全文获取类型
收费全文 | 1774篇 |
免费 | 78篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 20篇 |
综合类 | 3篇 |
化学工业 | 351篇 |
金属工艺 | 40篇 |
机械仪表 | 28篇 |
建筑科学 | 135篇 |
矿业工程 | 3篇 |
能源动力 | 44篇 |
轻工业 | 87篇 |
水利工程 | 7篇 |
石油天然气 | 3篇 |
武器工业 | 1篇 |
无线电 | 174篇 |
一般工业技术 | 307篇 |
冶金工业 | 305篇 |
原子能技术 | 14篇 |
自动化技术 | 331篇 |
出版年
2024年 | 5篇 |
2023年 | 21篇 |
2022年 | 26篇 |
2021年 | 66篇 |
2020年 | 32篇 |
2019年 | 31篇 |
2018年 | 49篇 |
2017年 | 39篇 |
2016年 | 58篇 |
2015年 | 46篇 |
2014年 | 80篇 |
2013年 | 87篇 |
2012年 | 86篇 |
2011年 | 112篇 |
2010年 | 79篇 |
2009年 | 88篇 |
2008年 | 74篇 |
2007年 | 81篇 |
2006年 | 61篇 |
2005年 | 57篇 |
2004年 | 47篇 |
2003年 | 23篇 |
2002年 | 31篇 |
2001年 | 32篇 |
2000年 | 22篇 |
1999年 | 35篇 |
1998年 | 89篇 |
1997年 | 61篇 |
1996年 | 46篇 |
1995年 | 31篇 |
1994年 | 21篇 |
1993年 | 28篇 |
1992年 | 15篇 |
1991年 | 13篇 |
1990年 | 14篇 |
1989年 | 6篇 |
1988年 | 10篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 10篇 |
1984年 | 8篇 |
1983年 | 13篇 |
1981年 | 14篇 |
1980年 | 5篇 |
1979年 | 10篇 |
1978年 | 6篇 |
1976年 | 12篇 |
1974年 | 8篇 |
1973年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有1853条查询结果,搜索用时 15 毫秒
1.
Landsiedel Justus Root Waleri Schramm Christian Menzel Alexander Witzleben Steffen Bechtold Thomas Pham Tung 《Nano Research》2020,13(10):2658-2664
Nano Research - Development of colored surfaces by formation of nano-structured aggregates is a widely used strategy in nature to color lightweight structures (e.g. butterflies) without the use of... 相似文献
2.
3.
Annika Jahn Anton Hoffmann Luisa Blaesing Fabian Kunde Martin Bertau Martina Bremer Steffen Fischer 《化学,工程师,技术》2020,92(11):1733-1740
The enzymatic conversion of lignins, possibly in combination with electrochemical oxidation, makes aromatics such as syringol, guaiacol, vanillin and catechol available in the qualities required by the fragrance industry. The lignins were obtained by soda digestion from wheat straw and Miscanthus, characterized and then converted with laccases. The overall yield amounted up to 9 wt % with a product spectrum confined to four substances. Catechol was the major product, with a fraction of ≈75 %. It can easily be isolated by extraction with acetone. 相似文献
4.
Steffen Vojacek Lukas Schulig Nathalie Wössner Norman Geist Prof. Dr. Walter Langel Prof. Dr. Manfred Jung Prof. Dr. Dennis Schade Prof. Dr. Andreas Link 《ChemMedChem》2019,14(8):853-864
Indoles are privileged structures in medicinal and bioorganic chemistry that are particularly well suited to serve as platforms for diversity. Among many other therapeutic areas, the indole scaffold has been used to design aromatic compounds useful to interfere with enzymes engaged in the regulation of substrate acylation status, such as sirtuins. However, the planarity of the indole ring is not necessarily optimal for all target enzymes, especially when functionalization with aromatic side chains is required. Replacement of flat scaffolds by nonplanar molecular cores dominated by sp3 hybridization is a common strategy to avoid the disadvantages associated with poor solubility and high promiscuity, while covering less-well-explored areas of chemical space. Thus, we synthesized fragment-like tetrahydroindoles suitable for fragment-based drug discovery as well as a well-characterized small library intended as multipurpose screening compounds. For proof of principle, these compounds were screened against sirtuins 1–3, enzymes known to be addressable by indoles. We found that 2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamides are potent and selective SIRT2 inhibitors. Compound 16 t displayed an IC50 value of 0.98 μm and could serve as exquisite starting point for hit-to-lead profiling. 相似文献
5.
