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Minds and Machines - The danger of human operators devolving responsibility to machines and failing to detect cases where they fail has been recognised for many years by industrial psychologists... 相似文献
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Metabolic studies on diftalone (I), a new non-steroidal antiinflammatory agent, demonstated that 7-hydroxydiftalone beta-glucuronide (V) is the main urinary metabolite. The isolation of (V) from the urine of a dog treated with 14C-diftalone was performed by liquid-liquid partition after precolation through Amberlite XAD-2 and IRC-50 (H+). All the steps were followed by radio-detection and by thin layer radio-chromatography. Compound (V) was characterized mainly by mass spectrometry after esterification with diazomethane and silylation with BSA. 相似文献
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A Kamoun M Daudon N Kabaar R Dhaoui S Ben Ammar A Zghal L Zerilli B Chaouachi C Belkahia R Lakhoua 《Canadian Metallurgical Quarterly》1995,5(6):942-945
Fifty-five Tunisian children with urinary stones, between the ages of 8 months and 15 years, underwent morphological and infrared spectrophotometric analysis of their stones. This study provides an approach to the aetiological profile of urinary stones in Tunisian children. The nucleus of the stones was composed of acidic ammonium urate in 48% of cases with a morphology suggestive of phosphorus deficiency associated with a history of diarrhoea. In 24% of cases, the nucleus contained struvite indicating the presence of urinary tract infection by urease-positive bacteria. The main growth factors of urinary stones were hyperoxaluria and urinary tract infection. In 5 cases, the stones were due to a hereditary lithogenic metabolic disease : cystinuria in 1 case and primary hyperoxaluria in 4 cases. 相似文献
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A Di Giorgio C Botti P Mingazzini P Arnone A Canavese C Cardini S Consolo M Zerilli A Alessandrina 《Canadian Metallurgical Quarterly》1994,65(1):99-104
A new model of 4-alkyl-1-arylpiperazines containing a terminal dihydronaphthalene fragment on the alkyl chain was synthesized in order to have mixed serotonergic and dopaminergic activity and to pursue the recent alternative approaches to the discovery of novel antipsychotic and anxiolytic agents. Title compounds were evaluated for in vitro activity on dopamine D-2 and serotonin 5-HT1A and 5-HT2 receptors by radioreceptor binding assays. They show high nanomolar affinity for 5-HT1A, moderate affinity for D-2, and low affinity for 5-HT2 receptors, and in particular, two compounds, 4-[3-(1,2-dihydro-6-methoxynaphthalen-4-yl)-n-propyl]-1-(2- methoxyphenyl)piperazine (8) and 4-[3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl]-1-(2- pyridyl)piperazine (15), show values (nM) of IC50 = 2.0 and 1.4 for 5-HT1A and IC50 = 90.6 and 119.3 for D-2, respectively. Some in vivo behavioral studies show compound 8 to be an antagonist on 5-HT1A receptors. These first findings place the new arylpiperazines on the same level as that of the azaspirone class, e.g., 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)-n-butyl]piperazine (NAN-190) and buspirone. 相似文献
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Frank J. Zerilli 《Metallurgical and Materials Transactions A》2004,35(9):2547-2555
A review of constitutive models based on the mechanics of dislocation motion is presented, with focus on the models of Zerilli
and Armstrong and the critical influence of Armstrong on their development. The models were intended to be as simple as possible
while still reproducing the behavior of real metals. The key feature of these models is their basis in the thermal activation
theory propounded by Eyring in the 1930’s. The motion of dislocations is governed by thermal activation over potential barriers
produced by obstacles, which may be the crystal lattice itself or other dislocations or defects. Typically, in bcc metals,
the dislocation-lattice interaction is predominant, while in fcc metals, the dislocation-dislocation interaction is the most
significant. When the dislocation-lattice interaction is predominant, the yield stress is temperature and strain rate sensitive,
with essentially athermal strain hardening. When the dislocation-dislocation interaction is predominant, the yield stress
is athermal, with a large temperature and rate sensitive strain hardening. In both cases, a significant part of the athermal
stress is accounted for by grain size effects, and, in some materials, by the effects of deformation twinning. In addition,
some simple strain hardening models are described, starting from a differential equation describing creation and annihilation
of mobile dislocations. Finally, an application of thermal activation theory to polymeric materials is described.
This article is based on a presentation given in the symposium “Dynamic Deformation: Constitutive Modeling, Grain Size, and
Other Effects: In Honor of Prof. Ronald W. Armstrong,” March 2–6, 2003, at the 2003 TMS/ASM Annual Meeting, San Diego, California,
under the auspices of the TMS/ASM Joint Mechanical Behavior of Materials Committee. 相似文献
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