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排序方式: 共有237条查询结果,搜索用时 31 毫秒
1.
N. Satou A. Morikawa K. Ohmoto H. Urabe H. Shintani K. Wakasa M. Yamaki 《Journal of materials science. Materials in medicine》1996,7(12):749-752
This study was designed to evaluate the bacterial adhesion to five types of experimental composite-based resins and a commercial composite resin used as a control. Physicochemical surface characteristics of composite resins with and without an artificial saliva coating were measured. The relationship between the numbers of adhering cells (Streptococcus sanguis, S. mutans and S. sobrinus) and surface characteristics was analysed. The values of contact angles and the number of adhering cells were small with saliva coating. S. sanguis ATCC 10557 showed a positive correlation (r=0.835, p<0.05) with the contact angles of uncoated resins, whereas no relationship was observed for saliva-coated resins. With S. mutans Ingbritt the cell numbers adhering to resins correlated strongly (p<0.01) with the values of zeta potential of resins for either saliva coated or uncoated. Electrical repulsion forces had a strong contribution to adherence of cells such as S. mutans and S. sobrinus which show a high absolute zeta potential. 相似文献
2.
Masako Yudasaka Rie Kikuchi Takeo Matsui Yoshimasa Ohki Mark Baxendale Susumu Yoshimura Etsuro Ota 《Thin solid films》1996,280(1-2):117-123
Thin film formation of graphite by chemical vapor deposition using 2-methyl-1,2′-naphthyl ketone as a starting material was carried out on Ni film substrates. On Ni films directly deposited on quartz glass, the graphite films were obtained when the Ni film thickness was above 1 000 Å and above 5 000 Å at 700 °C and 1 000 °C, respectively. Depositions on thinner Ni film substrates comprise amorphous carbon (a-C) or graphite tubes which was owing to the thermal coagulation of the Ni film into droplets. On the other hand, graphite film was obtained on the Ni film with thickness 10 Å when a-C was inserted between the Ni film and the quartz glass. The coagulation of the Ni film is considered to be avoided by inserting a-C layer. 相似文献
3.
Using a newly devised model of dural sinus occlusion, we investigated the pathophysiology of venous haemorrhage as well as venous circulatory disturbance. The superior sagittal sinus (SSS) and diploic veins (DV) were occluded in 16 cats. Intracranial pressure (ICP), cerebral blood volume (CBV) and regional cerebral blood flow (rCBF) were measured for 12 hours after the occlusion. At the end of the experiment, cerebral water content was estimated. In another 8 cats additional occlusions of cortical veins were carried out. In both groups, the blood-brain barrier permeability was evaluated with Evans blue or horseradish peroxidase. The SSS and DV occlusion produced a significant increase in ICP and CBV concomitant with a significant decrease in rCBF. Cerebral water content also increased significantly. However, there was no transition of Evans blue and horseradish peroxidase through the cerebral vessels, and no haemorrhages could be observed. In contrast, the additional occlusion of cortical veins produced haemorrhagic infarctions with Evans blue extravasation in 6 out of the 8 cats. These data suggest that dural sinus occlusion may lead to an increase in CBV and cerebral water content resulting in intracranial hypertension and decreased rCBF. The brain oedema in this model seemed to be mainly hydrostatic oedema, and might also be contributed by cytotoxic oedema. The additional occlusion of cortical veins might be essential in the development of haemorrhage in this model, and the blood-brain barrier was also disrupted in these areas. 相似文献
4.
Dr. Daisuke Okuno Dr. Noriho Sakamoto Dr. Mohammed S. O. Tagod Yoshiko Akiyama Dr. Sakiko Moriyama Dr. Takuto Miyamura Dr. Atsuko Hara Dr. Takashi Kido Dr. Hiroshi Ishimoto Prof. Yuji Ishimatsu Prof. Takashi Tanaka Prof. Jun Ishihara Prof. Kohsuke Takeda Prof. Yoshimasa Tanaka Prof. Hiroshi Mukae 《ChemMedChem》2021,16(16):2515-2523
Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis. 相似文献
5.
