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排序方式: 共有362条查询结果,搜索用时 250 毫秒
1.
2.
Simonetta Pazzaglia Barbara Tanno Francesca Antonelli Paola Giardullo Gabriele Babini Prabal Subedi Omid Azimzadeh Zohaib N. Khan Kateryna Oleksenko Fabian Metzger Christine von Toerne Damien Traynor Dinesh Medipally Aidan D. Meade Munira Kadhim Fiona M. Lyng Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2021,22(8)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health. 相似文献
3.
We determined variation in both the concentration and composition of terpenoids in needles and wood within nine Scots pine (Pinus sylvestris) provenances. Seedlings of different provenances representing a 1200-km N–S transect from Estonia to northern Finland were cultivated in Suonenjoki nursery field, central Finland, for seven years. Growth of seedlings and the number of vertical resin ducts in wood were also determined. -Pinene and 3-carene were the major monoterpenes both in the needles and wood. The total monoterpene concentration was about five times higher in the needles than in the wood. A strong positive correlation was found between proportional quantities of several terpenes of the needles and wood, particularly for 3-carene, sabinene, and terpinolene. The needles contained both labdane-type and tricyclic resin acids, whereas the wood contained only tricyclic ones. The wood had a four times higher tricyclic resin acid concentration than the needles. The highest total monoterpene concentration in the needles and in the wood occurred in the most northern Muonio provenance and in the most southern Saaremaa provenance plants, respectively. The amount of high 3-carene genotype trees decreased among the northern provenances. The wood of the most northern Muonio provenance showed the lowest total resin acid concentration, but provenance did not affect total tricyclic resin acids in the needles. Korpilahti provenance trees from central Finland had the best growth in height. In addition, Korpilahti and Ruokolahti provenance trees showed largest radial growth of stem and smallest number of vertical resin ducts. The results suggest that especially the proportional quantity of 3-carene in the needles could be used in estimating the amount of this compound in the wood and vice versa. 相似文献
4.
Pekka Manninen Päivi Laakso Heikki Kallio 《Journal of the American Oil Chemists' Society》1995,72(9):1001-1008
This study demonstrates the usefulness of capillary supercritical fluid chromatography (SFC) for the characterization of triacylglycerols
of edible oils and fats. Triacylglycerols were separated according to the acyl carbon number and the degree of unsaturation
on a 25% cyanopropyl/25% phenyl/50% methylpolysiloxane stationary phase. Valuable information concerning the triacylglycerol
composition of berry oils was obtained, despite the overlapping of certain triacylglycerol peaks. Simultaneous analysis of
fat-soluble vitamins and triacylglycerols is not practical by capillary SFC with flame-ionization detection because of the
low concentration of naturally-occurring fat-soluble vitamins in edible oils. Therefore, higher loading of the sample, which
led to overloading of triacylglycerols, was required to get reasonable peaks for fat-soluble vitamins. The method was applied
to the characterization of triacylglycerols and tocopherols in sea buckthorn pulp and seed oil, and cloudberry seed oil without
any sample purification prior to SFC. In addition, the stationary phase proved useful for separating the more complex mixtures
of triacylglycerols found in milk fat and in fish oil. 相似文献
5.
Jeannette Aumo Johanna Lilja Päivi Mäki-Arvela Tapio Salmi Mats Sundell Hanna Vainio Dmitry Yu. Murzin 《Catalysis Letters》2002,84(3-4):219-224
A polymer-supported Pd catalyst was investigated in hydrogenation of citral (3,7-dimethyl-2,6-octadienal), which is a stereoisomer with an isolated and a conjugated double bond as well as a carbonyl group. The catalyst was a fibrous polymer-supported catalyst modified with functional groups and immobilized metals. A comparison of the polymer-supported catalyst with conventional catalysts was made. 相似文献
6.
J. M. Kyynäräinen J. P. Pekola K. Torizuka A. J. Manninen A. V. Babkin 《Journal of Low Temperature Physics》1991,82(5-6):325-367
We report on measurements of zero-sound attenuation in rotating and stationary3He-A and3He-B, in magnetic fields up to 350 mT. Strong and highly nonlinear rotation speed dependencies of sound amplitudes have been observed in both phases. The data gives information on vortex types and core sizes, although the analysis is not straightforward. The anomalous attenuation in3He-B at 200 mT near the AB transition, both in the stationary and in the rotating state, is interpreted to arise from the distortion of the energy gap of the B phase. Excess attenuation during the AB phase change was observed. Evidence for soft vortex cores in3He-B is presented. In addition, a critical velocity in the vortex free state, related to a textural transition, and the vortex creation times have been measured in3He-B. Furthermore, a metastable structure, possibly a new vortex state, has been observed in3He-B by rotating the sample through the A B transition. 相似文献
7.
Richard Haley Allen Armstrong Fergus Clancy Antti Manninen John Hook Henry Hall 《Journal of Low Temperature Physics》1995,101(3-4):787-792
We have investigated transverse continuous wave NMR in a geometry where the modes are influenced by susceptibility anisotropy. The helium sample is separated by mylar foils into layers 12 m thick perpendicular to the external dc magnetic field. In this geometryl is constrained to be parallel to the field andd switches from parallel to perpendicular to the field over a small range of field around the dipole unlocking field. The mode frequencies below this critical field yield a value for the susceptibility anisotropy. Above the critical field the expected negative frequency shift is observed, as well as a positive frequency shift due to bulk material and an unexpected signal close to the Larmor frequency. 相似文献
8.
Ye Liang Yan Susu Zhen Jialing Han Tian Ferdinando Hany Seppänen Tapio Alasaarela Esko 《Mobile Networks and Applications》2022,27(4):1688-1699
Mobile Networks and Applications - In recent years, physical violence detection has become a research hotspot in the area of human activity recognition. With the improvement and full coverage of... 相似文献
9.
Actions performed by a virtual character can be controlled with verbal commands such as ‘walk five steps forward’. Similar control of the motion style, meaning how the actions are performed, is complicated by the ambiguity of describing individual motions with phrases such as ‘aggressive walking’. In this paper, we present a method for controlling motion style with relative commands such as ‘do the same, but more sadly’. Based on acted example motions, comparative annotations, and a set of calculated motion features, relative styles can be defined as vectors in the feature space. We present a new method for creating these style vectors by finding out which features are essential for a style to be perceived and eliminating those that show only incidental correlations with the style. We show with a user study that our feature selection procedure is more accurate than earlier methods for creating style vectors, and that the style definitions generalize across different actors and annotators. We also present a tool enabling interactive control of parametric motion synthesis by verbal commands. As the control method is independent from the generation of motion, it can be applied to virtually any parametric synthesis method. 相似文献
10.
We introduce an efficient method for training the linear ranking support vector machine. The method combines cutting plane optimization with red-black tree based approach to subgradient calculations, and has O(ms + mlog (m)) time complexity, where m is the number of training examples, and s the average number of non-zero features per example. Best previously known training algorithms achieve the same efficiency only for restricted special cases, whereas the proposed approach allows any real valued utility scores in the training data. Experiments demonstrate the superior scalability of the proposed approach, when compared to the fastest existing RankSVM implementations. 相似文献