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1.
Zaidatul Akmal Othman Zaida Zakaria Joseph Bagi Suleiman Victor Udo Nna Aminah Che Romli Wan Syaheedah Wan Ghazali Mahaneem Mohamed 《International journal of molecular sciences》2021,22(8)
Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role. 相似文献
3.
Sangmin Lee Biao Che Meiling Tai Wanzhao Li Shin-Hyun Kim 《Advanced functional materials》2021,31(42):2105477
Hydrogel shells that compartmentalize the water core from the aqueous surrounding provide molecular selectivity on size and charge in transmembrane transport. It is highly demanding to produce thin hydrogel shells to minimize diffusion length and maximize core volume. Here, internal osmosis in water-in-oil-in-water-in-oil (W/O/W/O) triple-emulsion droplets is used to produce thin hydrogel shells enclosing a large water core. The triple-emulsion droplets are prepared to have an ultrathin middle oil layer using a capillary microfluidic device. The innermost water droplet has a higher osmolarity than the outer water layer containing photopolymerizable hydrogel precursors, which pumps water from the outer layer to the core through the ultrathin oil layer by the osmosis. Therefore, the outer layer gets thinner and hydrogel precursors are enriched while the size of the triple-emulsion droplets remains unchanged. Through photopolymerization of precursors and phase transfer from oil to water, hydrogel shells enclosing water core are produced in the water environment; the oil layer is ruptured for molecular exchange through the shells. The thickness and composition of the hydrogel shells are precisely controllable by the osmotic conditions. The shells show a high permeation rate due to the thinness as well as controlled cut-off threshold of permeation for neutral and charged molecules. 相似文献
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As a major pollutant source to urban receiving waters, the non-point source pollution from urban runoff needs to be well studied and effectively controlled. Based on monitoring data from urban runoff pollutant sources, this article describes a systematic estimation of total pollutant loads from the urban areas of Beijing. A numerical model was developed to quantify main pollutant loads of urban runoff in Beijing. A sub-procedure is involved in this method, in which the flush process influences both the quantity and quality of stormwater runoff. A statistics-based method was applied in computing the annual pollutant load as an output of the runoff. The proportions of pollutant from point-source and non-point sources were compared. This provides a scientific basis for proper environmental input assessment of urban stormwater pollution to receiving waters, improvement of infrastructure performance, implementation of urban stormwater management, and utilization of stormwater. 相似文献
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北京火车站抗震鉴定与加固技术 总被引:5,自引:3,他引:2
北京火车站抗震加固与改造设计项目组 《工程抗震与加固改造》2003,(1):25-29
北京火车站是首都重要的标志性建筑之一 ,195 9年建成 ,当时按 7度设防考虑 ,存在着许多不符合抗震要求的问题 ,一些设施也明显不能满足现代使用功能要求。北京火车站抗震加固与改造设计项目组 ,运用多种先进的加固手段 ,在保持原建筑外貌不变的前提下 ,实现了抗震能力和改善使用功能的协调 ,取得了大型公共建筑加固改造的新经验 相似文献
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用数值方法对泊松方程求解时,往往要对迭代的中间结果作适当的压缩处理,以加快收敛速度和避免溢出。本文提出一种单一指数因子的非线性压缩法。一维数值模拟结果表明,平衡态时不必进行压缩处理。而在非平衡态时,最佳指数压缩因子的大小与杂质浓度有关。参考本文给出的数值计算结果,根据给定器件的杂质浓度分布,选定一最佳指数压缩因子,可以使泊松方程的数值求解过程具有最快的收敛速度。 相似文献
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StudyonFactorsAffectingtheStructureofHighSpeedSteelIngotProducedbyESRLiZhengbang;CheXiangqianAbstract:Theinfluenceofthemetalp... 相似文献
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针对涠洲11-4油田W11-4D-A1井返吐油基泥浆堵塞油管问题,以渗透剂、乳化剂、分散剂、互溶剂为原料,制备了HYQ-965-Ⅲ解堵剂.考察了不同配方解堵剂中原料间的配伍性和溶垢效果,研究了最佳配方:渗透剂Ⅰ20%、乳化剂Ⅰ10%、分散剂10%、互溶剂10%、海水50%.将该解堵剂在W11-4D-A1井进行应用,从现场使用情况看,HYQ-965-Ⅲ对油基泥浆、原油具有很好的分散能力,成功解除了油管堵塞,达到预期设计要求. 相似文献