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排序方式: 共有75条查询结果,搜索用时 15 毫秒
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Dana Petcu Silviu Panica Marc Frîncu Marian Neagul Daniela Zaharie Georgiana Macariu Dorian Gorgan Teodor Ştefănuţ 《Computer Standards & Interfaces》2012,34(6):493-508
Earth observation data processing and storing can be done nowadays only using distributed systems. Experiments dealing with a large amount of data are possible within the timeframe of a lesson and can give trainees the freedom to innovate. Following these trends and ideas, we have built a proof-of-the-concept platform, named GiSHEO, for Earth observation educational tasks. It uses Grid computing technologies to analyze and store remote sensing data, and combines them with eLearning facilities. This paper provides an overview of the GiSHEO's platform architecture and of its technical and innovative solutions. 相似文献
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Mario Lhr Wolfgang Hrtig Almut Schulze Matthias Kroiß Silviu Sbiera Constantin Lapa Bianca Mages Sabrina Strobel Jennifer Elisabeth Hundt Simone Bohnert Stefan Kircher Sudha Janaki-Raman Camelia-Maria Monoranu 《International journal of molecular sciences》2022,23(7)
Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum cholesterol to esters for storage in lipid droplets (LD), serves as a target for the orphan drug mitotane to treat adrenocortical carcinoma. Inhibition of SOAT1 also suppresses GBM growth. Here, we refined SOAT1-expression in GBM and IDH-mutant astrocytoma, CNS WHO grade 4 (HGA), and assessed the distribution of LD in these tumors. Twenty-seven GBM and three HGA specimens were evaluated by multiple GFAP, Iba1, IDH1 R132H, and SOAT1 immunofluorescence labeling as well as Oil Red O staining. To a small extent SOAT1 was expressed by tumor cells in both tumor entities. In contrast, strong expression was observed in glioma-associated macrophages. Triple immunofluorescence labeling revealed, for the first time, evidence for SOAT1 colocalization with Iba1 and IDH1 R132H, respectively. Furthermore, a notable difference in the amount of LD between GBM and HGA was observed. Therefore, SOAT1 suppression might be a therapeutic option to target GBM and HGA growth and invasiveness. In addition, the high expression in cells related to neuroinflammation could be beneficial for a concomitant suppression of protumoral microglia/macrophages. 相似文献
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Sorin Iorga Mihai Cojocaru Adriana Chivu Sorin Ciuca Mihail Burdusel Petre Badica Cédric Leuvrey Guy Schmerber Corinne Ulhaq-Bouillet Silviu Colis 《Metallurgical and Materials Transactions A》2014,45(7):3088-3096
We report on the changes on the microstructural, hardness, and corrosion properties induced by carbo-chromization of 316L stainless steel prepared by Spark Plasma Sintering technique. The thermo-chemical treatments have been performed using pack cementation. The carburizing and chromization were carried out between 1153 K (880 °C)/4 h to 1253 K (980 °C)/12 h and 1223 K (950 °C)/6 h to 1273 K (1000 °C)/12 h in a solid powder mixture of charcoal/BaCO3 and ferrochromium/alumina/NH4Cl, respectively. The obtained layers were investigated using X-ray and electron diffraction, optical and scanning electron microscopies, Vickers micro-hardness, and potentiodynamic measurements. The thickness of the carbo-chromized layer ranges between 300 and 500 μm. Besides the host γ-phase, the layers are mainly constituted of carbides (Fe7C3, Cr23C6, Cr7C3, and Fe3C) and traces of α′-martensite. The average hardness values decrease smoothly from 650 HV at the sample surface down to 200 HV at the center of the sample. The potentiodynamic tests revealed that the carbo-chromized samples have smaller corrosion resistance with respect to the untreated material. For strong chromization regimes, the corrosion rate is increased by a factor of four with respect to that of the untreated material, while the micro-hardness of the layer is three times larger. Such materials are suited to be used in environments where good corrosion resistance and wear properties are required. 相似文献
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Monica Popa Jose Maria Calderon Moreno Cora Vasilescu Silviu Iulian Drob Elena Ionela Neacsu Andrej Coer Julija Hmeljak Gregor Zerjav Ingrid Milošev 《Metallurgical and Materials Transactions A》2014,45(7):3130-3143
This article analyses the microstructure, electrochemical behavior, and biocompatibility of a novel Ti-20Nb-10Zr-5Ta alloy with low Young’s modulus (59 GPa) much closer to that of bone, between 10 and 30 GPa, than Ti and other Ti alloys used as implant biomaterial. XRD and SEM measurements revealed a near β crystalline microstructure containing β phase matrix and secondary α phase, with a typical grain size of around 200 μm. The corrosion behavior in neutral Ringer solution evidenced: self-passivation behavior characterizing a very resistant passive film; an easy passivation as a result of favorable influence of the alloying elements Nb, Zr, and Ta that participate with their passive oxides to the formation of the alloy passive film; low corrosion and ion release rates corresponding with very low toxicity. In MEM solution, the novel alloy demonstrated very high corrosion resistance and no susceptibility to localized corrosion. Biocompatibility was evaluated on in vitro human osteoblast-like and human immortalized pulmonary fibroblast cell (Wi-38) lines and the new Ti-20Nb-10Zr-5Ta alloy exhibited no cytotoxicity. The new Ti-20Nb-10Zr5Ta alloy is a promising material for implants due to combined properties of low elastic modulus, very low corrosion rate, and good biocompatibility. 相似文献
