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1.
Kimoto T. Kosugi H. Suda J. Kanzaki Y. Matsunami H. 《Electron Devices, IEEE Transactions on》2005,52(1):112-117
Design and fabrication of lateral SiC reduced surface field (RESURF) MOSFETs have been investigated. The doping concentration (dose) of the RESURF and lightly doped drain regions has been optimized to reduce the electric field crowding at the drain edge or in the gate oxide by using device simulation. The optimum oxidation condition depends on the polytype: N/sub 2/O oxidation at 1300/spl deg/C seems to be suitable for 4H-SiC, and dry O/sub 2/ oxidation at 1250/spl deg/C for 6H-SiC. The average inversion-channel mobility is 22, 78, and 68 cm/sup 2//Vs for 4H-SiC(0001), (112~0), and 6H-SiC(0001) MOSFETs, respectively. RESURF MOSFETs have been fabricated on 10-/spl mu/m-thick p-type 4H-SiC(0001), (112~0), and 6H-SiC(0001) epilayers with an acceptor concentration of 1/spl times/10/sup 16/ cm/sup -3/. A 6H-SiC(0001) RESURF MOSFET with a 3-/spl mu/m channel length exhibits a high breakdown voltage of 1620 V and an on-resistance of 234 m/spl Omega//spl middot/cm/sup 2/. A 4H-SiC(112~0) RESURF MOSFET shows the characteristics of 1230 V-138 m/spl Omega//spl middot/cm/sup 2/. 相似文献
2.
M Mitani Y Yokoyama S Ichikawa H Sawada T Matsumoto K Fujimori M Kosugi 《Canadian Metallurgical Quarterly》1994,9(6):355-361
The chemiluminescence of the Cypridina luciferin analogue, 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin++ +-3-one (MCLA) was observed at 462 nm in the presence of horseradish peroxidase (HRP) and the total spectrum of light emitted was found to depend linearly on HRP concentration. Methods for the determination of HRP concentration using the chemiluminescence was investigated. HRP could be detected in the range from 100 pmol/L to 100 nmol/L under the optimum condition, H2O2 (10 mmol/L) and MCLA (10 mumol/L) at pH 5.8. 相似文献
3.
Yoshitsugu Kosugi Tsutomu Kunieda Naoki Azuma 《Journal of the American Oil Chemists' Society》1994,71(4):445-448
Rice bran oil containing 30–50% free fatty acid was continually converted to an oil containing more than 75% of triacylglycerol
(TG) by means of immobilized lipase. The reaction was carried out at 60°C for 24 h with dehydration and reactant mixing by
dry nitrogen flow under a positive nitrogen atmosphere. Enzymatic TG synthesis with evaporation by heating was not suitable
because of the increasing peroxide value of the oil.
Part of this article was presented at the annual meeting of the Japan Oil Chemists' Society at Sendai, Japan, October, 16,
1990. 相似文献
4.
Yoshihiro Hayashi Takuya Oishi Kaede Shirotori Yuki Marumo Atsushi Kosugi Shungo Kumada 《Drug development and industrial pharmacy》2018,44(7):1090-1098
Objectives: The aim of this study was to explore the potential of boosted tree (BT) to develop a correlation model between active pharmaceutical ingredient (API) characteristics and a tensile strength (TS) of tablets as critical quality attributes.Methods: First, we evaluated 81 kinds of API characteristics, such as particle size distribution, bulk density, tapped density, Hausner ratio, moisture content, elastic recovery, molecular weight, and partition coefficient. Next, we prepared tablets containing 50% API, 49% microcrystalline cellulose, and 1% magnesium stearate using direct compression at 6, 8, and 10?kN, and measured TS. Then, we applied BT to our dataset to develop a correlation model. Finally, the constructed BT model was validated using k-fold cross-validation.Results: Results showed that the BT model achieved high-performance statistics, whereas multiple regression analysis resulted in poor estimations. Sensitivity analysis of the BT model revealed that diameter of powder particles at the 10th percentile of the cumulative percentage size distribution was the most crucial factor for TS. In addition, the influences of moisture content, partition coefficients, and modal diameter were appreciably meaningful factors.Conclusions: This study demonstrates that BT model could provide comprehensive understanding of the latent structure underlying APIs and TS of tablets. 相似文献
5.
Seiichi Kawahara Nurul Hayati Yusof Kenshi Noguchi Kenichiro Kosugi Yoshimasa Yamamoto 《Polymer》2014
The outstanding mechanical properties of soft materials i.e. natural rubber are partly due to the organic–inorganic nanomatrix structure because numerous organic microparticles are dispersed in a small amount of an inorganic nanomatrix composed of inorganic nanoparticles and organic macromolecules. Here we form an organic–inorganic nanomatrix using graft-copolymerization of a vinyl monomer with an inorganic oxide precursor onto natural rubber particles with an average diameter of 1 μm dispersed in water. The inorganic oxide precursor is converted into inorganic oxide nanoparticles through hydrolysis and condensation, forming chemical linkages between natural rubber microparticles and inorganic oxide nanoparticles. Transmission electron microscopy indicates that the organic–inorganic nanomatrix is densely filled with inorganic oxide nanoparticles and the natural rubber microparticles are dispersed in the nanomatrix. This nanomatrix composite realizes both energetic elasticity and entropic elasticity of a soft material, opening a novel field of building block chemistry with respect to a pair of organic microparticles and inorganic nanoparticles. 相似文献
6.
