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排序方式: 共有187条查询结果,搜索用时 15 毫秒
1.
Nitsa Buaron Antonella Mangraviti Francesco Volpin Ann Liu Mariangela Pedone Eric Sankey Dina Aranovich Itay Adar Fausto J. Rodriguez Abraham Nyska Riki Goldbart Tamar Traitel Henry Brem Betty Tyler Joseph Kost 《Advanced functional materials》2021,31(44):2100643
Treating neuroinflammation-related injuries and disorders through manipulation of neuroinflammation functions is being heralded as a new therapeutic strategy. In this study, a novel pectic galactan (PG) polysaccharide based gene therapy approach is developed for targeting reactive gliosis in neuroinflammation. Galectin-3 (Gal-3) is a cell protein with a high affinity to β-galactoside sugars and is highly expressed in reactive gliosis. Since PG carries galactans, it can target reactive gliosis via specific carbohydrate interaction between galactan and Gal-3 on the cell membrane, and therefore can be utilized as a carrier for delivering genes to these cells. The carrier is synthesized by modifying quaternary ammonium groups on the PG. The resulting quaternized PG (QPG) is found to form complexes with plasmid DNA with a mean diameter of 100 nm and have the characteristics required for targeted gene therapy. The complexes efficiently condense large amounts of plasmid per particle and successfully bind to Gal-3. The in vivo study shows that the complexes are biocompatible and safe for administration and can selectively transfect reactive glial cells of an induced cortical lesion. The results confirm that this PG-based delivery system is a promising platform for targeting Gal-3 overexpressing neuroinflammation cells for treating neuroinflammation-related injuries and neurodegenerative diseases. 相似文献
2.
Danny Barash Tamar Schlick Moshe Israeli Ron Kimmel 《Journal of Mathematical Imaging and Vision》2003,19(1):33-48
Operator splitting is a powerful concept used in many diversed fields of applied mathematics for the design of effective numerical schemes. Following the success of the additive operator splitting (AOS) in performing an efficient nonlinear diffusion filtering on digital images, we analyze the possibility of using multiplicative operator splittings to process images from different perspectives.We start by examining the potential of using fractional step methods to design a multiplicative operator splitting as an alternative to AOS schemes. By means of a Strang splitting, we attempt to use numerical schemes that are known to be more accurate in linear diffusion processes and apply them on images. Initially we implement the Crank-Nicolson and DuFort-Frankel schemes to diffuse noisy signals in one dimension and devise a simple extrapolation that enables the Crank-Nicolson to be used with high accuracy on these signals. We then combine the Crank-Nicolson in 1D with various multiplicative operator splittings to process images. Based on these ideas we obtain some interesting results. However, from the practical standpoint, due to the computational expenses associated with these schemes and the questionable benefits in applying them to perform nonlinear diffusion filtering when using long timesteps, we conclude that AOS schemes are simple and efficient compared to these alternatives.We then examine the potential utility of using multiple timestep methods combined with AOS schemes, as means to expedite the diffusion process. These methods were developed for molecular dynamics applications and are used efficiently in biomolecular simulations. The idea is to split the forces exerted on atoms into different classes according to their behavior in time, and assign longer timesteps to nonlocal, slowly-varying forces such as the Coulomb and van der Waals interactions, whereas the local forces like bond and angle are treated with smaller timesteps. Multiple timestep integrators can be derived from the Trotter factorization, a decomposition that bears a strong resemblance to a Strang splitting. Both formulations decompose the time propagator into trilateral products to construct multiplicative operator splittings which are second order in time, with the possibility of extending the factorization to higher order expansions. While a Strang splitting is a decomposition across spatial dimensions, where each dimension is subsequently treated with a fractional step, the multiple timestep method is a decomposition across scales. Thus, multiple timestep methods are a realization of the multiplicative operator splitting idea. For certain nonlinear diffusion coefficients with favorable properties, we show that a simple multiple timestep method can improve the diffusion process. 相似文献
3.
