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排序方式: 共有100条查询结果,搜索用时 15 毫秒
1.
James E. Tyrrell Martyn G. Boutelle Alasdair J. Campbell 《Advanced functional materials》2021,31(1):2007086
Biological environments use ions in charge transport for information transmission. The properties of mixed electronic and ionic conductivity in organic materials make them ideal candidates to transduce physiological information into electronically processable signals. A device proven to be highly successful in measuring such information is the organic electrochemical transistor (OECT). Previous electrophysiological measurements performed using OECTs show superior signal-to-noise ratios than electrodes at low frequencies. Subsequent development has significantly improved critical performance parameters such as transconductance and response time. Here, interdigitated-electrode OECTs are fabricated on flexible substrates, with one such state-of-the-art device achieving a peak transconductance of 139 mS with a 138 µs response time. The devices are implemented into an array with interconnects suitable for micro-electrocorticographic application and eight architecture variations are compared. The two best-performing arrays are subject to the full electrophysiological spectrum using prerecorded signals. With frequency filtering, kHz-scale frequencies with 10 µV-scale voltages are resolved. This is supported by a novel quantification of the noise, which compares the gate voltage input and drain current output. These results demonstrate that high-performance OECTs can resolve the full electrophysiological spectrum and suggest that superior signal-to-noise ratios could be achieved in high frequency measurements of multiunit activity. 相似文献
2.
Canham R.O. Smith S.L. Tyrrell A.M. 《Vision, Image and Signal Processing, IEE Proceedings -》2005,152(6):741-749
Complex and highly distorted line drawings are produced by subjects attempting the Rey Complex Figure test, a clinical test of neuropsychological assessment. However, the marking scheme conventionally employed can be subjective and unreliable. In this paper, the first stages in automating this scoring system are investigated using a robust technique to locate a reduced set of scoring sections and a knowledge-based system that employs spatial metrics and fuzzy approximation techniques. Testing the technique using clinical data produced encouraging results that support the argument that this is a feasible approach for implementing a fully automated system, and that in its current state, can be immediately applied in a semi-automated system. 相似文献
3.
The role of a depressor factor, atrial natriuretic peptide, in the development of arterial hypertension in adolescents with pubertal hypothalamic syndrome was studied in 52 patients and 13 healthy males aged 13-24 years. The duration of disease was 2-11 years. Radioimmunological methods were used to measure plasma atrial natriuretic peptide, plasma renin activity, and serum aldosterone. Patients with borderline arterial hypertension were found to have a significant reduction in their atrial natriuretic peptide levels, and this correlated directly with the renin-aldosterone system, demonstrating insufficiency of the depressor system in patients with pubertal hypothalamic syndrome and the involvement of atrial natriuretic peptide in the development of arterial hypertension, along with disturbances in the functional relationship between atrial natriuretic peptide and the renin-aldosterone system. 相似文献
4.
Two experiments were conducted to compare methods of determining oxygen consumption by portal-drained viscera and to relate this consumption to total oxygen consumption by lactating dairy cows. Oxygen consumption was the product of portal blood flow (determined by dilution of dye infused into a mesenteric vein) and portal-arterial concentration differences of oxygen. In Experiment 1, portal-arterial concentrations of oxygen were determined in samples from three cows using equations based on blood pH, hemoglobin, partial pressure of carbon dioxide, and partial pressure of oxygen (method 1) or by direct oxygen determination with an oximeter (method 2). Overall, there were no differences in oxygen concentrations or oxygen consumption by portal-drained viscera between methods. In Experiment 2, oxygen consumption by portal-drained viscera (method 2) and total oxygen consumption were measured in two lactating cows. Oxygen consumption by portal-drained viscera accounted for 18% of total oxygen consumption. 相似文献
5.
6.
KL Margolis N Lurie PG McGovern M Tyrrell JS Slater 《Canadian Metallurgical Quarterly》1998,13(8):515-521
Active cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) was treated with an intraocular sustained-release ganciclovir implant. A total number of 19 implants were performed in 15 eyes of 9 AIDS patients. The intraocular sustained-release ganciclovir was effective in preventing reactivation of CMV retinitis in 15 of the 19 implants, ineffective in 3, and undetermined in 1. All ineffective cases had been resistant to ganciclovir therapy before the implants. Vision after the therapy was maintained at better than 0.5 except for one eye. There were no serious ocular complications caused by the therapy. Among 5 patients with unilateral CMV retinitis, 2 unaffected eyes developed CMV retinitis during this therapy. In addition, another patient developed presumed CMV infection in other systemic organs. Based on these data, the intraocular sustained-release ganciclovir implant was considered to be useful for the treatment of CMV retinitis in AIDS. 相似文献
7.
The relation of vergence effort to reports of visual fatigue following prolonged near work 总被引:3,自引:0,他引:3
Two experiments examined the link between vergence effort and subjective reports of visual fatigue following prolonged near work. In Experiment 1, dark vergence and reports of visual fatigue symptoms associated with computer use were measured in 104 persons. Dark vergence was significantly correlated with four of six symptoms of visual fatigue. In Experiment 2, 16 subjects who exhibited clear "Heuer effects" (systematic gaze-related changes in dark vergence) read from a video display terminal (VDT) at a distance of 20 cm for 60 min under two gaze elevation conditions: 20 deg above and 20 deg below a baseline gaze elevation. This manipulation was designed to vary the amount of vergence effort required to fixate the VDT. Results indicate a positive relation between vergence effort and visual fatigue both within and between subjects, and that prolonged near work leads to decreased vergence accuracy at far distances. Implications for VDT workstation design are discussed. 相似文献
8.
Omer Qadir Alex Lenz Gianluca Tempesti Jon Timmis Tony Pipe Andy Tyrrell 《Genetic Programming and Evolvable Machines》2014,15(3):245-274
The Protein Processor Associative Memory (PPAM) is a novel hardware architecture for a distributed, decentralised, robust and scalable, bidirectional, hetero-associative memory, that can adapt online to changes in the training data. The PPAM uses the location of data in memory to identify relationships and is therefore fundamentally different from traditional processing methods that tend to use arithmetic operations to perform computation. This paper presents the hardware architecture and details a sample digital logic implementation with an analysis of the implications of using existing techniques for such hardware architectures. It also presents the results of implementing the PPAM for a robotic application that involves learning the forward and inverse kinematics. The results show that, contrary to most other techniques, the PPAM benefits from higher dimensionality of data, and that quantisation intervals are crucial to the performance of the PPAM. 相似文献
9.
Erratum
Biomimetic Representation with Enzyme Genetic Programming 相似文献10.
The 2009 IEEE Congress on Evolutionary Computation (CEC 2009) was held at the Nova Conference Centre and Cinema, Trondheim, Norway during May 18th-21st, 2009. CEC 2009 was the eleventh occurrence of this major event in the evolutionary calendar. It was also the first time IEEE CEC has been held in Scandinavia. 相似文献