Role of Zinc (Zn) in Human Reproduction: A Journey from Initial Spermatogenesis to Childbirth

Zinc (Zn), the second-most necessary trace element, is abundant in the human body. The human body lacks the capacity to store Zn; hence, the dietary intake of Zn is essential for various functions and metabolism. The uptake of Zn during its transport through the body is important for proper development of the three major accessory sex glands: the testis, epididymis, and prostate. It plays key roles in the initial stages of germ cell development and spermatogenesis, sperm cell development and maturation, ejaculation, liquefaction, the binding of spermatozoa and prostasomes, capacitation, and fertilization. The prostate releases more Zn into the seminal plasma during ejaculation, and it plays a significant role in sperm release and motility. During the maternal, labor, perinatal, and neonatal periods, the part of Zn is vital. The average dietary intake of Zn is in the range of 8–12 mg/day in developing countries during the maternal period. Globally, the dietary intake of Zn varies for pregnant and lactating mothers, but the average Zn intake is in the range of 9.6–11.2 mg/day. The absence of Zn and the consequences of this have been discussed using critical evidence. The events and functions of Zn related to successful fertilization have been summarized in detail. Briefly, our current review emphasizes the role of Zn at each stage of human reproduction, from the spermatogenesis process to childbirth. The role of Zn and its supplementation in in vitro fertilization (IVF) opens opportunities for future studies on reproductive biology.     

Calf massager: Intervention for body muscle discomfort during prolonged standing

Many occupations require workers to stand for long periods of time without proper interventions, which causes discomfort in the back and lower limbs. Therefore, this study aims to assess the effectiveness in alleviating body muscle discomfort during prolonged standing through the use of a calf massager. This study was conducted among male workers at a manufacturer with production line workers and the list was obtained from the HR Department and simple random sampling was done by number categorization. A total of 100 respondents (50 respondents for both the control and the experimental groups) participated in this study. The experiment took place in a room with a similar setup for the production line. Each respondent was requested to perform the simulated task for 2 hr. For the experimental group, the calf massager was turned on every 15 min. At every 15‐min interval after turning on the calf massager, respondents from both groups were required to evaluate their discomfort level on a Borg's scale CR‐10 questionnaire. The results showed that the level of body discomfort among respondents in the experimental group reduced (20–30%) compared with that of the control group. Multivariate analysis results revealed that the discomfort rating for the lower back, knees, thighs, calves, and feet was significantly lower (p < .05) among the experimental group compared with the control group. For lower body parts, the lower back region was statistically significant (p < .05) at the 90th, 105th, and 120th min; the thigh region was statistically significant (p < .05) at the 120th min; the knee region was statistically significant (p < .05) at the 105th and 120th min; the calf region was statistically significant (p < .05) at all minute intervals except the 15th and 45th min, while the feet region, was statistically significant at the 105th and 120th min. Therefore, this study indicates that calf massage treatment is capable of reducing body muscle discomfort during prolonged standing and highlights the significance of calf massage.     

Detection of dental abnormalities using SVM and PSVM

Landmarks needed for detecting dental abnormalities in cephalometric analysis were selected from the digital image, and the angle values needed for dental analysis were calculated and stored in a database which is used for developing training dataset. Principal component analysis was applied for dimension reduction to get the desired feature vectors which are trained and tested using support vector machine and proximal support vector machine classifier to detect the dental abnormalities, the performance of the classifiers were also compared.     

Probabilistic Health-lnformatics and Bioterrorism

In this article, new probabilistic health-informatics indices connecting probabilities： Pr（A）,Pr（B）,Pr（A IB） and P r（A ]B-） are discovered, where .4 and B denote respectively the ＂ability of a hospital to treat anthrax patients＂ and ＂whether a hospital drilled to be prepared to deal with an adverse bioterrorism＂. These probabilistic informatics are not seen in any textbooks or journal articles and yet, they are too valuable to be unnoticed to comprehend the hospitals＇ preparedness to treat anthrax patients in an outbreak of bioterrorism. A demonstration of this new probabilistic informatics is made in this article with the data in the U.S. Government＇s General Accounting Office＇s report GA0-03-924. Via this example, this article advocates the importance of the above mentioned probabilistic-informatics for health professionals to understand and act swiftly to deal with public health emergencies.     

An Efficient Lossless Telemetry Data Compression and Fault Analysis System Using 2SMLZ and CMOW-DLNN

Wireless Personal Communications - In this paper, the effect of perfect electric conductor (PEC) as a ground plane on antenna array is investigated. Vertical electric dipole which is of...     