The expression of mRNA encoding the inflammatory cytokines interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha(TNF-alpha) have been examined in radicular cysts by in situ hybridization. Furthermore, the biological activity of the contents of radicular cysts (RCC) has been assayed by adding extracts of RCC to cultured human gingival fibroblasts (HGFs) and analyzing the culture medium for the release of inflammatory cytokines. In the epithelial layer, keratinocytes expressed all cytokine mRNAs examined at various levels. Basal layer cells expressed mRNA for each cytokine. In the subepithelial granulation tissue of the cysts, fibroblasts and macrophages expressed mRNA for IL-6, IL-8, IL-1beta and TNF-alpha mRNA at varying levels; especially clear expression of TNF-alpha and IL-1beta mRNA was detected on macrophages. The infiltrating lymphoid cells, largely composed of T cells and plasma cells, expressed these cytokine mRNAs, especially those encoding IL-6 and IL-8, at various levels. In vitro analysis indicated dose-dependent release of both IL-6 and IL-8 by HGFs in response to RCC. After heating to 100 degrees C for 10 min, RCC almost completely failed to stimulate IL-6 release from HGFs. Furthermore, anti-IL-1beta antibody (neutralization test) did not prevent the stimulation of IL-6 release by RCC. Significant amounts of IL-6 and IL-8 were detected in RCC in two cases, and a trace amount of IL-1beta was detected in one case. This study demonstrated the wide expression of mRNA encoding inflammatory cytokines in radicular cyst tissues, and RCC itself was capable of stimulating IL-6 and IL-8 production from HGFs. 相似文献
7.
8.
Takahashi R Sato S Sodesawa T Nakamura N Tomiyama S Kosugi T Yoshida S 《Journal of nanoscience and nanotechnology》2001,1(2):169-176
A Ni/SiO2 catalyst was prepared by homogeneous precipitation of nickel hydroxide in a sol-gel-derived wet silica gel. The preparation process consists of two successive steps: gelation of silica in the presence of nickel nitrate and urea at 50 degrees C, followed by aging at higher temperature, typically at 80 degrees C, to decompose the urea. The decomposition of urea increases the pH of the solution in the wet gel, leading to the concurrence of structural rearrangement of silica gel and deposition of nickel species. As a result, the structure of the silica changes from a ramified polymeric network into particle aggregates that entrap the nickel cations in the particles. The resulting Ni/SiO2 contains large mesopores that have high thermal stability up to 1000 degrees C and highly dispersed Ni metal particles with typical crystallite size of 4 nm even at high Ni content at 20 wt%. 相似文献
9.
Low-altitude hyperspectral observation systems are promising sensing tools for acquisition of optical remote-sensing data under the humid subtropical climate in Japan. The system is also capable of acquiring leaf-scale optical information free from atmospheric effect. However, the leaf-scale hyperspectral data are affected by shading and various illumination conditions such that it is difficult to obtain consistent characteristics of the spectral information. The aim of this article is the extraction of Lambert coefficients as an inherent leaf spectral profile. In this work, we propose a dichromatic model-based principal component analysis on hyperspectral data by utilizing leaf-scale hyperspectral data in order to diminish the spectral difference caused by the illumination condition and bidirectional reflectance distribution function. The results show that indices of chlorophyll content based on the estimated Lambert coefficients are consistent with the growth stages of a paddy field, whether the illumination condition is clear sky or overcast. 相似文献
10.
We have calculated the transition rate for a string unpinning from a point barrier, using a truncated parabolic potential. In this approximation, it was shown that the result for this N-dimensional system has the one-dimensional form R=νeffexp (−ΔU/kTeff), where νeff is an effective frequency, ΔU the barrier height, Teff the effective temperature. There is a crossover temperature T* separating the high temperature classical behavior from the low temperature quantum rate and given by T*=ωeff/2k. The effective temperature is given by the actual temperature above T*, while below it, is given by the ground state energy, calculated using the effective frequency. The important point is that if one knows the transition rate at high T, then the crossover temperature and the low T transition rate may be calculated. The effective frequency has been calculated for dislocations in the classical regime: νeff0.26 (U0/Gb3) νD, where U0 is the binding energy with a pinning atom, G the shear modulus, b the Burgers vector, and νD is the Debye frequency. The predicted crossover temperature of a few tenths Kelvin for an Al crystal is in good agreement with our recent experimental results. 相似文献