We present results from computer simulations of the events immediately following the scattering of a dark matter particle off a nucleus in a crystal detector. Our simulations show that with NaF as the target, the recoil produces solitary waves that decay slowly, resulting in a narrow wake of phonons. The phonon wake allows a determination of direction of the nuclear recoil. 相似文献
4.
I Varsano B Volovitz Z Horev J Robinson Y Laks I Rosenbaum A Cohen N Eilam L Jaber C Fuchs J Amir 《Canadian Metallurgical Quarterly》1997,156(11):858-863
Two hundred and fifteen children aged 4 months 6 years with acute otitis media (AOM) were randomized to be treated either by a single i.m. injection of ceftriaxone, 50 mg/kg, with a second dose in the event of unsatisfactory response after 48 h or a history of recurrent AOM (109 patients) or amoxicillin clavulanate 12.5 mg tid (106 patients). The failure rate was similar in children treated by ceftriaxone and amoxicillin clavulanate, 4.6% and 4.7%, respectively (standard error for intergroup difference -2.87%, 95% confidence interval -5.62% to 5.87%). No significant differences between the groups were found in the dynamics of the resolution of the acute symptomatology, otoscopy findings, relapse rate at 30 days or tympanographic evidence of middle ear effusion at the scheduled visits on days 30, 60 and 90. Recurrence of AOM between days 31 and 90 was observed significantly in more children treated with amoxicillin clavulanate than with ceftriaxone--25 out of 84 (29.4%) versus 11 out of 81 (13.6%) (P = 0.012). Conclusion: Ceftriaxone injection(s) is as efficient at least as 10-day oral amoxicillin clavulanate for treatment of acute otitis media in children. Although not recommended as routine, ceftriaxone can be considered in the management of acute otitis media under special circumstances, particularly in cases when the ability to tolerate or absorb oral drugs is compromised, in children refusing or unable to take oral therapy or when the compliance is questionable. 相似文献
5.
Summary We propose hot-potato (or, deflection) packet routing algorithms on the two-dimensional mesh. The algorithms are strongly greedy in the sense that they attempt to send packets in good directions whenever possible. Furthermore, the routing operations are simple and independent of the time that has elapsed. The first algorithm gives the best evacuation time known for delivering all the packets to their destinations. A batch ofk packets with maximal source-to-destination distanced
max is delivered in 2(k-1)+d
max. The second algorithm improves this bound tok+d
max when all packets are destined to the same node. This also implies a new bound for the multitarget case, which is the first to take into account the number of in-edges of a node. The third algorithm is designed for routing permutations with source-to-destination distance at most three, in which case the algorithm terminates in at most seven steps. We also show a lower bound of five steps for this problem.
Ishai Ben-Aroya received the B.A. and M.Sc. in computer science from the Technion (Israel Institute of Technology). He is currently working with Microsoft Israel R&D group. His main interests include Routing Algorithms, Cryptography and Computer Security.
Tamar Eilam received the B.A. degree in Computer Science from the Technion IIL in 1995, and is currently studying towards her M.A. degree.
Assaf Schuster received his B.A., M.A. and Ph.D. degrees in Computer Science from the Hebrew University of Jerusalem (the last one in 1991). He is currently a lecturer at the Technion IIL. His main interests include Networks and Routing Algorithms, Parallel and Distributed Computation, Optical Computation and Communication, Dynamically Reconfiguring Networks, and Greedy Hot Potato Routing.This work was supported in part by the French-Israeli grant for cooperation in Computer Science, and by a grant from the Israeli Ministry of Science. An extended abstract appeared in proc. 2nd European Symposium on Algorithms, September 1994 相似文献
6.
Low‐income Hispanics are the most digitally underserved population in the U.S. This article examines the potential of community‐based participatory research approach to e‐health to decrease the disparities in access to technology and health information in low‐income Hispanic communities. To demonstrate this framework, we describe the process of designing a community‐based e‐health intervention to increase knowledge and parental self‐efficacy in coping with young children's mental health problems including mental health service utilization. Our model incorporates utilizing promotoras de salud (lay community health educators) and community media principles to create the content of e‐health interventions and train community members in using the technology. This case study illustrates the processes involved in using this approach, barriers for participatory e‐health interventions in bridging the Digital Divide, and lessons learned. 相似文献
7.