Imoto Taiji; Ueda Tadashi; Tamura Tomohiro; Isakari Yoshimasa; Abe Yoshito; Inoue Makoto; Miki Takeyoshi; Kawano Keiichi; Yamada Hidenori 《Protein engineering, design & selection : PEDS》1994,7(6):743-748
Mutations around His15 which lie far away from the active site,stimulated glycol chitin activity of lysozyme at physiologicaltemperature. Del-Argl4Hisl5 lysozyme, a mutant lysozyme whoseArgl4 and Hisl5 were deleted together, and has the highest activityamong these mutant lysozymes, had a similar binding abilityto a trimer of N-acetyl-glucosamine, a substrate analogue, relativeto native lysozyme. This suggests that the increased activitywas due to an increased kcat in the catalysis reaction. TheH-D exchange rate of the N-1 proton in the Trp63 which is locatedin the active site cleft, was enhanced in the Del-Argl4Hisl5lysozyme, while 2-D proton NMR analysis revealed no conformationalchange around Trp63. We conclude that some sort of fluctuationat the active site might be required for the manifestation ofactivity. This theory is supported by the finding that the Del-Argl4Hisl5lysozyme showed a shift in temperature dependency of activityto lower temperatures compared with that of native lysozyme. 相似文献
6.
Toshihide Miyagi Norihiro Abe Yoshimasa Kinoshita Tatsushi Tokuyasu Hirokazu Taki Shoujie He 《Artificial Life and Robotics》2009,14(2):237-241
In this article, a system is proposed for a simulated operation which would help a trainee surgeon to perform a medical operation
to ensure that a cerebral aneurysm does not burst. The physician will have acquired empirical medical technologies from operations
in traditional clinical teaching. However, there is a problem with safety and the burden to the patient. Therefore, recently
a new training approach for a simulated medical operation using virtual reality has been explored. With the aim of developing
a simulated system for a medical operation for a cerebral aneurysm, we considered the necessary functions such as detecting
the brain aneurysm that is the target of the operation, and searching for a suitable blood vessel to make a plan for the operation. 相似文献
7.
Yoshimasa A. Ono Jun'ichiro Hara Katsuhiko Nagai Kiyoshi Kawamura 《Journal of Low Temperature Physics》1977,27(3-4):513-536
The shear viscosity (T) in the Balian-Werthamer (BW) state of superfluid
3
He is calculated variationally throughout the region 0t 1(t=T/T
c) from the transport equation for Bogoliubov quasiparticles. Coherence factors are treated exactly in the calculation of the collision integral. The numerical result for
=s= s(T)/n(Tc) agree very well with experiment in the range 0.8t1.0. Analytic expressions
= 0.577 (1–1.0008t) and
=1–(23/64) [=(T)/k
B
T] are obtained in the low-temperature region and in the vicinity ofT
c, respectively. From the numerical analysis it is shown that the latter equation is valid only in the temperature range 0.9997t1.0.Supported by the Research Institute for Fundamental Physics, Kyoto University. 相似文献
8.
Hiroyuki Hirakata Yoshimasa Takahashi Shohei Matsumoto Takayuki Kitamura 《Engineering Fracture Mechanics》2006,73(17):2698-2709
In order to examine the mechanics of crack initiation at the free interface edge of a microcomponent on a substrate, delamination tests are carried out for two specimen shapes of Cr microdots on a SiO2 substrate. The microdots of the first specimen are shaped like the frustum of a round cone. The Cr microdots are successfully delaminated from the SiO2 substrate in a brittle manner and the critical load is measured by atomic force microscopy (AFM) with a lateral loading apparatus. Stress analysis reveals that a singular stress field exists near the interface edge and the strength for the crack initiation is governed by the intensified normal stress field. The critical stress intensity parameter is evaluated as KσC ≈ 0.24 MPa m0.39. Similar delamination tests are conducted for microdots shaped like the frustum of an oval cone. The stress distributions at the crack initiation of this specimen shape show a higher normal stress than the first specimen shape in the region near the interface edge of about x < 40 nm, while it is lower in the region of about x > 50 nm (x: distance from the edge). This suggests a limitation of conventional fracture mechanics: namely, the crack initiation in these specimens is not uniquely governed by the intensity of the singular field. It is found that the delamination crack is initiated when the averaged stress σya in the region of 90-130 nm reaches 190-270 MPa, regardless of the specimen shape. This indicates that the dominant stress region of crack initiation is roughly estimated as 90-130 nm and the criterion is given in terms of the averaged stress in the region. 相似文献
9.
10.