The temporomandibular joint (TMJ) and osteogenesis imperfecta. A study of its embryologic development

Although the most common oral manifestation of osteogenesis imperfecta is dentinogenesis imperfecta, several authors have described jaw fractures and radiolucent bone lesions associated with this disease. The authors, after reporting the main features of this disease, compare the cranial embryologic growth in twice fetuses of a 15 weeks old: one of these with osteogenesis imperfecta.     

A complete and efficient CUDA-sharing solution for HPC clusters

In this paper we detail the key features, architectural design, and implementation of rCUDA, an advanced framework to enable remote and transparent GPGPU acceleration in HPC clusters. rCUDA allows decoupling GPUs from nodes, forming pools of shared accelerators, which brings enhanced flexibility to cluster configurations. This opens the door to configurations with fewer accelerators than nodes, as well as permits a single node to exploit the whole set of GPUs installed in the cluster. In our proposal, CUDA applications can seamlessly interact with any GPU in the cluster, independently of its physical location. Thus, GPUs can be either distributed among compute nodes or concentrated in dedicated GPGPU servers, depending on the cluster administrator’s policy. This proposal leads to savings not only in space but also in energy, acquisition, and maintenance costs. The performance evaluation in this paper with a series of benchmarks and a production application clearly demonstrates the viability of this proposal. Concretely, experiments with the matrix–matrix product reveal excellent performance compared with regular executions on the local GPU; on a much more complex application, the GPU-accelerated LAMMPS, we attain up to 11x speedup employing 8 remote accelerators from a single node with respect to a 12-core CPU-only execution. GPGPU service interaction in compute nodes, remote acceleration in dedicated GPGPU servers, and data transfer performance of similar GPU virtualization frameworks are also evaluated.     

The development of railway safety in Finland

This study reviews the development of railway safety in Finland from 1959 to 2008. The results show that the level of safety has greatly improved over the past five decades. The total number of railway fatalities did not show any obvious decreasing or increasing trend during the first decade, but since the early 1970s the annual number of fatalities has decreased from about 100 to 20. The estimated overall annual reduction per year from 1970 to 2008 was 5.4% (with a 95% confidence interval from −8.2% to −2.6%). The reduction in subcategories per million train-kilometres from 1959 to 2008 was 4.4% per year for passengers, 8.3% for employees, 5.0% for road users at level crossings and 3.6% for others (mainly trespassers). The safety improvement for passengers and staff was probably influenced by the introduction of central locking of doors in passenger cars and improved procedures to protect railway employees working on the tracks. The number of road users killed at level crossings has fallen due to the installation of barriers and the construction of overpasses and underpasses at crossings with dense traffic, removal of level crossings, and an improvement of conditions such as visibility at crossings. The number of trespasser fatalities has seen the least decline. Key plans for the future include further reduction of the number of level crossings on the state railway network from the current roughly 3500–2200 by 2025, and involving communities in safety work related to railway trespassers.     

Potentiation of lysis of leukaemia cells by a bispecific antibody to CD33 and CD16 (Fc gamma RIII) expressed by human natural killer (NK) cells

Bispecific antibodies recognizing tumour-associated antigens and trigger molecules expressed on immune effector cells have been shown to redirect cytotoxicity of several types of peripheral blood cells against relevant tumour targets. Among various effector cells, natural killer (NK) cells appear to play a role in defence against leukaemia. Here we report the successful chemical conjugation of monoclonal antibodies to CD33 and CD16 to create a bispecific antibody (BsAb 251 x 3G8). This bispecific antibody is capable of augmenting the killing of otherwise resistant leukaemia cells by peripheral blood lymphocytes (PBL), purified resting NK (R-NK) cells, and activated NK (A-NK) cells. BsAb 251 x 3G8 may play a role in the therapy of acute myeloid leukaemia (AML) through redirecting the cytotoxic activity of endogenous or adoptively transferred NK cells.     

Effect of three countermeasures against the illegal crossing of railway tracks

This study was designed to investigate the effects of three countermeasures – landscaping, building a fence and prohibitive signs – on the frequency of trespassing, which in this case means crossing the track at places where it is forbidden. At each location the official route was no more than 300 m away. The main results showed that the effect of each countermeasure on the frequency of trespassing was statistically significant. Specifically, the fencing reduced trespassing by 94.6%, followed by landscaping (91.3%) and prohibitive signs (30.7%). The majority of illegal crossings were committed alone and the persons trespassing were mostly adults and men. In addition, the results demonstrated some tendencies of how the effects of the selected countermeasures can vary with the characteristics of the trespassers. The main implication of this study is that the building of physical barriers such as landscaping or fencing is recommended for reducing trespassing. However, if the required resources are not available or the site is not suitable for such measures, the use of prohibitive signs is recommended. Further, there is a need to tailor the countermeasures to the characteristics of the trespassers in order to ensure that the most appropriate countermeasures are applied.     

