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Hristova Y Djambaski P Samuneva B Rangelova N Bogdanova S 《Journal of materials science. Materials in medicine》2008,19(2):805-811
A ternary melt-derived inorganic glass system (Igl) of composition corresponding to 62SiO2, 35Na2O, 3Al2O3 (wt.%) has been formulated and studied as a drug carrier. The [Al2O3/Na2O] ratio is less than one and the aluminium ion is a network former that retards the glass dissolution. The processing conditions
lead to a brittle, easily grinding, amorphous product. The Igl structure was proven by IR-spectroscopy, energy-dispersive
spectrometry, X-ray diffraction, scanning electron microscopy. A very important fact established is that the Igl corrosion
(dissolution) is pH-dependent. Inorganic glass system was transformed into model acetaminophen (APH) adsorbate (APH/Igla 1:1(w/w))
with mild experimental conditions and evaluated as a drug carrier. No interactions between Igl and APH during the processing
were proven. Besides, APH settles onto the glass surface as crystalline phase. A lower extent of corrosion, apparent solubility
and delayed in vitro APH release from the adsorbate in water and artificial gastric juice in comparison to the samples untreated
drug and APH/Iglm physical mixture were established. It is hypothesized that the glass decomposition products, formed into
contact with a solvent, initiate interactions with APH at the glass/solution interface. Similar behaviour of the Igl and its
drug adsorbates could be expected in gastro-intestinal tract. 相似文献
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Yoanna Choleva Mikkel Nrholm Susanne Pedersen Peter Mouritzen Poul E. Hiby Alex. T. Nielsen Sren Mller Mogens H. Jakobsen Lars Kongsbak 《Journal of The Association for Laboratory Automation》2001,6(4):92
Locked Nucleic Acid's or LNA are a new class of bicyclic DNA analogues that have a high affinity and specificity towards complementary nucleic acids. LNA containing oligonucleotides were used to develop a multiplex SNP genotyping assay based entirely on hybridization between capture probe and target. The approach incorporates a polymer microarray platform, photochemistry for immobilization of oligonucleotides onto microarrays, and a dedicated software tool to aid primer and capture probe design for highly multiplex genotyping. Furthermore, these technologies are combined in an integrated microfluidics platform for simple, highly multiplex and robust SNP genotyping. 相似文献
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Martínez-Díaz Yoanna Nicolás-Díaz Miguel Méndez-Vázquez Heydi Luevano Luis S. Chang Leonardo Gonzalez-Mendoza Miguel Sucar Luis Enrique 《Artificial Intelligence Review》2021,54(8):6201-6244
Artificial Intelligence Review - This paper studies the impact of lightweight face models on real applications. Lightweight architectures proposed for face recognition are analyzed and evaluated on... 相似文献
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