A goal-striving life event and the onset of hypomanic and depressive episodes and symptoms: Perspective from the Behavioral Approach System (BAS) dysregulation theory.

On the basis of the behavioral approach system (BAS) dysregulation theory of bipolar disorder, this study examined the relation between occurrence of a BAS activation-relevant life event--goal striving--and onset of hypomanic and depressive episodes and symptoms. In particular, the authors examined the relation between preparing for and completing final exams (a goal-striving event) and onset of bipolar spectrum episodes and symptoms in college students with bipolar II disorder or cyclothymia (i.e., "soft" bipolar spectrum conditions). One hundred fifty-nine individuals with either a bipolar spectrum disorder (n=68) or no major affective psychopathology (controls; n=91) were further classified on the basis of whether they were college students (i.e., completed final exams). Consistent with the BAS dysregulation theory, preparing for and completing final exams was associated with an increase in hypomanic but not depressive episodes and symptoms in individuals with a soft bipolar spectrum diagnosis. Furthermore, self-reported BAS sensitivity moderated the presence of certain hypomanic symptoms during final exams. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Electronic `how things work' articles: two early prototypes

The electronic encyclopedia exploratorium (E³) is a vision of a future computer system-an electronic book describing how thing work. Typical articles in E³ will describe such mechanisms as compression refrigerators, engines, telescopes, and mechanical linkages. Each article will provide simulations, three-dimensional animated graphics that the user can manipulate, laboratory areas that allow a user to modify the device or experiment with related artifacts, and a facility for asking questions and receiving customized, computer-generated English-language explanations. Some of the foundational technology is discussed, focusing on topics in artificial intelligence, graphics, and user interfaces. The initial prototype system and the technical lessons learned from it, as well as the second prototype currently under construction, are described     

Control of contact in robots and biological systems

Summary form only given. The consequences of dynamic interaction caused by physical contact with objects is discussed. Robotic experience has demonstrated that contact with objects can result in unstable behavior, yet humans contact and manipulate objects with no evidence of contact instability. It is shown that impedance control may be used in a robot or prosthesis to eliminate contact instability. Evidence that a similar approach may be the basis of human motor behavior in comparable tasks is reviewed. A model based on exploitation of apparent neuromuscular impedance is shown to be remarkably competent to reproduce fine details of multi-joint reaching behavior. The implication of this model is that some of the stability properties associated with posture are preserved during movement and may be used to simplify its execution. Experiments in which human subjects held the handle of a manipulandum and performed simple reaching motions to visually presented targets are described     

Active transport of nitrofurantoin across the mammary epithelium in vivo

Nitrofurantoin is a commonly used urinary tract antibiotic that has been found at high concentrations in human milk. In vivo studies in rats were carried out to determine the mechanism by which this drug crosses the mammary epithelium. Lactating rats were gavage-fed with nitrofurantoin, and their milk and plasma levels of the antibiotic were measured at intervals up to 8 hr. The average milk-to-plasma (M/P) ratio, calculated from the areas under the milk and plasma curves, respectively, was 23 compared with a ratio predicted to be about 0.3 on the basis of lipid partitioning and protein binding determinations. M/P ratios for two nitrofurantoin congeners were also calculated. The neutral compound furazolidone had a M/P ratio of about 1, as predicted, whereas the basic compound furaltadone had a M/P ratio of 3.49 compared with a predicted ratio of 1.4. These data suggest that nitrofurantoin and, to a lesser extent, furaltadone are actively transported across the mammary epithelium into milk.     

The importance of choosing attractors for optimizing chaotic communications

In this brief, we consider methods to improve the performance of chaotic communication schemes. We study a system using a receiver which explicitly includes the presence of noise in the channel. We show how the choice of chaotic dynamical system generating the transmitted signal is crucial. We observe a large variation in bit error rate performance of the system as parameters in the maps are changed, and we propose a simple explanation for this variation.     

A piece wise linear suspension bridge model: nonlinear dynamics and orbit continuation

The effect of harmonic excitation on suspension bridges is examined as a first step towards the understanding of the effect of wind, and possibly certain kinds of earthquake, excitation on such structures. The Lazer-McKenna suspension bridge model is studied completely for the first time by using a methodology that has been successfully applied to models of rocking blocks and other free-standing rigid structures. An unexpectedly rich dynamical structure is revealed in this way. Conditions for the existence of asymptotic periodic responses are established, via a complicated nonlinear transcen- dental equation. A two-part Poincare map is derived to study the orbital stability of such solutions. Numerical results are presented which illustrate the application of the analytical procedure to find and classify stable and unstable solutions, as well as determine bifurcation points accurately. The richness of the possible dynamics is then illustrated by a menagerie of solutions which exhibit fold and flip bifurcations, period doubling, period adding, and sub- and superharmonic coexistence of solutions. The solutions are shown both in the phase plane and as Poincare map fixed points under parameter continuation using the package AUTO. Such results illustrate the possibility of the coexistence of 'dangerous', large-amplitude responses at the same point of parameter space as 'safe' solutions. The feasibility of experimental verification of the results is discussed.     

A fast analog mean-timer

A circuit is described that determines the average of the transit time of light from an event in a scintillation counter to the two ends of that counter. The design offers superior time resolution and a novel gating scheme that significantly reduces circuit dead-time.