快速灵敏的LC-MS/MS法测定人血浆中阿莫西林并应用于两种制剂的一致性评价

目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度，并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪，以MRM模式测定阿莫西林（m/z 366.00/114.00）的浓度，d4-阿莫西林作内标（m/z 370.10/114.05），离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18（2.1×50 mm，1.7 μm），梯度洗脱。血浆样本加入内标，经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证，其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求，并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏，适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测，两种制剂生物等效。     

栲胶法变换气脱硫工艺

介绍了栲胶法脱硫的原理，工艺流程及规整填料在脱硫塔中的应用。     

大面积1.54μm波长测距用InGaAs雪崩光电二极管

设计并研制成功适合人的眼睛安全测距应用的ＩｎＧａＡｓ雪崩光电二极管（ＡＰＤ）。器件直径为２００μｍ，工作在２１℃，１５４０ｎｍ波长时响应为０．６４Ａ／Ｗ，典型暗电流和噪声因子分别为３０ｎＡ和６．５。介绍了该器件的工作原理，设计和制作工艺。     

On the behavior of microstructures with multiple length scales

The current study aims to provide fundamental insight into the behavior of microstructures containing grain sizes that span multiple length scales. A commercial 5083 Al alloy was selected as the material of interest to facilitate comparison with recently published data. The materials studied here were prepared via the thermal consolidation of powders that were cryomilled for different times (i.e., 0, 2, 4, and 8 hours). Following consolidation, the resultant microstructure was characterized by an equiaxed grain morphology with a size distribution centered around 200∼300 nm. Dispersed among the 200- to 300-nm grains were coarse-grained regions or ligaments with a grain size ranging from 600 nm to 2 μm. The occurrence of coarse-grained regions is rationalized on the basis of recrystallization or subgrain coarsening, whereas the occurrence of equiaxed fine regions is proposed to be a result of continuous grain growth. Two types of microstructures were selected for study, containing coarse-grained volumes of approximately 28 pct and 43 pct that corresponded to an ultimate tensile strength (UTS) of 566 MPa and 535 MPa, and a fracture strain of 3.2 pct and 3.5 pct, respectively. The observed ductility and the relevant toughening mechanisms were discussed in light of the presence of multiple length scales.     

高层天台移动通信天线电磁辐射影响水平探讨

移动通信基站在高层建筑天台架设的定向天线，对周围环境的电磁辐射影响水平的监测进行分析，探讨高层建筑天台电磁辐射环境的污染防治对策。     

催柴加氢装置分馏系统空冷改造方案的探讨

对催柴加氢装置分馏系统空冷存在的问题进行了剖析,认为两塔回流温度不能同时满足工艺需要的主要原因是2台空冷共用风机造成的,并对改造方案进行了比较。     

折反光学系统最佳红外像面位置的研究

较深入地研究了折反光学系统的红外像面,为确定实际的红外像面提出了一个新方法—计算从可见光边缘无色的弥散圆到红外最佳像面的距离。实践证明,这是确定这类光学系统最佳像面的一个方便、可靠的方法。     

医院排队叫号系统应用现状综述

为了减少患者在医院的滞留量和高效服务于患者,很多医院都采用了排队叫号系统。医院排队叫号系统产品繁多,医院的实施机制也各不相同,因此分析了目前医院排队叫号系统的应用现状,以及硬、软件实施情况,以求发现系统的主要组成部分和可更新、扩展部分。结合挂号方式、就诊流程优化和物联网技术分析了医院排队叫号系统的发展趋势,这对今后其他领域排队叫号系统的研究有参考意义。     

Fuzzy local maximal marginal embedding for feature extraction

In graph-based linear dimensionality reduction algorithms, it is crucial to construct a neighbor graph that can correctly reflect the relationship between samples. This paper presents an improved algorithm called fuzzy local maximal marginal embedding (FLMME) for linear dimensionality reduction. Significantly differing from the existing graph-based algorithms is that two novel fuzzy gradual graphs are constructed in FLMME, which help to pull the near neighbor samples in same class nearer and nearer and repel the far neighbor samples of margin between different classes farther and farther when they are projected to feature subspace. Through the fuzzy gradual graphs, FLMME algorithm has lower sensitivities to the sample variations caused by varying illumination, expression, viewing conditions and shapes. The proposed FLMME algorithm is evaluated through experiments by using the WINE database, the Yale and ORL face image databases and the USPS handwriting digital databases. The results show that the FLMME outperforms PCA, LDA, LPP and local maximal marginal embedding.     

用于界面局放研究的正交电场测试单元

界面缺陷引发的局部放电是导致界面击穿的主要原因之一,而电缆附件界面局放的引发、演变规律尚不明确.本研究首先仿真分析了实际电缆附件界面电场分布,并依据电场计算结果采用内置电极法设计制作了界面测试单元,最后对设计的界面单元进行局部放电引发试验.结果 表明:该界面测试单元与实际电缆附件界面电场分布类似,使用该界面单元获得的局部放电发展规律与实际电缆附件的局部放电发展规律相同.该界面单元能够有效模拟实际电缆附件界面电场,同时避免了向测试界面内引入金属电极,可以用于电缆附件界面局部放电引发、演变规律等方面的研究.