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1.
Yu-Hung Lee Ching-Fang Yu Ying-Chieh Yang Ji-Hong Hong Chi-Shiun Chiang 《International journal of molecular sciences》2021,22(4)
The low overall survival rate of patients with pancreatic cancer has driven research to seek a new therapeutic protocol. Radiotherapy (RT) is frequently an option in the neoadjuvant or palliative settings for pancreatic cancer treatment. This study explored the effect of RT protocols on the tumor microenvironment (TME) and their consequent impact on anti-programmed cell death ligand-1 (PD-L1) therapy. Using a murine orthotopic pancreatic tumor model, UN-KC-6141, RT-disturbed TME was examined by immunohistochemical staining. The results showed that ablative RT is more effective than fractionated RT at recruiting T cells. On the other hand, fractionated RT induces more myeloid-derived suppressor cell infiltration than ablative RT. The RT-disturbed TME presents a higher perfusion rate per vessel. The increase in vessel perfusion is associated with a higher amount of anti-PD-L1 antibody being delivered to the tumor. Animal survival is increased by anti-PD-L1 therapy after ablative RT, with 67% of treated animals surviving more than 30 days after tumor inoculation compared to a median survival time of 16.5 days for the control group. Splenocytes isolated from surviving animals were specifically cytotoxic for UN-KC-6141 cells. We conclude that the ablative RT-induced TME is more suited than conventional RT-induced TME to combination therapy with immune checkpoint blockade. 相似文献
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Yi‐Hung Chen Ching‐Yuan Chang Wei‐Ling Su Chun‐Yu Chiu Yue‐Hwa Yu Pen‐Chi Chiang Chiung‐Fen Chang Je‐Lueng Shie Chyow‐San Chiou Sally IM Chiang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(1):68-75
This study investigates the ozonation of CI Reactive Black 5 (RB5) by using the rotating packed bed (RPB) and completely stirred tank reactor (CSTR) as ozone contactors. The RPB, which provides high gravitational force by adjusting the rotational speed, was employed as a novel ozone contactor. The same ozone dosage was separately introduced into either the RPB or the CSTR for the investigation, while the experimental solution was continuously circulated within the apparatus consisting of the RPB and CSTR. The decolorization and mineralization efficiencies of RB5 in the course of ozonation are compared for these two methods. Moreover, the dissolved and off‐gas ozone concentrations were simultaneously monitored for the further analysis. As a result, the ozone mass transfer rate per unit volume of the RPB was significantly higher because of its higher mass transfer coefficient and gas–liquid concentration driving force. Furthermore, ozonation kinetics was found to be independent of the gravitational magnitude of an ozone gas–liquid contactor. Therefore, the results suggest employing RPBs as ozone‐contacting devices with the advantage of volume reduction. The experimental results, which can be used for further modeling of the ozonation process in the RPB, also show the requirement of correct design for the RPB. Consequently, the present study is useful for the understanding of practical application of RPBs. Copyright © 2004 Society of Chemical Industry 相似文献
5.
Fractal geometry is finding its application in the nondestructive evaluation (NDE) of corrosion by characterizing the corrosion surface with fractal dimensions. It was found that corrosion surfaces can be well described by multifractals. Two algorithms were used to obtain the fractal dimensions of a corroded aluminum alloy surface, one being box-counting and another being coherent light scattering. Fractal dimensions were related with the damage caused by corrosion and fatigue. 相似文献
6.
Gader P.D. Mohamed M. Jung-Hsien Chiang 《IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics》1997,27(1):158-164
An off-line handwritten word recognition system is described. Images of handwritten words are matched to lexicons of candidate strings. A word image is segmented into primitives. The best match between sequences of unions of primitives and a lexicon string is found using dynamic programming. Neural networks assign match scores between characters and segments. Two particularly unique features are that neural networks assign confidence that pairs of segments are compatible with character confidence assignments and that this confidence is integrated into the dynamic programming. Experimental results are provided on data from the U.S. Postal Service. 相似文献
7.
