. This study represents a proof-of-concept for our hypothesis and a first step towards a truly targeted IBD treatment with cyclosporine that could be administered throughout the GI tract.