The commercial success of the German Federal Ministry's materials research program “Mafto” (1985–1994) was recently evaluated to determine the effectiveness of the direct-funding model in supporting innovative industrial research. Based on the results of a questionnaire, where a 97% return rate was achieved, it was found that the results obtained in 27% of the projects have already been commercialized to some degree, for 26% of the projects a commercialization of the results is planned but has not yet taken place, and for 54% of the projects no commercialization is planned. This study included only projects where at least four years had elapsed since project completion. The reasons why scientifically and technically successfully projects were not commercialized were also surveyed. 相似文献
6.
A method for assessing health care technology that models the demand on the clinician's attention exerted by patients' data (diagnostic and therapeutic) can provide a means for simultaneously reducing the cost and improving the quality of health care. The attentional demand exerted by patients' data can be measured by the amount of uncertainty in the data. Uncertainty can be expressed mathematically by the concept of entropy in information theory. 相似文献
7.
Kollipara R.T. Arodzero A. Bashindzhagyan G. Brau J.E. Frey R. Gao D. Mason D. Sinev N. Strom D. Yang X. 《IEEE transactions on nuclear science》1995,42(2):92-101
The SSC GEM silicon Central Tracker design incorporated 18-cm long single-sided AC-coupled silicon microstrip ladders. Compared to the 12-cm long ladders considered in the preliminary stages of the tracker design, the 18-cm long ladders have the advantage of reduced cost, channel count and overall power consumption, and led to a simplified tracker assembly. However, such long ships also present the challenge of maintaining satisfactory performance. The increased capacitance and series resistance contribute to lower signal-to-noise ratios, longer time walk, higher power consumption per channel and increased probability of crosstalk to neighboring channels. In this paper, an accurate method to calculate the geometric capacitance of the AC-coupled microstrips is presented and the calculated results are compared with measurements, SPICE simulations are performed to predict the noise, the extent of interstrip capacitive coupling and the dispersion of the detector signal due to the finite series resistance of the metal strips and the long length of the detector. The influence of the preamplifier current and the shaping time on the signal and noise levels is also presented. The study concludes that the 18-cm long ladders can successfully satisfy the performance goals of the GEM silicon Central Tracker 相似文献
8.
Decision support for AIDS control programmes in Eastern Africa 总被引:1,自引:1,他引:0
Steffen Fleßa 《OR Spectrum》2003,25(2):265-291
The Acquired Immune Deficiency Syndrome (AIDS) constitutes the worst hazard to health care systems in Eastern Africa. Misallocation
of scarce resources of AIDS Control Programmes will unavoidably lead to additional infections and casualties. The following
paper discusses a system dynamics model which allows to assess the impact of different interventions on a pattern population
in Eastern Africa. It becomes obvious that short- and long-term consequences of these programmes differ significantly. The
optimal allocation of resources, therefore, is highly complex and calls for decision support systems to sustain AIDS control
programmes. 相似文献
9.
CM Tsai SH Hsiao CM Frey KT Chang RP Perng AF Gazdar BS Kramer 《Canadian Metallurgical Quarterly》1993,53(5):1079-1084
Both cisplatin (CDDP) and leucovorin (LV) have been shown to enhance cytotoxicity of 5-fluorouracil (FUra) against murine and human neoplasms by increasing intracellular reduced folate concentrations. We were interested in their use in a combination to inhibit non-small cell lung cancer (NSCLC) cell growth and therefore conducted an in vitro study to investigate the cytotoxic activities of combinations of CDDP plus FUra, with and without LV (20 microM), against seven NSCLC cell lines. A tetrazolium assay with application of the classical isobole method was used to test drug combinations. We found that LV enhanced FUra but not CDDP cytotoxicity and that the degree of enhancement was negatively correlated with the effect of FUra. There was an overall additive combination effect of CDDP plus FUra, although there may be synergy at higher effect levels. There was synergy to a combination of CDDP, FUra, and LV, presumably primarily related to the synergistic effects of adding LV to FUra. In summary, LV and CDDP enhanced FUra cytotoxicity in a complementary fashion and there was clear synergy of a combination of CDDP, FUra, and LV against a panel of NSCLC cell lines. Our in vitro results provide a rationale for controlled clinical studies of this three-drug regimen in patients with NSCLC. 相似文献
10.
The bit-error rate (BER) performance of new iterative decoding algorithms (e,g,, turbodecoding) is achieved at the expense of a computationally burdensome decoding procedure. We present a method called early detection that can be used to reduce the computational complexity of a variety of iterative decoders. Using a confidence criterion, some information symbols, state variables, and codeword symbols are detected early on during decoding. In this way, the computational complexity of further processing is reduced with a controllable increase in the BER. We present an easily implemented instance of this algorithm, called trellis splicing, that can be used with turbodecoding. For a simulated system of this type, we obtain a reduction in the computational complexity of up to a factor of four, relative to a turbodecoder that obtains the same increase in the BER by performing fewer iterations 相似文献