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Claudia Mihaela Ninciuleanu Raluca Ianchi Elvira Alexandrescu Ctlin Ionu Mihescu Sabina Burlacu Bogdan Tric Cristina Lavinia Nistor Silviu Preda Cristina Scomoroscenco Ctlina Gîfu Cristian Petcu Mircea Teodorescu 《International journal of molecular sciences》2022,23(18)
The present work aims to show how the main properties of poly(methacrylic acid) (PMAA) hydrogels can be engineered by means of several silicon-based fillers (Laponite XLS/XLG, montmorillonite (Mt), pyrogenic silica (PS)) employed at 10 wt% concentration based on MAA. Various techniques (FT-IR, XRD, TGA, SEM, TEM, DLS, rheological measurements, UV-VIS) were used to comparatively study the effect of these fillers, in correlation with their characteristics, upon the structure and swelling, viscoelastic, and water decontamination properties of (nano)composite hydrogels. The experiments demonstrated that the nanocomposite hydrogel morphology was dictated by the way the filler particles dispersed in water. The equilibrium swelling degree (SDe) depended on both the pH of the environment and the filler nature. At pH 1.2, a slight crosslinking effect of the fillers was evidenced, increasing in the order Mt < Laponite < PS. At pH > pKaMAA (pH 5.4; 7.4; 9.5), the Laponite/Mt-containing hydrogels displayed a higher SDe as compared to the neat one, while at pH 7.4/9.5 the PS-filled hydrogels surprisingly displayed the highest SDe. Rheological measurements on as-prepared hydrogels showed that the filler addition improved the mechanical properties. After equilibrium swelling at pH 5.4, G’ and G” depended on the filler, the Laponite-reinforced hydrogels proving to be the strongest. The (nano)composite hydrogels synthesized displayed filler-dependent absorption properties of two cationic dyes used as model water pollutants, Laponite XLS-reinforced hydrogel demonstrating both the highest absorption rate and absorption capacity. Besides wastewater purification, the (nano)composite hydrogels described here may also find applications in the pharmaceutical field as devices for the controlled release of drugs. 相似文献
8.
We deposited BiFeO3 films on stainless steel substrates using a simple low-temperature wet-chemical route. Bismuth and iron nitrates were used as metal source and citric acid as chelating agent to prepare a water solution and deposit the film by dipping the steel substrate in the viscous solution. We have investigated the composition, crystallinity and structure of the BiFeO3 film on steel by X-ray diffraction, X-ray photoelectron spectroscopy, high resolution scanning electron microscopy, conventional and high resolution transmission electron microscopy, and energy dispersive spectroscopy techniques. The film deposited on the steel substrate has two sublayers: a very thin (about 100 nm) nanocrystalline layer, with crystallite size of few nanometers, and a thicker (below 1 μm) crystalline layer. 相似文献
9.
Jose M. Calderon Moreno Monica Popa Steliana Ivanescu Cora Vasilescu Silviu Iulian Drob Elena Ionela Neacsu Mihai V. Popa 《Metals and Materials International》2014,20(1):177-187
The corrosion behavior of a new, advanced Ti-20Zr alloy with α+β microstructure (determined by optical microscopy, XRD, and SEM) and very good mechanical properties (obtained from the stress-strain curve) is studied in this paper. The composition of the alloy native passive film was determined from a XPS analysis and the long-term corrosion resistance in undoped and doped states with 0.05M NaF artificial Carter-Brugirard saliva of different pH values, simulating the severe functional conditions of a dental implant, was analyzed by electrochemical methods. This alloy possesses an advantageous balance between good mechanical resistance and plasticity and Young’s modulus and exhibits more favorable electrochemical parameters and corrosion resistance than CP Ti due to its more resistant passive layer containing Ti2O3, TiO2, and ZrO2 protective oxides. After 1000 h of immersion in saliva, the protective properties of the alloy were enhanced due to the deposited surface layer that incorporated protective phosphates (shown by SEM and XPS). 相似文献
10.
Silviu Olariu Roman Kolesov Farit Vagizov Olga Kocharovskaya 《Journal of Modern Optics》2013,60(6):877-884
We study the changes in the shape of the Mössbauer spectrum for the 21.5?keV transition of 151Eu3+ nuclei in a CaF2 lattice, assuming that a population of the excited electronic state 5 D 0 is maintained by optical pumping. For a population of the excited state 5 D 0 of 10%, we determine the magnitude of the changes in the Mössbauer spectrum as 1.9% of the area of the unperturbed spectrum. 相似文献