Superswelling Microneedle Arrays for Dermal Interstitial Fluid (Prote)Omics

The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been accelerated with -omics analyses but remains limited in ISF because of its time-consuming and complex extraction process. Here, the generation of microneedle (MN) patches made of superabsorbent acrylate-based hydrogels for the rapid sampling of dermal ISF is described to explore its proteome. In depth, iterative optimization allows the identification of novel acrylate-based compositions with the required chemical, mechanical, and biocompatibility properties allowing proteomic analysis of the extracted ISF for the first time after sampling with swelling MNs. The generated MN arrays show no cytotoxic effect, successfully cross the stratum corneum, and can collect up to 6 µL of dermal ISF in 10 min in vivo. Proteomics lead to the detection of 176 clinically relevant biomarkers in the collected samples validating the use of ISF as a relevant bodily fluid for disease monitoring and diagnostic. Importantly, it is discovered that extraction fingerprint is strongly dependent on the MNs chemistry, and thus specific biomarkers could be selectively extracted by tuning the composition of the patch, making the system versatile and specific.     

Workers’ rest allowance and smoothing of the workload in assembly lines

Ergonomic aspects have a crucial role in manual assembly systems. They impact on the workers’ health, final product quality and productivity. For these reasons, there is the necessity to integrate them into the assembly line balancing phase as, whereas, only time and cost variables are considered. In this study, human energy expenditures are considered as ergonomic aspects and we integrate them, for the first time, into the assembly line balancing problem type 2 through the rest allowance evaluation. We consider as an objective function the minimization of the smoothness index. Firstly, a new optimal method based on mixed integer linear programming and a new linearization methodology are proposed. Then, a heuristic approach is introduced. To complete the study, a computational experimentation is presented to validate the mathematical model and to compare the methodologies proposed in terms of computational time, complexity and solution. Additionally, we provide a detailed analysis of the impact that rest allowance evaluation can have on productivity comparing the results obtained, taking into account the rest allowance integration before, during and after the assembly balancing process.     

Analysis of the Single-Crystalline Silicon Photovoltaic (PV) Module Performances Under Low γ - Radiation from Radioactive Source

The present paper is about an experimental evaluation of the terrestrial silicon single-crystalline solar PV module behavior under low gamma radiation. The     

A self‐scalable load injection service

Load testing of applications is an important and costly activity for software provider companies. Classical solutions are very difficult to set up statically, and their cost is prohibitive in terms of both human and hardware resources. Virtualized cloud computing platforms provide new opportunities for stressing an application's scalability, by providing a large range of flexible and less expensive (pay‐per‐use model) computation units. On the basis of these advantages, load testing solutions could be provided on demand in the cloud. This paper describes a Benchmark‐as‐a‐Service solution that automatically scales the load injection platform and facilitates its setup according to load profiles. Our approach is based on: (i) virtualization of the benchmarking platform to create self‐scaling injectors; (ii) online calibration to characterize the injector's capacity and impact on the benched application; and (iii) a provisioning solution to appropriately scale the load injection platform ahead of time. We also report experiments on a benchmark illustrating the benefits of this system in terms of cost and resource reductions. Copyright © 2013 John Wiley & Sons, Ltd.     

A survey of parallel execution strategies for transitive closure and logic programs

An important feature of database technology of the nineties is the use of parallelism for speeding up the execution of complex queries. This technology is being tested in several experimental database architectures and a few commercial systems for conventional select-project-join queries. In particular, hash-based fragmentation is used to distribute data to disks under the control of different processors in order to perform selections and joins in parallel. With the development of new query languages, and in particular with the definition of transitive closure queries and of more general logic programming queries, the new dimension of recursion has been added to query processing. Recursive queries are complex; at the same time, their regular structure is particularly suited for parallel execution, and parallelism may give a high efficiency gain. We survey the approaches to parallel execution of recursive queries that have been presented in the recent literature. We observe that research on parallel execution of recursive queries is separated into two distinct subareas, one focused on the transitive closure of Relational Algebra expressions, the other one focused on optimization of more general Datalog queries. Though the subareas seem radically different because of the approach and formalism used, they have many common features. This is not surprising, because most typical Datalog queries can be solved by means of the transitive closure of simple algebraic expressions. We first analyze the relationship between the transitive closure of expressions in Relational Algebra and Datalog programs. We then review sequential methods for evaluating transitive closure, distinguishing iterative and direct methods. We address the parallelization of these methods, by discussing various forms of parallelization. Data fragmentation plays an important role in obtaining parallel execution; we describe hash-based and semantic fragmentation. Finally, we consider Datalog queries, and present general methods for parallel rule execution; we recognize the similarities between these methods and the methods reviewed previously, when the former are applied to linear Datalog queries. We also provide a quantitative analysis that shows the impact of the initial data distribution on the performance of methods. Recommended by: Patrick Valduriez     

The possibility of new high-transmission,high finesse,Perot-Fabry interferometers for far ir spectroscopy

Finesse as high as 260 and peak transmission close to 98% at frequencies around 30 cm^?1 are predicted at 10 K by coating the Perot-Fabry (PF) mirrors with a suitable thickness of High Tc (HTC) superconductor YBaCuO. In fact, Finesse will be limited by the lack of parallelism and the lack of perfect flatness of the mirrors to values around 100. These predictions are based upon phenomenological models for both the YBaCuO coating and the MgO support, i.e. from direct transmission measurements of MgO and YBaCuO in the Far IR, which had to be fitted by the models.     

MESOZOIC COLUMNS BELOW THE SEYCHELLES BANK, WESTERN INDIAN OCEAN

Exploratory drilling on the Seychelles Bank, in a sector west of outcrop granite on Mahé Island, has revealed the presence of substantial Mesozoic colums. Their thicness approaches 3,000m; and total Phanerozoic down to true basement probably exceeds 4,500m. Still greater depths are possible, not only in this drilled NW-most sector of the island arc of the Mascarene Ridge, but also elsewhere along the arc, whose total cross-latitudinal dimension is more than 2,000km. Volcanics, like those in the African borderlands, repeatedly enter the Phanerozoic column of the Seychelles. The young "basaltic basement" of geodynamic theory, consequently, cannot exist on the Seychelles Bank. The same negative may hold true for the whole arc of the Mascarene Ridge and for its marginal waters westward as far back as the African borderlands themsleves. In the domain of exploration, the prime parameter of sedimentary volume is acceptable along much of the Mascarene Ridge, for which reason wells drilled to true basement merit consideration in future drilling. Such wells in central and southern sectors might recover basement rocks whose petrology could offer a strong challenge to present concepts of paleogeography in the whole back-arc area of the western Indain Ocean.     

Evidence of High Vertical Wave-Number Behavior in a Continuously Stratified Reservoir: Boadella, Spain

High vertical wave-number modes clearly dominate the internal wave field during the stratification period in Boadella reservoir in northeast Spain. In this period, the extraction of hypolimnetic water, due to summer irrigation, brought the surface level down by 6 m in one month and the epilimnetic water progressively occupied the whole water column. The temperature profile, with the exception of a few meters at the surface layer, presented an almost constant temperature gradient of about 0.7°C/m. The period of the main vertical mode is 24 h with an amplitude of around 1 m. Thermistor chain records and meteorological data allow us to deduce that this mode is, at least, a third vertical mode forced by the wind, which normally has a typical periodicity of 24 h. However, when the wind changes direction from south to north, the circulation cells developed due to this forced nonstationary oscillation are destroyed. When this occurs, the Bulk Richardson number is Rib ～ 1. Similar vertical structures as a response to wind forcing should be expected in similar systems, although this has not been reported in the literature.