Some researchers claim that animations may hinder students’ meaningful learning or evoke misunderstandings. In order to examine these assertions, our study investigated the effect of animated movies on students’ learning outcomes and motivation to learn. Applying the quantitative methodology, two pre- and post-questionnaires were administered: Science thinking skills and Motivation to learn science. Students’ overall achievement in science was examined by their report card scores. The research population (N = 1335) was divided into experimental (N = 926) and control (N = 409) groups from 11 elementary schools. Findings indicated that the use of animated movies promoted students’ explanation ability and their understanding of scientific concepts. Findings also indicated that students who studied science with the use of animated movies developed higher motivation to learn science, in terms of: self-efficacy, interest and enjoyment, connection to daily life, and importance to their future, compared to the control students. Following the definition of multimedia, the students who study with the use of animated movies, applied all three learning styles: visual, auditory and kinesthetic. The use of multimedia and the fact that the students were engaged in exploring new concepts, that were relevant to their daily life experiences, can explain the positive results. 相似文献
8.
Frost Ram; Kugler Tamar; Deutsch Avital; Forster Kenneth I. 《Canadian Metallurgical Quarterly》2005,31(6):1293
Most models of visual word recognition in alphabetic orthographies assume that words are lexically organized according to orthographic similarity. Support for this is provided by form-priming experiments that demonstrate robust facilitation when primes and targets share similar sequences of letters. The authors examined form-orthographic priming effects in Hebrew, Arabic, and English. Hebrew and Arabic have an alphabetic writing system but a Semitic morphological structure. Hebrew morphemic units are composed of noncontiguous phonemic (and letter) sequences in a given word. Results demonstrate that form-priming effects in Hebrew or Arabic are unreliable, whereas morphological priming effects with minimal letter overlap are robust. Hebrew bilingual subjects, by contrast, showed robust form-priming effects with English material, suggesting that Semitic words are lexically organized by morphological rather than orthographic principles. The authors conclude that morphology can constrain lexical organization even in alphabetic orthographies and that visual processing of words is first determined by morphological characteristics. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
10.
Zamzam Awida Almog Bachar Hussam Saed Anton Gorodov Nathalie Ben-Califa Maria Ibrahim Albert Kolomansky Jennifer Ana Iden Liad Graniewitz Visacovsky Tamar Liron Sahar Hiram-Bab Michael Brines Yankel Gabet Drorit Neumann 《International journal of molecular sciences》2022,23(1)
The two erythropoietin (EPO) receptor forms mediate different cellular responses to erythropoietin. While hematopoiesis is mediated via the homodimeric EPO receptor (EPOR), tissue protection is conferred via a heteromer composed of EPOR and CD131. In the skeletal system, EPO stimulates osteoclast precursors and induces bone loss. However, the underlying molecular mechanisms are still elusive. Here, we evaluated the role of the heteromeric complex in bone metabolism in vivo and in vitro by using Cibinetide (CIB), a non-erythropoietic EPO analogue that exclusively binds the heteromeric receptor. CIB is administered either alone or in combination with EPO. One month of CIB treatment significantly increased the cortical (~5.8%) and trabecular (~5.2%) bone mineral density in C57BL/6J WT female mice. Similarly, administration of CIB for five consecutive days to female mice that concurrently received EPO on days one and four, reduced the number of osteoclast progenitors, defined by flow cytometry as Lin−CD11b−Ly6Chi CD115+, by 42.8% compared to treatment with EPO alone. In addition, CIB alone or in combination with EPO inhibited osteoclastogenesis in vitro. Our findings introduce CIB either as a stand-alone treatment, or in combination with EPO, as an appealing candidate for the treatment of the bone loss that accompanies EPO treatment. 相似文献