Evaluation of potential anti‐cancer activity of cationic liposomal nanoformulated Lycopodium clavatum in colon cancer cells

Research dealing with early diagnosis and efficient treatment in colon cancer to improve patient''s survival is still under investigation. Chemotherapeutic agent result in high systemic toxicity due to their non‐specific actions on DNA repair and/or cell replication. Traditional medicine such as Lycopodium clavatum (LC) has been claimed to have therapeutic potentials against cancer. The present study focuses on targeted drug delivery of cationic liposomal nanoformulated LC (CL‐LC) in colon cancer cells (HCT15) and comparing the efficacy with an anti‐colon cancer drug, 7‐ethyl‐10‐hydroxy‐camptothecin (SN38) along with its nanoformulated form (CL‐SN38). The colloidal suspension of LC was made using thin film hydration method. The drugs were characterised using ultraviolet, dynamic light scattering, scanning electron microscopy, energy, dispersive X‐ray spectroscopy. In vitro drug release showed kinetics of 49 and 89% of SN38 and LC, whereas CL‐SN38 and CL‐LC showed 73 and 74% of sustained drug release, respectively. Studies on morphological changes, cell viability, cytotoxicity, apoptosis, cancer‐associated gene expression analysis of Bcl‐2, Bax, p53 by real‐time polymerase chain reaction and western blot analysis of Bad and p53 protein were performed. Nanoformulated LC significantly inhibited growth and increased the apoptosis of colon cancer cells indicating its potential anti‐cancer activity against colon cancer cells.Inspec keywords: cancer, biological organs, cellular biophysics, drug delivery systems, drugs, nanomedicine, genetics, DNA, molecular biophysics, biochemistry, lipid bilayers, toxicology, suspensions, colloids, light scattering, X‐ray chemical analysis, solvation, enzymes, nanostructured materialsOther keywords: energy dispersive X‐ray spectroscopy, in vitro drug release, morphological changes, cell viability, cytotoxicity, apoptosis, cancer‐associated gene expression analysis, Bcl‐2, Bax, real‐time polymerase chain reaction, western blot analysis, Bad protein, p53 protein, scanning electron microscopy, dynamic light scattering, ultraviolet scattering, thin film hydration method, colloidal suspension, nanoformulated form CL‐SN38, 7‐ethyl‐10‐hydroxy‐camptothecin, anticolon cancer drug, colon cancer cells HCT15, cationic liposomal nanoformulated LC, targeted drug delivery, therapeutic potentials, Lycopodium clavatum, traditional medicines, cell replication, DNA repair, nonspecific actions, high systemic toxicity, chemotherapeutic agents, patient survival, colon cancer treatment, colon cancer diagnosis, CL‐LC, potential anticancer activity     

Automatic classification of Tamil documents using vector space model and artificial neural network

Automatic text classification based on vector space model (VSM), artificial neural networks (ANN), K-nearest neighbor (KNN), Naives Bayes (NB) and support vector machine (SVM) have been applied on English language documents, and gained popularity among text mining and information retrieval (IR) researchers. This paper proposes the application of VSM and ANN for the classification of Tamil language documents. Tamil is morphologically rich Dravidian classical language. The development of internet led to an exponential increase in the amount of electronic documents not only in English but also other regional languages. The automatic classification of Tamil documents has not been explored in detail so far. In this paper, corpus is used to construct and test the VSM and ANN models. Methods of document representation, assigning weights that reflect the importance of each term are discussed. In a traditional word-matching based categorization system, the most popular document representation is VSM. This method needs a high dimensional space to represent the documents. The ANN classifier requires smaller number of features. The experimental results show that ANN model achieves 93.33% which is better than the performance of VSM which yields 90.33% on Tamil document classification.     

Critical modeling parameters identified for 3D CFD modeling of rectangular final settling tanks for New York City wastewater treatment plants

New York City Environmental Protection is in the process of incorporating biological nitrogen removal (BNR) in its wastewater treatment plants (WWTPs) which entails operating the aeration tanks with higher levels of mixed liquor suspended solids (MLSS) than a conventional activated sludge process. The objective of this paper is to discuss two of the important parameters introduced in the 3D CFD model that has been developed by the City College of New York (CCNY) group: (a) the development of the 'discrete particle' measurement technique to carry out the fractionation of the solids in the final settling tank (FST) which has critical implications in the prediction of the effluent quality; and (b) the modification of the floc aggregation (K(A)) and floc break-up (K(B)) coefficients that are found in Parker's flocculation equation (Parker et al. 1970, 1971) used in the CFD model. The dependence of these parameters on the predictions of the CFD model will be illustrated with simulation results on one of the FSTs at the 26th Ward WWTP in Brooklyn, NY.     

Modeling chip formation with grooved tools

A slip-line field model for orthogonal cutting with a tool containing a groove-like feature on its rake face is proposed. Primary contact at the tool-chip interface is taken to be plastic. Based on experimental observations, it is assumed that the chip flows into the groove, and is forced to curl by Coulomb friction contact with the groove back wall. Solutions obtained for different groove geometries, groove positions relative to the cutting edge, rake angles and tool-chip interface friction using the matrix operator method are presented and discussed. The calculated results are in general agreement with experimental observations. It is found that the model can be formulated so that it can be used to predict the cutting geometry for obstruction-type chip breakers as well.