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2005年内蒙古自治区将实现蒙西、蒙东电网联网。文中重点对内蒙古电网的安全稳定性和无功补偿现状进行分析,提出了应用动态无功补偿装置,提高电压稳定水平,改善电网供电质量的建议。 相似文献
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Wangxiao He Simeng Wang Jin Yan Yiping Qu Liang Jin Fang Sui Yujun Li Weiming You Guang Yang Qi Yang Meiju Ji Yongping Shao Peter X. Ma Wuyuan Lu Peng Hou 《Advanced functional materials》2019,29(10)
Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–protein interactions (PPIs), has been hampered by their inefficacious cellular internalization in diseased tissue. Therapeutic peptides engineered into nanostructures with stable spatial architectures and smart disease targeting ability may provide a viable strategy to overcome the pharmaceutical obstacles of peptides. This study describes a strategy to assemble therapeutic peptides into a stable peptide–Au nanohybrid, followed by further self‐assembling into higher‐order nanoclusters with responsiveness to tumor microenvironment. As a proof of concept, an anticancer peptide termed β‐catenin/Bcl9 inhibitors is copolymerized with gold ion and assembled into a cluster of nanohybrids (pCluster). Through a battery of in vitro and in vivo tests, it is demonstrated that pClusters potently inhibit tumor growth and metastasis in several animal models through the impairment of the Wnt/β‐catenin pathway, while maintaining a highly favorable biosafety profile. In addition, it is also found that pClusters synergize with the PD1/PD‐L1 checkpoint blockade immunotherapy. This new strategy of peptide delivery will likely have a broad impact on the development of peptide‐derived therapeutic nanomedicine and reinvigorate efforts to discover peptide drugs that target intracellular PPIs in a great variety of human diseases, including cancer. 相似文献
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为有效提高极地冰盖低温环境下温度测量的精度,设计了一款基于Pt1000的多点低温低功耗高精度铂电阻柔性温度链。温度链由主机和多个从机组成,主机用于读取整条温度链的数据并与外界进行数据交互,从机用于采集和上传温度数据,主机和从机之间采用RS485总线通讯方式。每个单点铂电阻温度测量单元都采用软件校正,单点测温误差不超过0.006 9℃。室内低温实验和现场试验表明,该温度链对低温环境下多点同时测温整体可靠性较高,适用于在极地环境下对冰川冰雪的温度场剖面检测。 相似文献
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