Most of the researches on error rate analysis of direct sequence spread spectrum (DSSS-CDMA) systems assume that the synchronization is perfect. However, in practice, the synchronization is often imperfect due to various effects of channel parameters such as noise and fading. The degree of imperfection further increases due to jamming attacks. The present study, therefore, derives new expressions to compute the probability of error in DSSS-CDMA systems under imperfect synchronisation. It is assumed that the channel is wideband and is subjected to various jamming attacks. A new parameter, called as probability of successful synchronization, was introduced which includes the effects of both the probability of false alarm and detection under fast and slow jammers. Monte Carlo simulations were conducted in MATLAB to establish the validity of the derived mathematical expressions.
The purpose of this paper is to present an algorithm developed for real-time estimation of skeletal muscle ischemia, based on parameters extracted from in vivo obtained electrical impedance spectra. A custom impedance spectrometer was used to acquire data sets: complex impedance spectra measured at 27 frequencies in the range of 100 Hz-1 MHz, and tissue pH. Twenty-nine in vivo animal studies on rabbit anterior tibialis muscle were performed to gather data on the behavior of tissue impedance during ischemia. An artificial neural network (ANN) was used to quantitatively describe the relationship between the parameters of complex tissue impedance spectra and tissue ischemia via pH. The ANN was trained on 1249, and tested on 946 ischemic tissue impedance data sets. A correlation of 94.5% and a standard deviation of 0.15 pH units was achieved between the ANN estimated pH and measured tissue pH values. 相似文献
Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure levels experienced by the general population and the ability of SiNPs to penetrate cells and tissues have raised concerns about possible toxic effects of this material. Although SiNPs are known to affect the function of the airway epithelium, the molecular targets of these particles remain largely unknown. Given that SiNPs interact with the plasma membrane of epithelial cells we hypothesized that they may affect the function of Transient Receptor Potential Vanilloid 4 (TRPV4), a cation-permeable channel that regulates epithelial barrier function. The main aims of this study were to evaluate the effects of SiNPs on the activation of TRPV4 and to determine whether these alter the positive modulatory action of this channel on the ciliary beat frequency in airway epithelial cells.
Results
Using fluorometric measurements of intracellular Ca2+ concentration ([Ca2+]i) we found that SiNPs inhibit activation of TRPV4 by the synthetic agonist GSK1016790A in cultured human airway epithelial cells 16HBE and in primary cultured mouse tracheobronchial epithelial cells. Inhibition of TRPV4 by SiNPs was confirmed in intracellular Ca2+ imaging and whole-cell patch-clamp experiments performed in HEK293T cells over-expressing this channel. In addition to these effects, SiNPs were found to induce a significant increase in basal [Ca2+]i, but in a TRPV4-independent manner. SiNPs enhanced the activation of the capsaicin receptor TRPV1, demonstrating that these particles have a specific inhibitory action on TRPV4 activation. Finally, we found that SiNPs abrogate the increase in ciliary beat frequency induced by TRPV4 activation in mouse airway epithelial cells.
Conclusions
Our results show that SiNPs inhibit TRPV4 activation, and that this effect may impair the positive modulatory action of the stimulation of this channel on the ciliary function in airway epithelial cells. These findings unveil the cation channel TRPV4 as a primary molecular target of SiNPs.
The paper presents a fluid-porous medium model, developed for stationary 2D predictions of fluidized bed. Dense phase is considered a fixed porous medium, while gas–particle interactions and bubbling phase are modeled regarding balance of friction forces between gas and particles. Like referent measurements, predictions of lateral jet injection into the bed suggest the jet penetration length is strongly affected by fluid velocity at the nozzle outlet, while influences of the nozzle vertical position and inclination angle are not significant. Also, the fluid velocity and the nozzle vertical position exert pronounced effects on mixing rate of components (fuel and oxidizer). 相似文献
Numerous studies associated with carbon-based materials have shown excellent results for the adsorption of important molecules. Bearing in mind that hydrogen is important as an energy source in this paper we investigated the adsorption properties of sumanene toward hydrogen molecules. We used a theoretical and computational approach in the framework of density functional theory. Frontier molecular orbitals, HOMO and LUMO, are visualized and molecular electrostatic potential surfaces are created, in order to locate adsorption places. We determined H2 adsorption binding energies, for which we obtained the applicable results. The adsorption properties of sumanene molecules toward hydrogen molecules were discussed through analysis of the density of states, partial density of states and overlap population density of states. Our results indicate that the sumanene can be very useful in the practical application for storage of hydrogen, which is the basis for its successful energy implementation. 相似文献