Deformation of the compound middle lamella in spruce latewood by micro-pillar compression of double cell walls

The mechanical integrity of the interface between two adjacent cells in spruce late wood was studied by uniaxial compression of focused ion beam machined micro-pillars of double cell walls (DCW) containing the compound middle lamella (CML). The DCW reveals a lower yield strength and stiffness than the secondary cell wall (S2). Failure occurs by tearing of the interface between the first (S1) and second layers (S2) of the secondary cell wall exposing the internal arrangement of the microfibrils, while the CML remains intact.     

3H]aniracetam binds to specific recognition sites in brain membranes

[3H]Aniracetam bound to specific and saturable recognition sites in membranes prepared from discrete regions of rat brain. In crude membrane preparation from rat cerebral cortex, specific binding was Na+ independent, was still largely detectable at low temperature (4 degrees C), and underwent rapid dissociation. Scatchard analysis of [3H]aniracetam binding revealed a single population of sites with an apparent KD value of approximately 70 nM and a maximal density of 3.5 pmol/mg of protein. Specifically bound [3H]aniracetam was not displaced by various metabolites of aniracetam, nor by other pyrrolidinone-containing nootropic drugs such as piracetam or oxiracetam. Subcellular distribution studies showed that a high percentage of specific [3H]aniracetam binding was present in purified synaptosomes or mitochondria, whereas specific binding was low in the myelin fraction. The possibility that at least some [3H]aniracetam binding sites are associated with glutamate receptors is supported by the evidence that specific binding was abolished when membranes were preincubated at 37 degrees C under fast shaking (a procedure that substantially reduced the amount of glutamate trapped in the membranes) and could be restored after addition of either glutamate or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) but not kainate. The action of AMPA was antagonized by DNQX, which also reduced specific [3H]aniracetam binding in unwashed membranes. High levels of [3H]aniracetam binding were detected in hippocampal, cortical, or cerebellar membranes, which contain a high density of excitatory amino acid receptors.(ABSTRACT TRUNCATED AT 250 WORDS)     

A low-latency modular switch for CMP systems

As technology advances, the number of cores in Chip MultiProcessor systems and MultiProcessor Systems-on-Chips keeps increasing. The network must provide sustained throughput and ultra-low latencies.In this paper we propose new pipelined switch designs focused in reducing the switch latency. We identify the switch components that limit the switch frequency: the arbiter. Then, we simplify the arbiter logic by using multiple smaller arbiters, but increasing greatly the switch area. To solve this problem, a second design is presented where the routing traversal and arbitrations tasks are mixed. Results demonstrate a switch latency reduction ranging from 10% to 21%. Network latency is reduced in a range from 11% to 15%.     

OMR metrics and evaluation: a systematic review

Multimedia Tools and Applications - Music is rhythm, timbre, tones, intensity and performance. Conventional Western Music Notation (CWMN) is used to generate Music Scores in order to register music...     

Improving the user experience of the rCUDA remote GPU virtualization framework

Graphics processing units (GPUs) are being increasingly embraced by the high‐performance computing community as an effective way to reduce execution time by accelerating parts of their applications. remote CUDA (rCUDA) was recently introduced as a software solution to address the high acquisition costs and energy consumption of GPUs that constrain further adoption of this technology. Specifically, rCUDA is a middleware that allows a reduced number of GPUs to be transparently shared among the nodes in a cluster. Although the initial prototype versions of rCUDA demonstrated its functionality, they also revealed concerns with respect to usability, performance, and support for new CUDA features. In response, in this paper, we present a new rCUDA version that (1) improves usability by including a new component that allows an automatic transformation of any CUDA source code so that it conforms to the needs of the rCUDA framework, (2) consistently features low overhead when using remote GPUs thanks to an improved new communication architecture, and (3) supports multithreaded applications and CUDA libraries. As a result, for any CUDA‐compatible program, rCUDA now allows the use of remote GPUs within a cluster with low overhead, so that a single application running in one node can use all GPUs available across the cluster, thereby extending the single‐node capability of CUDA. Copyright © 2014 John Wiley & Sons, Ltd.