全文获取类型
收费全文 | 38551篇 |
免费 | 14853篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 727篇 |
综合类 | 3篇 |
化学工业 | 17750篇 |
金属工艺 | 323篇 |
机械仪表 | 729篇 |
建筑科学 | 1718篇 |
矿业工程 | 6篇 |
能源动力 | 861篇 |
轻工业 | 7414篇 |
水利工程 | 296篇 |
石油天然气 | 48篇 |
无线电 | 6860篇 |
一般工业技术 | 11525篇 |
冶金工业 | 631篇 |
原子能技术 | 6篇 |
自动化技术 | 4508篇 |
出版年
2024年 | 4篇 |
2023年 | 47篇 |
2022年 | 190篇 |
2021年 | 412篇 |
2020年 | 1481篇 |
2019年 | 3234篇 |
2018年 | 3145篇 |
2017年 | 3468篇 |
2016年 | 3943篇 |
2015年 | 4011篇 |
2014年 | 3931篇 |
2013年 | 5057篇 |
2012年 | 2769篇 |
2011年 | 2438篇 |
2010年 | 2728篇 |
2009年 | 2570篇 |
2008年 | 2099篇 |
2007年 | 1929篇 |
2006年 | 1687篇 |
2005年 | 1390篇 |
2004年 | 1348篇 |
2003年 | 1325篇 |
2002年 | 1275篇 |
2001年 | 1104篇 |
2000年 | 1064篇 |
1999年 | 460篇 |
1998年 | 51篇 |
1997年 | 42篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 23篇 |
1993年 | 18篇 |
1992年 | 16篇 |
1991年 | 16篇 |
1990年 | 13篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 10篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1978年 | 6篇 |
1969年 | 1篇 |
1961年 | 1篇 |
1955年 | 1篇 |
1890年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Katia Varani Fabrizio Vincenzi Silvia Pasquini Irene Blo Simona Salati Matteo Cadossi Monica De Mattei 《International journal of molecular sciences》2021,22(2)
Mesenchymal stem cells (MSCs) are the main cell players in tissue repair and thanks to their self-renewal and multi-lineage differentiation capabilities, they gained significant attention as cell source for tissue engineering (TE) approaches aimed at restoring bone and cartilage defects. Despite significant progress, their therapeutic application remains debated: the TE construct often fails to completely restore the biomechanical properties of the native tissue, leading to poor clinical outcomes in the long term. Pulsed electromagnetic fields (PEMFs) are currently used as a safe and non-invasive treatment to enhance bone healing and to provide joint protection. PEMFs enhance both osteogenic and chondrogenic differentiation of MSCs. Here, we provide extensive review of the signaling pathways modulated by PEMFs during MSCs osteogenic and chondrogenic differentiation. Particular attention has been given to the PEMF-mediated activation of the adenosine signaling and their regulation of the inflammatory response as key player in TE approaches. Overall, the application of PEMFs in tissue repair is foreseen: (1) in vitro: to improve the functional and mechanical properties of the engineered construct; (2) in vivo: (i) to favor graft integration, (ii) to control the local inflammatory response, and (iii) to foster tissue repair from both implanted and resident MSCs cells. 相似文献
2.
Bijan Nasri‐Nasrabadi Akif Kaynak Shayan Seyedin Zahra Komeily‐Nia Abbas Z Kouzani 《Polymer International》2019,68(5):922-928
Recent advances in three‐dimensional (3D) printing have enabled the fabrication of interesting structures which are not achievable using traditional fabrication approaches. The 3D printing of carbon microtube composite inks allows fabrication of conductive structures for practical applications in soft robotics and tissue engineering. However, it is challenging to achieve 3D printed structures from solution‐based composite inks, which requires an additional process to solidify the ink. Here, we introduce a wet 3D printing technique which uses a coagulation bath to fabricate carbon microtube composite structures. We show that through a facile nanogrooving approach which introduces cavitation and channels on carbon microtubes, enhanced interfacial interactions with a chitosan polymer matrix are achieved. Consequently, the mechanical properties of the 3D printed composites improve when nanogrooved carbon microtubes are used, compared to untreated microtubes. We show that by carefully controlling the coagulation bath, extrusion pressure, printing distance and printed line distance, we can 3D print composite lattices which are composed of well‐defined and separated printed lines. The conductive composite 3D structures with highly customised design presented in this work provide a suitable platform for applications ranging from soft robotics to smart tissue engineering scaffolds. © 2019 Society of Chemical Industry 相似文献
3.
Marco Bocchetti Maria Grazia Ferraro Filippo Ricciardiello Alessandro Ottaiano Amalia Luce Alessia Maria Cossu Marianna Scrima Wing-Yan Leung Marianna Abate Paola Stiuso Michele Caraglia Silvia Zappavigna Tung On Yau 《International journal of molecular sciences》2021,22(8)
Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment. 相似文献
4.
Karolina Storesund Francine Amon Anne Steen‐Hansen Shayesteh Haghighatpanah Ida Larsson 《火与材料》2021,45(1):181-190
The aim of this exploratory study has been to investigate the fire properties and environmental aspects of different upholstery material combinations, mainly for domestic applications. An analysis of the sustainability and circularity of selected textiles, along with lifecycle assessment, is used to qualitatively evaluate materials from an environmental perspective. The cone calorimeter was the primary tool used to screen 20 different material combinations from a fire performance perspective. It was found that textile covers of conventional fibres such as wool, cotton and polyester, can be improved by blending them with fire resistant speciality fibres. A new three‐dimensional web structure has been examined as an alternative padding material, showing preliminary promising fire properties with regard to ignition time, heat release rates and smoke production. 相似文献
5.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
6.
Fluorescence‐Activated Cell Sorters: Standing Surface Acoustic Wave (SSAW)‐Based Fluorescence‐Activated Cell Sorter (Small 40/2018)
下载免费PDF全文
![点击此处可从《Small (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
7.
8.
9.
SPEEK/cSMM membrane for simultaneous electricity generation and wastewater treatment in microbial fuel cell
下载免费PDF全文
![点击此处可从《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.
Efficacy of Crude and Purified Chitinases (SsChi50) Extracted from Offal Red Scorpion Fish in Biological Control of Chickpea Weevil (Callosobruchus maculatus L.)
下载免费PDF全文
![点击此处可从《Journal of Food Processing and Preservation》网站下载免费的PDF全文](/ch/ext_images/free.gif)