Al-10Mg型固溶合金自然时效稳定性研究

测定了ZL30 5合金自然时效 33年的力学性能变化 ,观察了晶界的析出相 ,研究了组织和性能的关系 ,从而确定了ZL30 5合金具有长期自然时效稳定性。     

Single-longitudinal-mode fiber ring laser employing an equivalent phase-shifted fiber Bragg grating

A novel single-longitudinal-mode (SLM) fiber ring laser that incorporates an equivalent phase-shifted fiber Bragg grating acting as an ultra-narrow bandpass filter in the laser cavity is proposed. The equivalent phase-shifted fiber Bragg grating has an ultra-narrow transmission bandwidth which ensures an SLM lasing. Stable SLM operation without mode hopping is demonstrated.     

套管固井质量问题及对策分析

从油田现场反应的情况出发，对调整井固井，尾管固井，大位移井套管固井和其他固井的质量问题进行了分析，针对各种问题产生的原因，提出了相应换解决办法。     

天铁炼钢厂板坯漏钢原因分析及预防

针对天铁板坯连铸机一年多来发生的漏钢事故，分析了产生的原因，提出了预防改进的措施，对今后的生产有很好的指导意义。     

Design,Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds′ cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure–activity relationships (SAR) are discussed. 2-deoxy-d -glucoside 5 k displayed the most potent antiproliferative activities against HepG2 cells with an IC₅₀ value of 1.5 μM. Further pharmacological experiments on compound 5 k on HepG2 cells revealed that it could cause morphological changes and cell-cycle arrest at the G0/G1 phase and then induced the apoptosis, which might be associated with the enhanced expression of high-mobility group Box 1 (HMGB1). Taken together, these findings prove that the neoglycosylation of steroids could be a promising strategy for the discovery of potential antiproliferative agents.     

A “Three-in-One” Multifunctional Probe for Bcl-2/Mcl-1 Profiling and Visualizing in Situ

Bcl-2 and Mcl-1, the two arms of the anti-apoptotic Bcl-2 family proteins, have been identified as key regulators of apoptosis and effective therapeutic targets of cancer. However, no small-molecular probe is capable of profiling and visualizing both Bcl-2 and Mcl-1 simultaneously in situ. Herein, we report a multifunctional molecular probe (BnN₃-OPD-Alk) by a “three-in-one” molecular designing strategy, which integrated the Bcl-2/Mcl-1 binding ligand, fluorescent reporter group and photoreactive group azido into the same scaffold. BnN₃-OPD-Alk exhibited sub-micromolar affinities to Bcl-2/Mcl-1 and bright green self-fluorescence. It was then successfully applied for Bcl-2/Mcl-1 labeling, capturing, enriching, and bioimaging both in vitro and in cells. This strategy could facilitate the precise early diagnosis and effective therapy of dual Bcl-2/Mcl-1-related diseases.     

北美和欧洲消失模铸造发展现状

2001-2002年美国和德国相继召开了3个有关消失模铸造研讨会，共交流45篇报告。报告归纳出北美和欧洲在消失模铸造研究上有3大热点：开展消除铝合金消失模铸造缺陷的研究；完善发泡模具及白区制模技术；探索消失模铸造模拟和快速原型制造技术。介绍了国外消失模铸造企业现状，指出我国消失模铸造与世界先进消失模技术的3大差距。     

Sparse Localized Decomposition of Deformation Gradients

Sparse localized decomposition is a useful technique to extract meaningful deformation components out of a training set of mesh data. However, existing methods cannot capture large rotational motion in the given mesh dataset. In this paper we present a new decomposition technique based on deformation gradients. Given a mesh dataset, the deformation gradient field is extracted, and decomposed into two groups: rotation field and stretching field, through polar decomposition. These two groups of deformation information are further processed through the sparse localized decomposition into the desired components. These sparse localized components can be linearly combined to form a meaningful deformation gradient field, and can be used to reconstruct the mesh through a least squares optimization step. Our experiments show that the proposed method addresses the rotation problem associated with traditional deformation decomposition techniques, making it suitable to handle not only stretched deformations, but also articulated motions that involve large rotations.     

基于粒子群优化的多弧离子镀膜 温度控制模糊系统

分析了多弧离子镀膜层沉积过程的特点,提出一种基于粒子群优化的PID插值自适应控制与模糊控制相结合的自适应控制算法,并用MATLAB仿真软件对控制算法进行仿真。结果表明,该控制方案简单、有效,能满足多弧离子镀膜温度控制要求。