The introduction of multiple, independent production lines has helped many firms to increase their production flexibility, provide for redundancy when equipment breaks down, reduce idle time and labor costs, and achieve many other benefits. This paper introduces and formalizes the multiple U-line balancing problem. Optimal solution methodologies are provided for Type I (minimize the number of stations for a given cycle time), Type II (minimize the cycle time for a given number of stations), and cost-minimization line-balancing problems. A branch-and-bound algorithm is also developed for the situation in which equipment requirements are dependent on the line configuration and the task assignment to stations. Computational results indicate that the greatest benefit of exploiting multiple lines occurs for smaller cycle-time problems that require higher output. 相似文献
8.
John Chiang 《电子产品世界》2003,(18):44-45
闪存器技术于上世纪80年代中期面世,在不到20年的时间里,就出现了迅猛增长,其应用范围从个人电脑的引导代码存储一直到近期出现的PDA、数码相机和手机中的代码和数据存储。随着移动电子的持续增长,我们对在移动电子中获得成功应用的闪存器功能和优点进行一次回顾。闪存器的历史沿革“闪存(Flash)”这一名称,是源于该存储器件只需单步操作即能擦除其中所有内容的能力。军用装备很早就从这一能力中获益,军用装备都包含机密信息,一旦即将落入敌手,就应该迅速予以破坏。与EEPROM类似,Flash的数据存储也是通过向其晶体管栅区存入电荷来实现… 相似文献
9.
Films of electroactive polymers, such as polyaniline (PAN) in its emeraldine base form, and poly(3-alkylthiophene), poly(3-hexylthiophene) (P6TH), poly(3-octylthiophene) (P8TH), and poly(3-dodecylthiophene) (P12TH) can be readily functionalized via thermal or near ultraviolet-light-induced surface graft copolymerization with monomers of polyelectrolyte, polyampholyte and polymeric acids. The monomers used in the present work include dimethyl sulphate quaternized dimethylamino-ethylmethacrylate (DMAEM·C2H6SO4), 3-dimethyl(methacryloyloxyethyl)ammonium propane sulphonate (DMAPS), acrylic acid (AAc) and a sodium salt of styrene sulphonic acid (NaSS). The surface structures and compositions of the electroactive polymer films after functionalization via graft copolymerization were characterized by angle-resolved X-ray photoelectron spectroscopy. Graft copolymerization of poly(3-alkylthiophene) films, but not PAN films, with the hydrophilic monomers readily results in a stratified surface microstructure arising from the migration of the hydrophilic graft chains beneath a thin surface layer which is much richer in the substrate chains. On the other hand, graft copolymerization of PAN films with AAc and NaSS readily gives rise to a self-protonated (and thus conductive) surface structure. 相似文献
10.
N‐(4‐Acetoxyphenyl) maleimide (APMI) and three kinds of comonomers bearing a trimethylsilyl group were copolymerized at 60°C in the presence of azobisisobutyronitrile (AIBN) as an initiator in 1,4‐dioxane to obtain the three IP, IIP, and IIIP copolymers. These copolymers were removed from the acetoxy group in a transesterification process into new IVP, VP, and VIP copolymers with a pendant hydroxyl group. Two modified processes were adopted to prepare photoresists using these copolymers. The first process involved mixing the dissolution inhibitor, o‐nitrobenzyl cholate, with the new copolymers. Second, o‐nitrobenzyl cholate was introduced into the copolymers using 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) in dimethylformamide (DMF). The cyclic maleimide structure is responsible for the high thermal stability of these copolymers. After irradiation using deep–UV light and development with aqueous Na2CO3 (0.01 wt %), the developed patterns showed positive images and exhibited good adhesion to the silicon wafer without using any adhesion promoter. The resolution of these resists was at least 0.8 μm and an oxygen‐plasma etching rate was 1/5.3 to that of hard‐baked HPR‐204. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 2791–2798, 2002; DOI 10.1002/app.10255 相似文献